Autophagy in the pancreatic islets after the administration of cladribine in accordance to two different modes of therapy

1. Aghajan M., Li N., Karin M.: Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol., 27, 10, 2012. doi: 10.1111/j.1440-1746.2011.07008.x.Search in Google Scholar

2. Agostini S. et al.: A new dual-promotor system for cardiomyocyte - specific conditional induction of apoptosis. Biomed Res Int., 13, 2013, doi:10.1155/2013/845816.Search in Google Scholar

3. Barth S., Glick D., Macleod K.F.: Autophagy: assays and artifacts. J. Pathol., 221, 117, 2010.Search in Google Scholar

4. Bergamini E. et al.: The anti-aging effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically. Biomed Pharmacother., 57, 203, 2003.10.1016/S0753-3322(03)00048-9Open DOISearch in Google Scholar

5. Burgoyne L.A.: The Mechanisms of Pyknosis: Hypercondensation and Death. Experimental Cell Research, 248, 214, 1999.10.1006/excr.1999.440610094828Search in Google Scholar

6. Cardoen S. et al.: Effects of 2-Chloro-2’-Deoxyadenosine on the Cell Cycle in the Human Leukemia EHEB Cell Line. Nucleosides, Nucleotides & Nucleic Acids, 23, 1425, 2004.10.1081/NCN-20002765315571271Search in Google Scholar

7. Chilmonczyk Z.: Receptory śmierci - cel molekularny leków przeciwnowotworowych. Gazeta Farmaceutyczna, 1, 34, 2009.Search in Google Scholar

8. Chylińska-Wrzos P. et al.: Expression of p53 protein and the histomorphological view of epidermis in experimental animals after cladribine application. IJVR, 15, 198, 2014.Search in Google Scholar

9. Chylińska-Wrzos P. et al.: The intrinsic or the extrinsic pathways of apoptosis in the epidermis after cladribine application? Journal of Biomedical Science and Engineering, 6/3, 265, 2013.10.4236/jbise.2013.63033Open DOISearch in Google Scholar

10. Deretic V.: Autophagy in innate and adaptive immunity. Trends Immunol., 2, 523, 2005.10.1016/j.it.2005.08.00316099218Search in Google Scholar

11. Deretic V., Saitoh T., Akira S.: Autophagy in infection, inflammation and immunity. Nat Rev Immunol., 13, 10, 722, 2013.Search in Google Scholar

12. Fischer U., Schulze-Osthoff K.: New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev., 57, 187, 2005.10.1124/pr.57.2.615914467Open DOISearch in Google Scholar

13. Fortunato F. et al.: Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis. Gastroenterology, 137, 350, 2009.10.1053/j.gastro.2009.04.00319362087Search in Google Scholar

14. Fujii S. et al.: Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci., 99, 1813, 2008.10.1111/j.1349-7006.2008.00893.x18616529Search in Google Scholar

15. Glick D., Barth S., Macleod K.F.: Autophagy: cellular and molecular mechanisms. J. Pathol., 221, 3, 2010.Search in Google Scholar

16. Hashimoto D. et al.: Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs. Eur J Cancer, 50, 1382, 2014.10.1016/j.ejca.2014.01.01124503026Search in Google Scholar

17. Jasinski L. et al.: A comparison of caspase 3 expression in the endocrine and exocrine parts of the pancreas after cladribine application according to the “leukemic” schema. Curr Issues Pharm Med Sci., 30, 9, 2017.10.1515/cipms-2017-0002Search in Google Scholar

18. Jędrych M. et al.: Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovarian surface epithelial cells of cladribine-treated rats. Protoplasma, 250, 1025, 2013.10.1007/s00709-012-0461-z378817723344798Search in Google Scholar

19. Klionsky D.J. et al.: Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryo. Autophagy, 4, 151, 2008.10.4161/auto.5338265425918188003Open DOISearch in Google Scholar

20. Leist T.P., Weissert R.: Cladribine: Mode of Action and Implications for Treatment of Multiple Sclerosis. Clin Neuropharm., 34, 28, 2011.Search in Google Scholar

21. Mukubou H. et al.: The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. Int J Oncol., 37, 821, 2010.10.3892/ijo_0000073220811703Search in Google Scholar

22. Ozaki N. et al.: Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling. Biochem Biophys Res Commun., 446, 224, 2014.10.1016/j.bbrc.2014.02.11124607897Search in Google Scholar

23. Pardo R. et al.: Gemcitabine induces the VMP-1 mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells. Pancreatology, 10, 19, 2010.10.1159/00026468020299819Search in Google Scholar

24. Petrie A., Sabin C. editors (2006). Statystyka medyczna w zarysie. Warszawa, PZWL.Search in Google Scholar

25. Ricci M., Zong W.: Chemotherapeutic approaches for targeting cell death pathways. Oncologist, 11, 342, 2006.10.1634/theoncologist.11-4-342313247116614230Open DOISearch in Google Scholar

26. Rivera J. et al.: Autophagy defends pancreatic beta cells from human islet amyloid polypepetide - induced toxity. J. Clin Invest., 124, 8, 3489-500, 1981, doi: 10.1172/JCI71981.Search in Google Scholar

27. Ropolo A. et al.: Chemotherapy and autophagy-mediated cell death in pancreatic cancer cells. Pancreatology, 12, 1, 2012.10.1016/j.pan.2011.11.00322487466Search in Google Scholar

28. Rosenfeldt M. et al.: p53 status determines the role of autophagy in pancreatic tumour development. Nature, 12, 504, 296, 2013.10.1038/nature1286524305049Search in Google Scholar

29. Sau W.H., Mody H.R., Rajgopal G.: Overcoming nucleoside analog chemoresistance of pancreatic cancer: A therapeutic challenge. Cancer Letters, 320, 138, 2012.Search in Google Scholar

30. Shuang W. et al.: Pancreatic islet cell autophagy during aging in rats. Clin Invest Med., 36, 2, E72-E80, 2013.10.25011/cim.v36i2.1956923544608Search in Google Scholar

31. Smolewski P., Darzynkiewicz Z.: Współczesne metody badania apoptozy. Acta Haematologica Polonica, 34, 35, 2003.Search in Google Scholar

32. Stachura J. (2003). Uszkodzenie i śmierć komórki. In: Patologia znaczy słowo o chorobie, vol I - patologia ogólna. Stachura J., Domagała W. (editors). PAU, Kraków, PUK; p. 12-13.Search in Google Scholar

33. Stanisz A. editor (2005). Biostatystyka. Podręcznik dla studentów ilekarzy. Kraków, WUJ. Search in Google Scholar

34. Vernon P.J., Tang D.: Eat-me: autophagy, phagocytosis, and reactive oxygen species signaling. Antioxid. Redox Signaling, 18, 677, 2013.10.1089/ars.2012.4810363209422871044Search in Google Scholar

35. Wawryk-Gawda E. et al.: Use of selected purine analogs in neoplastic and autoimmune diseases. Annales Universitatis Mariae Curie- Skłodowska, Sectio DDD: Pharmacia, 24/4, 29, 2011.Search in Google Scholar

36. Wawryk-Gawda E. et al.: Intrinsic apoptosis pathway in fallopian tube epithelial cells induced by cladribine. Scientific World Journal, 2, 928036, 2014, doi: 10.1155/2014/928036.Search in Google Scholar

37. Wawryk-Gawda E. et al.: P53 protein in proliferation, repair and apoptosis of cells. Protoplasma, 251, 525, 2014.10.1007/s00709-013-0548-1399783024043441Search in Google Scholar

38. Yang A. et al.: Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov., 4, 905, 2014.10.1158/2159-8290.CD-14-0362412549724875860Search in Google Scholar

39. Yang S. et al.: Pancreatic cancers require autophagy for tumor growth. Genes Dev., 25, 717, 2011.10.1101/gad.2016111307093421406549Search in Google Scholar

40. Zulian G.B. (1994). A review of fludarabine and cladribine in solid tumors. In: Innovate Antimetabolites’ in Solid Tumors. Aapro M.S. (editor). Berlin, Springer Verlag; p. 29-3.Search in Google Scholar