<abstract xmlns="http://www.w3.org/1999/xhtml"><p> TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This pilot study was performed on 48 patients. Initial studies indicate a high frequency of methylation in HPV-associated (57.1%) and EBV - associated OSCC (60%) cases, whilst the highest exists in co-infection HPV/EBV (75%). Future studies on a larger group of patients, of the mechanisms of co-infection and their role in oral squamous cell carcinoma, are necessary.</p></abstract>

TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This pilot study was performed on 48 patients. Initial studies indicate a high frequency of methylation in HPV-associated (57.1%) and EBV - associated OSCC (60%) cases, whilst the highest exists in co-infection HPV/EBV (75%). Future studies on a larger group of patients, of the mechanisms of co-infection and their role in oral squamous cell carcinoma, are necessary.

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This...

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Publié en ligne: 29 déc. 2017

Pages: 119 - 122

Reçu: 26 juin 2017

Accepté: 29 juil. 2017

DOI: https://doi.org/10.1515/cipms-2017-0021

Mots clés
TP53, methylation, OSCC, EBV, HPV

© 2018

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Publié en ligne: 29 déc. 2017

Pages: 119 - 122

Reçu: 26 juin 2017

Accepté: 29 juil. 2017

DOI: https://doi.org/10.1515/cipms-2017-0021

Mots clésTP53, methylation, OSCC, EBV, HPV

© 2018

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
TP53, methylation, OSCC, EBV, HPV