Accès libre

Embryo quality predictive models based on cumulus cells gene expression

R Devjak

R Devjak

Recherchez cet auteur sur
Sciendo|Google Scholar
Devjak, R
, 
T Burnik Papler

T Burnik Papler

Recherchez cet auteur sur
Sciendo|Google Scholar
Burnik Papler, T
, 
I Verdenik

I Verdenik

Recherchez cet auteur sur
Sciendo|Google Scholar
Verdenik, I
, 
K Fon Tacer

K Fon Tacer

Recherchez cet auteur sur
Sciendo|Google Scholar
Fon Tacer, K
 et 
E Vrtačnik Bokal

E Vrtačnik Bokal

Recherchez cet auteur sur
Sciendo|Google Scholar
Vrtačnik Bokal, E
  
02 août 2016
Embryo quality predictive models based on cumulus cells gene expression's Cover Image
À propos de cet article
Article précédent
Article suivant
Citez
Télécharger la couverture
Catégorie d'article: Original Article
Publié en ligne: 02 août 2016
Pages: 5 - 12
DOI: https://doi.org/10.1515/bjmg-2016-0001
Mots clés
© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A decision tree model diagram with AMHR2 and LIF. The model first separates CC samples upon AMHR2 expression (high or low) and then upon LIF expression (high or low). The blue color represents leaves with predominantly CC of low quality embryos and red color represents leaves with predominantly CC of high quality embryos. A combination of high AMHR2 and low LIF CC expression leads to an 82.6% possibility of developing a low quality embryo, and combination of low AMHR2 and low LIF CC expression leads to 74.6% possibility of developing high quality embryos.
A decision tree model diagram with AMHR2 and LIF. The model first separates CC samples upon AMHR2 expression (high or low) and then upon LIF expression (high or low). The blue color represents leaves with predominantly CC of low quality embryos and red color represents leaves with predominantly CC of high quality embryos. A combination of high AMHR2 and low LIF CC expression leads to an 82.6% possibility of developing a low quality embryo, and combination of low AMHR2 and low LIF CC expression leads to 74.6% possibility of developing high quality embryos.

The Mann-Whitney U test results for all analyzed genes between high quality and low quality embryos (Mann-Whitney U test column); furthermore, data were split into AMHR2 high CC expression and low CC expression and analyzed using the Mann-Whitney U test (AMHR2 high group and AMHR2 low group columns)_

GeneMann-Whitney U (significance)

Significance expressed as a p value.

AMHR2 High Group (significance)

Significance expressed as a p value.

AMHR2 Low Group (significance)

Significance expressed as a p value.

AMHR20.03––
FSHR0.440.520.09
LIF0.110.030.59
SERPINE20.740.720.37
0.72VEGFC0.720.340.75

Binary logistic model for embryo outcome where age, body mass index and patient distribution were tested between high quality and low quality embryo groups_ None of the tested variables were shown to be significant in our data_

ParametersSignificance

Significance in the model expressed as a p value.

Exp(B)95% CI for Exp(B)
LowerUpper
Age0.261.100.931.28
Body mass index0.820.980.791.21
Patient0.250.930.821.05
Constant0.67
Langue:
Anglais
Périodicité:
2 fois par an
Sujets de la revue:
Médecine, Sciences médicales de base, Sciences médicales de base, autres
RSS Feed de la revue