<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1*07 (OR 3.52; p = 0.001), HLA-DRB1*15 (OR 3.02; p = 0.001) and HLA-DRB1 *17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles -DRB1*11(OR 0.37; p = 0.005) and -DRB1*13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.</p></abstract>

In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1*07 (OR 3.52; p = 0.001), HLA-DRB1*15 (OR 3.02; p = 0.001) and HLA-DRB1 *17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles -DRB1*11(OR 0.37; p = 0.005) and -DRB1*13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.

Immunogenetic Manifestations of Lyme Borreliosis / Imūnìenģtiskās Izpausmes Laimboreliozes Gadījumā

Institute of Food Safety, Animal Health and Environment, Lejupes iela 3, Rīga, LV-1076, LATVIA

Laboratory of Clinical Immunology and Immunogenetics, Rīga Stradiņš University, Kronvalda iela 9, Rīga, LATVIA

Department of Infectology and Dermatology, Rīga Stradiņš University, Infectology Centre of Latvia, Linezera iela 3, Rīga, LATVIA

Centre for Disease Prevention and Control, Duntes iela 22, Rīga, LV-1005, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case...

Immunogenetic Manifestations of Lyme Borreliosis / Imūnìenģtiskās Izpausmes Laimboreliozes Gadījumā

Publié en ligne: 04 août 2016

Pages: 215 - 219

Reçu: 19 déc. 2015

DOI: https://doi.org/10.1515/prolas-2016-0034

Mots clés
Lyme borreliosis, HLA alleles, PCR-SSP

© by Lilija Kovaļčuka

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Immunogenetic Manifestations of Lyme Borreliosis / Imūnìenģtiskās Izpausmes Laimboreliozes Gadījumā

Publié en ligne: 04 août 2016

Pages: 215 - 219

Reçu: 19 déc. 2015

DOI: https://doi.org/10.1515/prolas-2016-0034

Mots clésLyme borreliosis, HLA alleles, PCR-SSP

© by Lilija Kovaļčuka

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
Lyme borreliosis, HLA alleles, PCR-SSP