<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this work is to study the effects of eccentric hypertrophy on the electromechanics of a single myocardial ventricular fiber by means of a one-dimensional finite-element strongly-coupled model. The electrical current ow model is written in the reference configuration and it is characterized by two geometric feedbacks, i.e. the conduction and convection ones, and by the mechanoelectric feedback due to stretchactivated channels. First, the influence of such feedbacks is investigated for both a healthy and a hypertrophic fiber in case of isometric simulations. No relevant discrepancies are found when disregarding one or more feedbacks for both fibers. Then, all feedbacks are taken into account while studying the electromechanical responses of fibers. The results from isometric tests do not point out any notable difference between the healthy and hypertrophic fibers as regards the action potential duration and conduction velocity. The length-tension relationships show increased stretches and reduced peak values for tension instead. The tension-velocity relationships derived from afterloaded isotonic and quick- release tests depict higher values of contraction velocity at smaller afterloads. Moreover, higher maximum shortenings are achieved during the isotonic contraction. In conclusion, our simulation results are innovative in predicting the electromechanical behavior of eccentric hypertrophic fibers. </p></abstract>

The aim of this work is to study the effects of eccentric hypertrophy on the electromechanics of a single myocardial ventricular fiber by means of a one-dimensional finite-element strongly-coupled model. The electrical current ow model is written in the reference configuration and it is characterized by two geometric feedbacks, i.e. the conduction and convection ones, and by the mechanoelectric feedback due to stretchactivated channels. First, the influence of such feedbacks is investigated for both a healthy and a hypertrophic fiber in case of isometric simulations. No relevant discrepancies are found when disregarding one or more feedbacks for both fibers. Then, all feedbacks are taken into account while studying the electromechanical responses of fibers. The results from isometric tests do not point out any notable difference between the healthy and hypertrophic fibers as regards the action potential duration and conduction velocity. The length-tension relationships show increased stretches and reduced peak values for tension instead. The tension-velocity relationships derived from afterloaded isotonic and quick- release tests depict higher values of contraction velocity at smaller afterloads. Moreover, higher maximum shortenings are achieved during the isotonic contraction. In conclusion, our simulation results are innovative in predicting the electromechanical behavior of eccentric hypertrophic fibers.

Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy

fabrizio.delbianco01@universitadipavia.it

Communications in Applied and Industrial Mathematics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of this work is to study the effects of eccentric hypertrophy on the electromechanics of a single myocardial ventricular fiber by means of a...

Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy

Publié en ligne: 22 déc. 2017

Pages: 185 - 209

Reçu: 13 janv. 2017

Accepté: 02 août 2017

DOI: https://doi.org/10.1515/caim-2017-0010

Mots clés
electromechanical model, mechanical feedback, eccentric hypertrophy, isometric test, afterloaded isotonic test, quick-release test

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Computational modeling of the electromechanical response of a ventricular fiber affected by eccentric hypertrophy

Publié en ligne: 22 déc. 2017

Pages: 185 - 209

Reçu: 13 janv. 2017

Accepté: 02 août 2017

DOI: https://doi.org/10.1515/caim-2017-0010

Mots cléselectromechanical model, mechanical feedback, eccentric hypertrophy, isometric test, afterloaded isotonic test, quick-release test

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
electromechanical model, mechanical feedback, eccentric hypertrophy, isometric test, afterloaded isotonic test, quick-release test