<abstract xmlns="http://www.w3.org/1999/xhtml"><p>For comparative purposes, a quantitative estimation of antioxidant activity of phenolic compounds of different classes was conducted by way of the polarography method, via the ADP-Fe<sup>2+</sup> model of the induced ascorbate-dependent lipid peroxidation of rat liver micro-somes within an <italic>in-vitro</italic> system. As a result, it was recognized that the antioxidant properties of phenolic compounds depend on the nature and chemical structure of several substances. In respect of such activity, leaders in the classes of investigated polyphenolic compounds are: Propyl gallate = Gallotannin (Phenolcarboxylic acids and their derivatives) > Quercetin = Myricetin (Flavonols) > Luteolin (Flavo n) = Mangiferin (Xanthones) > Kaempferol (Flavonols) = Catechin (Flavans). Thus, the assessment of the inhibition ability of the lipid peroxidation of microsomes by phenolic compounds can be used as an accessible test for the preliminary quantitative estimation of their antioxidant properties.</p></abstract>

For comparative purposes, a quantitative estimation of antioxidant activity of phenolic compounds of different classes was conducted by way of the polarography method, via the ADP-Fe2+ model of the induced ascorbate-dependent lipid peroxidation of rat liver micro-somes within an in-vitro system. As a result, it was recognized that the antioxidant properties of phenolic compounds depend on the nature and chemical structure of several substances. In respect of such activity, leaders in the classes of investigated polyphenolic compounds are: Propyl gallate = Gallotannin (Phenolcarboxylic acids and their derivatives) > Quercetin = Myricetin (Flavonols) > Luteolin (Flavo n) = Mangiferin (Xanthones) > Kaempferol (Flavonols) = Catechin (Flavans). Thus, the assessment of the inhibition ability of the lipid peroxidation of microsomes by phenolic compounds can be used as an accessible test for the preliminary quantitative estimation of their antioxidant properties.

A comparative study of phenolic compound antioxidant activity by the polarography method, using microsomal lipid peroxidation <italic>in vitro</italic>

Department of Pharmacology and Toxicology

Department of Physical and Colloidal Chemstry

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A comparative study of phenolic compound antioxidant activity by the polarography method, using microsomal lipid peroxidation 

For comparative purposes, a quantitative estimation of antioxidant activity of phenolic compounds of different classes was conducted by way of the polarography...

A comparative study of phenolic compound antioxidant activity by the polarography method, using microsomal lipid peroxidation in vitro

Publié en ligne: 03 janv. 2019

Pages: 186 - 189

Reçu: 20 févr. 2018

Accepté: 06 juil. 2018

DOI: https://doi.org/10.1515/cipms-2018-0034

Mots clés
lipid peroxidation of microsomes, antioxidant activity, phenolic compounds, polarography method

© 2018 Anatolii Gordiienko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A comparative study of phenolic compound antioxidant activity by the polarography method, using microsomal lipid peroxidation in vitro

Publié en ligne: 03 janv. 2019

Pages: 186 - 189

Reçu: 20 févr. 2018

Accepté: 06 juil. 2018

DOI: https://doi.org/10.1515/cipms-2018-0034

Mots cléslipid peroxidation of microsomes, antioxidant activity, phenolic compounds, polarography method

© 2018 Anatolii Gordiienko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
lipid peroxidation of microsomes, antioxidant activity, phenolic compounds, polarography method