n | LRC (%) | DFS (%) | DSS (%) | OS (%) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5 yrs | 10 yrs | p | 5 yrs | 10 yrs | p | 5 yrs | 10 yrs | p | 5 yrs | 10 yrs | p | ||
All | 288 | 90 | 88 | - | 65 | 50 | - | 76 | 58 | 68 | 46 | - | |
Ruthenium | 127 | 78 | 75 | 71 | 60 | 92 | 79 | 87 | 68 | ||||
0.000 | 0.014 | 0.000 | 0.000 | ||||||||||
Enucleation | 161 | 100 | 100 | 60 | 42 | 64 | 42 | 54 | 31 | ||||
Men | 142 | 85 | 82 | 61 | 51 | 74 | 61 | 66 | 47 | ||||
0.026 | 0.673 | 0.647 | 0.952 | ||||||||||
Women | 146 | 95 | 93 | 69 | 49 | 78 | 55 | 70 | 46 | ||||
< 60 years | 150 | 89 | 86 | 74 | 58 | 86 | 68 | 84 | 64 | ||||
0.648 | 0.002 | 0.000 | 0.000 | ||||||||||
≥ 60 years | 138 | 90 | 90 | 56 | 40 | 65 | 47 | 52 | 28 |
Treatment | |||
---|---|---|---|
Brachytherapy | Enucleation | Total | |
130 | 161 | 291 | |
3 palliations | - | 3 | |
127 | 161 | 288 | |
Man | 58 | 84 | 142 |
Women | 69 | 77 | 146 |
Men | 58 (29-74) | 58 (19-86) | |
Women | 60 (22-89) | 61 (23-92) | |
1 | 38 | ||
2 | 69 | ||
3 | 8 | ||
No data | 12 | ||
< 3 mm | 11 | ||
3.1-5.0 mm | 64 | ||
5.1-7.2 mm | 49 | ||
> 7.8 mm | 3 | ||
No data | 0 | ||
≤ 10 mm | 52 | ||
10,1-12,0 mm | 38 | ||
> 12 mm | 25 | ||
No data | 12 | ||
161 | |||
Spindle cell | 33 | ||
Epithelioid | 38 | ||
Mixed | 23 | ||
No data | 37 |
lower | upper | |||||
---|---|---|---|---|---|---|
All patients | LRC | First treatment | 40.842 | 5.565 | 299.717 | 0.000 |
Gender | 2.658 | 1.245 | 5.678 | 0.012 | ||
DFS | First treatment | 1.628 | 1.144 | 2.316 | 0.007 | |
Age < 60 years vs. ≥ 60 years | 1.800 | 1.275 | 2.540 | 0.001 | ||
DSS | First treatment | 3.937 | 2.509 | 6.178 | 0.000 | |
Age < 60 years vs. ≥ 60 years | 2.534 | 1.714 | 3.747 | 0.000 | ||
OS | First treatment | 3.153 | 2.218 | 4.480 | 0.000 | |
Age < 60 years vs. ≥ 60 years | 3.818 | 2.710 | 5.377 | 0.000 | ||
Gender | 2.306 | 1.013 | 5.251 | 0.047 | ||
Ruthenium | LRC | |||||
Treatment time (≤ 96 h | 2.841 | 1.220 | 6.623 | 0.015 | ||
Treatment time (≤ 96 h vs. > 96 h) | 2.674 | 1.276 | 5.587 | 0.009 | ||
DFS | Base (< 11 mm | 2.519 | 1.015 | 6.250 | 0.046 | |
T-stage | 2.320 | 1.002 | 5.376 | 0.050 | ||
DSS | Age (< 60 years | 4.762 | 1.709 | 13.333 | 0.003 | |
OS | Base (< 11 mm | 3.610 | 1.391 | 9.434 | 0.008 | |
Age (< 60 years | 5.650 | 2.538 | 12.658 | 0.000 | ||
Nucleation | LRC | - | - | - | - | - |
DFS | Age (< 60 years | 2.132 | 1.149 | 3.968 | 0.016 | |
Histology S | 1.467 | 1.000 | 2.151 | 0.050 | ||
DSS | Age (< 60 years | 2.326 | 1.229 | 4.403 | 0.009 | |
Histology S | 1.555 | 1.052 | 2.298 | 0.027 | ||
OS | Age (< 60 years vs. ≥ 60 years) | 3.876 | 2.222 | 6.757 | 0.000 | |
Histology (S | 1.444 | 1.051 | 1.983 | 0.023 |
LRC (%) | DFS (%) | DSS (%) | OS (%) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | 5 yrs | 10 yrs | p | 5 yrs | 10 yrs | p | 5 yrs | 10 yrs | p | 5 yrs | 10 yrs | p | |
Men | 58 | 66 | 60 | 60 | 49 | 90 | 76 | 87 | 67 | ||||
0.003 | 0.039 | 0.703 | 0.859 | ||||||||||
Women | 69 | 89 | 87 | 81 | 69 | 93 | 81 | 88 | 70 | ||||
< 60 years | 68 | 76 | 71 | 76 | 66 | 98 | 89 | 98 | 83 | ||||
0.305 | 0.156 | 0.002 | 0.000 | ||||||||||
≥ 60 years | 59 | 80 | 80 | 65 | 51 | 84 | 65 | 75 | 52 | ||||
T-stage | |||||||||||||
1 | 38 | 79 | 79 | 73 | 67 | 97 | 84 | 94 | 71 | ||||
2 | 69 | 79 | 74 | 0.451 | 72 | 57 | 0.354 | 90 | 75 | 0.378 | 86 | 72 | 0.508 |
3 | 8 | 60 | 40 | 45 | 45 | 86 | 86 | 0 | 50 | ||||
Tumour thickness | |||||||||||||
2-5.9 mm | 97 | 83 | 82 | 0.003 | 74 | 66 | 0.021 | 92 | 79 | 0.489 | 86 | 68 | 0.724 |
6-.2 mm | 29 | 64 | 54 | 64 | 39 | 96 | 80 | 96 | 70 | ||||
Base | |||||||||||||
< 11 mm | 61 | 83 | 83 | 0.043 | 80 | 0.002 | 96 | 84 | 0.024 | 96 | 77 | 0.002 | |
≥ 11 mm | 54 | 70 | 64 | 60 | 45 | 87 | 72 | 78 | 64 | ||||
Dose rate Top (Gy/h) | |||||||||||||
≥ 108 Gy | 53 | 81 | 78 | 0.302 | 74 | 66 | 0.099 | 95 | 84 | 0.280 | 87 | 72 | 0.690 |
< 108 Gy | 52 | 74 | 68 | 68 | 46 | 89 | 72 | 87 | 62 | ||||
Dose- rate base (Gy/h) | |||||||||||||
≥ 532 | 53 | 82 | 74 | 0.708 | 74 | 57 | 0.804 | 95 | 81 | 0.665 | 87 | 69 | 0.862 |
< 532 | 52 | 74 | 71 | 68 | 55 | 89 | 75 | 87 | 65 | ||||
Treatment time | |||||||||||||
≤ 96 hours | 52 | 87 | 84 | 0.015 | 80 | 72 | 0.004 | 95 | 84 | 0.400 | 89 | 74 | 0.565 |
> 96 hours | 53 | 68 | 62 | 62 | 40 | 89 | 71 | 85 | 60 |
DFS (%) | DSS (%) | OS (%) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
n | 5 yrs | 10 yrs | p | 5y | 10 yrs | p | 5 yrs | 10 yrs | p | |
Men | 84 | 62 | 51 | 0.154 | 63 | 51 | 53 | 34 | 0.775 | |
Women | 77 | 59 | 33 | 65 | 34 | 0,275 | 56 | 27 | ||
< 60 years | 82 | 73 | 52 | 0.001 | 76 | 52 | 74 | 51 | 0.000 | |
≥ 60 years | 79 | 49 | 30 | 50 | 30 | 0.000 | 34 | 10 | ||
Spindle cell | 33 | 74 | 70 | 81 | 72 | 66 | 49 | |||
epithelioid | 38 | 56 | 36 | 0.050 | 61 | 33 | 0.029 | 55 | 24 | 0.026 |
Mixed cell | 23 | 62 | 28 | 67 | 24 | 52 | 15 |