<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Nitric oxide (NO) is a relatively novel messenger that plays a significant role in a wide range of physiological processes. Currently, it is known that, both, lack and excess of NO can cause diseases, thus a lot of substances have been discovered and utilized which can change the concentration of this molecule within the organism. The aim of the present work is to provide an overview of currently used agents modulating the L-arginine:NO:cGMP pathway, as well as to summarize current understanding of their pharmacological profiles. Nowadays, most of these agents are employed particularly in the treatment of cardiovascular diseases. Further studies can hold promise for enhancing the therapeutic equipment for a variety of other impairments, such as osteoporosis, and also in treatments of the central nervous system.</p></abstract>

Nitric oxide (NO) is a relatively novel messenger that plays a significant role in a wide range of physiological processes. Currently, it is known that, both, lack and excess of NO can cause diseases, thus a lot of substances have been discovered and utilized which can change the concentration of this molecule within the organism. The aim of the present work is to provide an overview of currently used agents modulating the L-arginine:NO:cGMP pathway, as well as to summarize current understanding of their pharmacological profiles. Nowadays, most of these agents are employed particularly in the treatment of cardiovascular diseases. Further studies can hold promise for enhancing the therapeutic equipment for a variety of other impairments, such as osteoporosis, and also in treatments of the central nervous system.

Drugs modulating the L-arginine:NO:cGMP pathway – current use in therapy

Student Research Group at the Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4A, 20-093 Lublin, Poland

Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4A, 20-093 Lublin, Poland

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Drugs modulating the L-arginine:NO:cGMP pathway \u2013 current use in therapy"}

Nitric oxide (NO) is a relatively novel messenger that plays a significant role in a wide range of physiological processes. Currently, it is known that, both,...

Drugs modulating the L-arginine:NO:cGMP pathway – current use in therapy

Publié en ligne: 06 mai 2016

Pages: 14 - 20

Reçu: 13 nov. 2015

Accepté: 26 nov. 2015

DOI: https://doi.org/10.1515/cipms-2016-0004

Mots clés
nitric oxide, vasodilators, nebivolol, sildenafil, statins, L-arginine

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Drugs modulating the L-arginine:NO:cGMP pathway – current use in therapy

Publié en ligne: 06 mai 2016

Pages: 14 - 20

Reçu: 13 nov. 2015

Accepté: 26 nov. 2015

DOI: https://doi.org/10.1515/cipms-2016-0004

Mots clésnitric oxide, vasodilators, nebivolol, sildenafil, statins, L-arginine

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
nitric oxide, vasodilators, nebivolol, sildenafil, statins, L-arginine