<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Fosfomycin is an old antibiotic with a unique chemical structure and with broadspectrum activity against numerous bacterial pathogens, both Gram-positive and Gramnegative, including resistant and multi-resistant strains. This antibiotic was accepted into clinical practice in the early 1970s. Its use, however, has been limited for several years for treating mainly lower uncomplicated urinary tract infections (in the form of fosfomycin trometamol taken orally). Nowadays, many clinicians and scientists are looking at this antibacterial drug for its employment in the treatment of severe infections caused by multi-resistant bacteria. Fosfomycin as an intravenous formulation (fosfomycin disodium) achieves clinically relevant concentrations in the serum and the cerebrospinal fluid, in kidney, bladder wall, prostate, lungs, bone and heart valves tissues, as well as in inflamed tissues and abscess fluid. The available clinical studies confirmed the efficacy of intravenous fosfomycin for the management of severe infections caused by multiresistant pathogens.</p></abstract>

Fosfomycin is an old antibiotic with a unique chemical structure and with broadspectrum activity against numerous bacterial pathogens, both Gram-positive and Gramnegative, including resistant and multi-resistant strains. This antibiotic was accepted into clinical practice in the early 1970s. Its use, however, has been limited for several years for treating mainly lower uncomplicated urinary tract infections (in the form of fosfomycin trometamol taken orally). Nowadays, many clinicians and scientists are looking at this antibacterial drug for its employment in the treatment of severe infections caused by multi-resistant bacteria. Fosfomycin as an intravenous formulation (fosfomycin disodium) achieves clinically relevant concentrations in the serum and the cerebrospinal fluid, in kidney, bladder wall, prostate, lungs, bone and heart valves tissues, as well as in inflamed tissues and abscess fluid. The available clinical studies confirmed the efficacy of intravenous fosfomycin for the management of severe infections caused by multiresistant pathogens.

Overview on fosfomycin and its current and future clinical significance

Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Medical University of Lublin, Poland

Public District Hospital in Krasnystaw, Poland

Chair and Clinic Infection Diseases, Independent Public Teaching Hospital No 1 in Lublin, Poland

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Overview on fosfomycin and its current and future clinical significance"}

Fosfomycin is an old antibiotic with a unique chemical structure and with broadspectrum activity against numerous bacterial pathogens, both Gram-positive and...

Overview on fosfomycin and its current and future clinical significance

Publié en ligne: 09 mai 2015

Pages: 33 - 36

Reçu: 02 mars 2015

Accepté: 18 mars 2015

DOI: https://doi.org/10.1515/cipms-2015-0039

Mots clés
fosfomycin, urinary tract infections, multi-resistant bacterial infections

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Overview on fosfomycin and its current and future clinical significance

Publié en ligne: 09 mai 2015

Pages: 33 - 36

Reçu: 02 mars 2015

Accepté: 18 mars 2015

DOI: https://doi.org/10.1515/cipms-2015-0039

Mots clésfosfomycin, urinary tract infections, multi-resistant bacterial infections

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
fosfomycin, urinary tract infections, multi-resistant bacterial infections