CA19-9 serum levels predict micrometastases in patients with gastric cancer
, , , et | 23 avr. 2016
À propos de cet article
Article Category: Research Article
Publié en ligne: 23 avr. 2016
Pages: 204 - 211
Reçu: 04 oct. 2014
Accepté: 09 mai 2015
DOI: https://doi.org/10.1515/raon-2015-0025
Mots clés
© 2016 Radiol Oncol
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Median survival rates of patients with T1 to T4 N0 tumours according to their positive and negative Ca19-9 serum levels around the cut-off of 3.5 IU/ml
| T1N0 | Negative | 121 ± 15.7 |
| Positive | 126 ± 12.2 | |
| T2N0 | Negative | 121 ± 13.9 |
| Positive | 89 ± 13.1 | |
| T3N0 | Negative | 103 ± 18 |
| Positive | 65 ± 12.4 | |
| T4N0 | Negative | 47 ± 18.9 |
| Positive | 18 ± 2.2 |
Patient demographic and tumor characteristics according to their positive and negative Ca19-9 serum levels around the cut-off of 3.5 IU/ml
| Gender [male (%)] | 63 | 57 |
| Age (years ± SD) | 64 ± 12.2 | 64 ± 11.9 |
| ASA (%) | ||
| I | 41.8 | 37.1 |
| II | 37.3 | 37.1 |
| III | 20.9 | 25.7 |
| Lymphadenectomy (%) | ||
| D1 | 19.2 | 23.9 |
| D2 | 80.8 | 76.1 |
| Tumou r site (%) | ||
| Lesser curvature | 33.3 | 38.6 |
| Greater curvature | 38.9 | 40.4 |
| Anterior wall | 25.0 | 15.8 |
| Posterior wall | 1.4 | 2.6 |
| Circumferential | 1.4 | 2.6 |
| Differentiation (%) | ||
| Well | 27.4 | 21.0 |
| Moderate | 25.8 | 33.0 |
| Poor | 46.8 | 46.0 |
| Lauren (%) | ||
| Intestinal | 63.9 | 47.2 |
| Diffuse | 19.7 | 31.5 |
| Mixed | 16.4 | 21.3 |
| Lymphangial invasion [yes (%)] | 52.9 | 54.7 |
| Vascular invasion[yes (%)] | 7.3 | 11.1 |
| Perineural invasion[yes (%)] | 15.7 | 14.4 |
| T stage (%) | ||
| 1 | 31.5 | 43.8 |
| 2 | 38.4 | 28.9 |
| 3 | 26.0 | 18.4 |
| 4 | 4.1 | 8.8 |
| UICC (%) | ||
| Ia | 31.5 | 45.6 |
| Ib | 38.4 | 28.9 |
| IIa | 26.0 | 16.7 |
| IIb | 1.4 | 5.3 |
| IIIb | 2.7 | 3.5 |
| Tumour diameter (mm ± SD) | 52 ± 33.8 | 50 ± 32.4 |
| Number of extractedlymph nodes (n ± SD) | 21 ± 11.2 | 20 ± 10.7 |
Results of the multivariate regression model analysis
| Perineural invasion | 1.337 | 0.612 | 2.921 | NS |
| Tumour site | 1.151 | 0.881 | 1.502 | NS |
| T stage | 1.755 | 1.321 | 2.330 | < 0.0001 |
| Extracted lymph nodes | 0.972 | 0.948 | 0.997 | 0.026 |
| Preoperative Ca19-9 serum level | 1 | 1.000 | 1.001 | NS |
| Ca19-9 cut-off (3.5 IU/ml) | 1.045 | 0.528 | 2.068 | NS |