<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Gnathostomiasis is a prevalent zoonosis in humans in some regions of the world. The genus <italic>Gnathostoma</italic> is considered an accidental parasite for humans; <italic>G. binucleatum</italic> is the endemic species in Nayarit, Mexico. This work was designed to determine the proteolytic activity of the excretory-secretory products (ESP) of advanced third-stage larvae (ADVL3) of <italic>Gnathostoma binucleatum</italic> against human fibronectin and antibodies from human and sheep. Our findings showed protease activity against human fibronectin as well as sheep and human gamma globulins of the ESP at molecular weights of 80 and 56 kDa. The proteases found in the ESP of <italic>G. binucleatum</italic> are thus candidate molecules for consideration as pathogenic elements, owing to the fact that they destroy proteins of the host tissue, which probably allows them to migrate through those tissues and degrade molecules involved in the humoral immune response.</p></abstract>

Gnathostomiasis is a prevalent zoonosis in humans in some regions of the world. The genus Gnathostoma is considered an accidental parasite for humans; G. binucleatum is the endemic species in Nayarit, Mexico. This work was designed to determine the proteolytic activity of the excretory-secretory products (ESP) of advanced third-stage larvae (ADVL3) of Gnathostoma binucleatum against human fibronectin and antibodies from human and sheep. Our findings showed protease activity against human fibronectin as well as sheep and human gamma globulins of the ESP at molecular weights of 80 and 56 kDa. The proteases found in the ESP of G. binucleatum are thus candidate molecules for consideration as pathogenic elements, owing to the fact that they destroy proteins of the host tissue, which probably allows them to migrate through those tissues and degrade molecules involved in the humoral immune response.

Proteases secreted by <italic>Gnathostoma binucleatum</italic> degrade fibronectin and antibodies from mammals

Universidad Autónoma de Nayarit, Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, Cd. de la Cultura, Amado Nervo s/n, Edificio CEMIC 05, CP 63190, Tepic, Nayarit, México

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Proteases secreted by  degrade fibronectin and antibodies from mammals

Gnathostomiasis is a prevalent zoonosis in humans in some regions of the world. The genus Gnathostoma is considered an accidental parasite for humans; G....

Proteases secreted by Gnathostoma binucleatum degrade fibronectin and antibodies from mammals

Publié en ligne: 02 févr. 2015

Pages: 6 - 10

Reçu: 24 avr. 2014

Accepté: 10 oct. 2014

DOI: https://doi.org/10.1515/helmin-2015-0005

Mots clés
proteases, mammal proteins, excretory-secretory products

© 2015 Institute of Parasitology, SAS, Košice

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Proteases secreted by Gnathostoma binucleatum degrade fibronectin and antibodies from mammals

Publié en ligne: 02 févr. 2015

Pages: 6 - 10

Reçu: 24 avr. 2014

Accepté: 10 oct. 2014

DOI: https://doi.org/10.1515/helmin-2015-0005

Mots clésproteases, mammal proteins, excretory-secretory products

© 2015 Institute of Parasitology, SAS, Košice

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
proteases, mammal proteins, excretory-secretory products