Variable | B Predicted change in the hazard for a unit increase in the predictor. | SE (B) | OR (95% CI) | P |
---|---|---|---|---|
pN | 0.670 | 0.127 | 1.954 (1.525-2.504) | 0.000 |
Lauren’s classification | 0.591 | 0.246 | 1.807 (1.116-2.925) | 0.016 |
Parameter | Number of patients (%) |
---|---|
Age (years ± standard deviation) (n = 108) | 66.12 ± 12.02 |
Gender (n = 105) | |
Male | 68 (63.0) |
Age (years ± standard deviation) (n = 66) | 65.07 ± 12.03 |
Female | 40 (37.0) |
Age (years ± standard deviation) (n = 39) | 67.90 ± 11.94 |
Lauren’s classification (n = 104) | |
Intestinal | 58 (55.8) |
Diffuse | 46 (44.2) |
Location (n = 101) | |
Upper | 40 (39.6) |
Lower | 34 (33.7) |
Mixed | 27 (26.7) |
Grade/differentiation (n = 105) | |
Well | 9 (8.6) |
Moderate | 24 (22.9) |
Poor | 72 (68.6) |
Vascular invasion (n = 80) | |
Present | 27 (33.8) |
Not present | 53 (66.3) |
Perineural invasion (n = 95) | |
Present | 44 (46.3) |
Not present | 51 (53.7) |
Lymphatic invasion (60) | |
Present | 53 (88.3) |
Not present | 7 (11.7) |
pN (n = 105) | |
0 | 24 (22.9) |
1-2 | 15 (14.3) |
3-6 | 20 (19.0) |
> 7 | 46 (43.8) |
pT (n = 105) | |
Muscularis propria | 6 (3.7) |
Subserosa | 50 (42.6) |
Serosa | 49 (36.1) |
Population | N | Genotype counts | P |
---|---|---|---|
EUR | 503 | 97 (C|C) / 246 (C|G) / 160 (G|G) | χ2 = 8.391; P = 0.015 a χ2 = 11.143; P = 0.004 b NS c |
SI (total)a | 283 | 80 (C|C) / 124 (C|G) / 79 (G|G) | |
SI (cases)b | 108 | 36 (C|C) / 48 (C|G) / 24 (G|G) | |
SI (controls)c | 175 | 44 (C|C) / 76 (C|G) / 55 (G|G) | |
EUR | 503 | 125 (C|C) / 259 (C|T) / 119 (T|T) | NS d NS e χ2 = 5.715; P = 0.057 f |
EUR - male | 240 | 56 (C|C) / 124 (C|T) / 60 (T|T) | _ c _ d χ2 = 6.348; P = 0.042 f |
SI (total)d | 280 | 80 (C|C) / 143 (C|T) / 57 (T|T) | |
SI (cases - female)e | 36 | 6 (C|C) / 23 (C|T) / 7 (T|T) | |
SI (cases - male)f | 65 | 25 (C|C) / 29 (C|T) / 11 (T|T) | |
EUR | 503 | 240 (A|A) / 217 (A|G) / 46 (G|G) | NS g F = 6.569; P = 0.034 h NS 1 |
EUR - female | 263 | 135 (A|A) / 109 (A|G) / 19 (G|G) | _ g F = 8.277; P = 0.014 h _ i |
SI (total)g | 279 | 136 (A|A) / 118 (A|G) / 25 (G|G) | |
SI (cases - female)h | 40 | 11 (A|A) / 25 (A|G) / 4 (G|G) | |
SI (cases - male)i | 68 | 36 (A|A) / 24 (A|G) / 8 (G|G) |
Parameter | Subject | Variant/Genotype | P | |||
---|---|---|---|---|---|---|
GG | CG | CC | ||||
Lauren’s classification | Intestinal | Total | 17 | 21 | 20 | |
Diffuse | 5 | 25 | 16 | |||
Intestinal | Male | 9 | 10 | 14 | ||
Diffuse | 5 | 20 | 8 | |||
Intestinal | Female | 8 | 11 | 6 | ||
Diffuse | 0 | 5 | 8 | |||
AA | AG | GG | ||||
Intestinal | Total | 18 | 33 | 7 | ||
Diffuse | 28 | 13 | 5 | χ2=9.951 | ||
Intestinal | Male | 15 | 14 | 4 | 0.472 F=1.836 | |
Diffuse | 20 | 9 | 4 | |||
Intestinal | Female | 3 | 19 | 3 | ||
Diffuse | 8 | 4 | 1 | |||
CC | CT | TT | ||||
Tumour differentiation | Well | Total | 1 | 4 | 4 | |
Moderate | 7 | 9 | 7 | |||
Poor | 23 | 39 | 7 | |||
Well | Male | 0 | 2 | 3 | ||
Moderate | 6 | 7 | 2 | 0.139 F=6.439 | ||
Poor | 19 | 20 | 6 | |||
Well | Female | 1 | 2 | 1 | ||
Moderate | 1 | 2 | 5 | |||
Poor | 19 | 20 | 6 | |||
AA | AG | GG | ||||
pT | Muscularispropria | Total | 1 | 4 | 1 | 0.232 F=5.250 |
Subserosa | 27 | 18 | 5 | |||
Serosa | 18 | 25 | 6 | |||
Muscularispropria | Male | 0 | 3 | 1 | ||
Subserosa | 22 | 6 | 2 | |||
Serosa | 13 | 14 | 5 | |||
Muscularispropria | Female | 1 | 1 | 0 | 0.816 F=1.967 | |
Subserosa | 5 | 12 | 3 | |||
Serosa | 5 | 11 | 1 | |||
AA | AG | GG | ||||
Tumour | Upper | Total | 14 | 23 | 3 | |
location | Lower | 13 | 15 | 6 | ||
Whole | 18 | 6 | 3 |
Genotype model | Cases (n)/Control group (n) | OR (95% CI) p value with Yates correction | P | PY |
---|---|---|---|---|
Dominant | 72/120 | 0.900 | χ2=0.149 | χ2=0.062 |
TT+CT vs. CC | vs. 32/48 | (0.527-1.536) | 0.699 | 0.803 |
Recessive | 18/36 | 0.797 | χ2=0.507 | χ2=0.309 |
TT vs. CT+CC | vs. 86/137 | (0.426-1.491) | 0.476 | 0.578 |
Heterozygous | 54/89 | 0.910 | χ2=0.108 | χ2=0.035 |
CT vs. CC | vs. 32/48 | (0.520-1.594) | 0.742 | 0.853 |
Dominant | 41/101 | 0.364 | χ2=9.848 | χ2=8.834 |
TT+CT vs. CC | vs. 26/26 | (0.192-0.691) | ||
Recessive | 11/26 | 0.763 | χ2=0.467 | χ2=0.241 |
TT vs. CT+CC | vs. 56/101 | (0.351-1.659) | 0.494 | 0.623 |
Heterozygous | 30/75 | 0.400 | χ2=6.959 | χ2=6.057 |
CT vs. CC | vs. 26/26 | (0.201-0.797) | ||
Dominant | 31/57 | 1.994 | χ2=1.862 | χ2=1.281 |
TT+CT vs. CC | vs. 6/22 | (0.731-5.437) | 0.172 | 0.258 |
Recessive | 7/13 | 1.185 | χ2=0.107 | χ2=0.004 |
TT vs. CT+CC | vs. 30/66 | (0.429-3.269) | 0.743 | 0.949 |
Heterozygous | 24/44 | 2.000 | χ2=1.775 | χ2=1.188 |
CT vs. CC | vs. 6/22 | (0.714-5.606) | 0.183 | 0.276 |
Dominant | 61/82 | 1.409 | χ2=1.927 | χ2=1.601 |
GG+AG vs. AA | vs. 47/89 | (0.868-2.287) | 0.165 | 0.206 |
Recessive | 12/13 | 1.519 | χ2=0.999 | χ2=0.615 |
GG vs. AA+AG | vs. 96/158 | (0.666-3.465) | 0.318 | 0.433 |
Heterozygous | 49/69 | 1.345 | χ2=1.304 | χ2=1.025 |
AG vs. AA | vs. 47/89 | (0.808-2.237) | 0.253 | 0.311 |
Dominant | 32/46 | 0.947 | χ2=0.029 | χ2=0.0002 |
GG+AG vs. AA | vs. 36/49 | (0.508-1.766) | 0.864 | 0.990 |
Recessive | 8/7 | 1.676 | χ2=0.917 | χ2=0.466 |
GG vs. AA+AG | vs. 60/88 | (0.577-4.868) | 0.338 | 0.495 |
Heterozygous | 24/39 | 0.838 | χ2=0.272 | χ2=0.124 |
AG vs. AA | vs. 36/49 | (0.430-1.630) | 0.602 | 0.725 |
Dominant | 29/36 | 2.929 | χ2=6.719 | χ2=5.737 |
GG+AG vs. AA | vs. 11/40 | (1.281-6.700) | ||
Recessive | 4/6 | 1.296 | χ2=0.147 | χ2=0.001 |
GG vs. AA+AG | vs. 36/70 | (0.344-4.889) | 0.701 | 0.971 |
Heterozygous | 25/30 | 3.030 | χ2=6.732 | χ2=5.709 |
AG vs. AA | vs. 11/40 | (1.292-7.108) |
Variants | Genotype | Cases (n) | Controls (n) | HWE (cases) | HWE (controls) | |
---|---|---|---|---|---|---|
GG | 24 | 55 | χ2=3,628 0.163 | χ2=1.08 0.299 | χ2=2.87 0.090 | |
CG | 48 | 76 | ||||
C/C | 36 | 44 | ||||
CC | 32 | 48 | χ2=1.059 0.589 | χ2=0.345 0.557 | χ2=0.035 0.852 | |
CT | 54 | 89 | ||||
TT | 18 | 39 | ||||
AA | 47 | 89 | χ2=2.291 0.318 | χ2=0.021 0.885 | χ2=0.005 0.941 | |
AG | 49 | 69 | ||||
GG | 12 | 13 | ||||
AA | 36 | 49 | χ2=1.186 0.553 | χ2=1.530 0.216 | χ2=0.040 0.841 | |
AG | 24 | 39 | ||||
GG | 8 | 7 | ||||
AA | 11 | 40 | F=6.955 | χ2=3.352 0.067 | χ2=0.013 0.909 | |
AG | 25 | 30 | ||||
GG | 4 | 6 |