<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The Fricke xylenol orange (FX) gel system is a chemical dosimeter characterized by good sensitivity, linear dose response, tissue equivalence, no toxicity, easy preparation, reproducibility and low cost. Thanks to the presence of the gelatinous matrix, the system is particularly suitable to perform reliable 3D mapping of the absorbed dose spatial distribution via magnetic resonance imaging (MRI) or optical techniques. The aim of this work is to study in a systematic way the influence of the pre-irradiation storage procedure upon sensitivity, dose response stability and lifetime of use of a FX gel system made with gelatin from porcine skin subjected to homogeneous irradiation. For this purpose, different pre-irradiation storage procedures, in terms of temperature and duration of each storage step, were investigated. In order to evaluate the dose response stability, the optical analyses of the samples were performed up to 6 hours after irradiation. Moreover, the samples were irradiated at time intervals of 24 hours for up to 7 days after preparation in order to evaluate the system lifetime of use. Regardless of their thermal and temporal life, the samples show linear dose responses in the investigated dose range (3-24 Gy) and an increase of sensitivity with the time elapsed between preparation and irradiation. Among the three pre-irradiation storage procedures considered here, a procedure that provides the best dose response stability and lifetime of use was identified and recommended for further use. The analyzed dosimetric system possesses good properties that make it promising for medical application, particularly concerning the evaluation of pre-treatment plan quality assurance within the conformational external beam radiotherapy</p></abstract>

The Fricke xylenol orange (FX) gel system is a chemical dosimeter characterized by good sensitivity, linear dose response, tissue equivalence, no toxicity, easy preparation, reproducibility and low cost. Thanks to the presence of the gelatinous matrix, the system is particularly suitable to perform reliable 3D mapping of the absorbed dose spatial distribution via magnetic resonance imaging (MRI) or optical techniques. The aim of this work is to study in a systematic way the influence of the pre-irradiation storage procedure upon sensitivity, dose response stability and lifetime of use of a FX gel system made with gelatin from porcine skin subjected to homogeneous irradiation. For this purpose, different pre-irradiation storage procedures, in terms of temperature and duration of each storage step, were investigated. In order to evaluate the dose response stability, the optical analyses of the samples were performed up to 6 hours after irradiation. Moreover, the samples were irradiated at time intervals of 24 hours for up to 7 days after preparation in order to evaluate the system lifetime of use. Regardless of their thermal and temporal life, the samples show linear dose responses in the investigated dose range (3-24 Gy) and an increase of sensitivity with the time elapsed between preparation and irradiation. Among the three pre-irradiation storage procedures considered here, a procedure that provides the best dose response stability and lifetime of use was identified and recommended for further use. The analyzed dosimetric system possesses good properties that make it promising for medical application, particularly concerning the evaluation of pre-treatment plan quality assurance within the conformational external beam radiotherapy

Effects of the pre-irradiation storage procedure on the dose response of a Fricke xylenol orange gel dosimeter

Department of Energy, Nuclear Engineering Division-CeSNEF, Politecnico di Milano, Piazza L. da Vinci 32, Milano, I-20133, Italy, Tel.: 02239 9635

Medical Physics Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori, via Venezian, Milano, I-20113, Italy

Department of Physics, Università degli Studi di Milano and INFN, via Celoria 16, Milano, I-20133 Italy

Nukleonika

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Fricke xylenol orange (FX) gel system is a chemical dosimeter characterized by good sensitivity, linear dose response, tissue equivalence, no toxicity,...

Effects of the pre-irradiation storage procedure on the dose response of a Fricke xylenol orange gel dosimeter

Publié en ligne: 25 sept. 2015

Pages: 603 - 607

Reçu: 24 sept. 2014

Accepté: 20 mai 2015

DOI: https://doi.org/10.1515/nuka-2015-0099

Mots clés
radiation dosimetry · Fricke-gelatin-xylenol orange dosimeter · optical absorbance measurement

© by Giulia Maria Liosi

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of the pre-irradiation storage procedure on the dose response of a Fricke xylenol orange gel dosimeter

Publié en ligne: 25 sept. 2015

Pages: 603 - 607

Reçu: 24 sept. 2014

Accepté: 20 mai 2015

DOI: https://doi.org/10.1515/nuka-2015-0099

Mots clésradiation dosimetry · Fricke-gelatin-xylenol orange dosimeter · optical absorbance measurement

© by Giulia Maria Liosi

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
radiation dosimetry · Fricke-gelatin-xylenol orange dosimeter · optical absorbance measurement