<abstract xmlns="http://www.w3.org/1999/xhtml">Objective: This experimental study examined the effect of erythropoietin (Epo) in a rat model and particularly in an adrenal ischemia-reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean testosterone levels (T).Materials and methods: 40 rats of mean weight 247.7 g were used in the study. T levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D.Results: Erythropoietin administration non significantly increased the testosterone levels by 71.21%+44.19% (p=0.1080). Reperfusion time non-significantly decreased the testosterone levels by 65.17%+44.45% (p=0.0792). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in increasing the testosterone levels by 27.65%+27.21% (p= 0.3006).Conclusions: Erythropoietin administration whether it interacted or not with reperfusion time has increasing non significant short-term effects on testosterone levels. Perhaps, a longer study time or a higher Epo dose, may reveal clearer and more significant effects.</abstract>

Objective: This experimental study examined the effect of erythropoietin (Epo) in a rat model and particularly in an adrenal ischemia-reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean testosterone levels (T).Materials and methods: 40 rats of mean weight 247.7 g were used in the study. T levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D.Results: Erythropoietin administration non significantly increased the testosterone levels by 71.21%+44.19% (p=0.1080). Reperfusion time non-significantly decreased the testosterone levels by 65.17%+44.45% (p=0.0792). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in increasing the testosterone levels by 27.65%+27.21% (p= 0.3006).Conclusions: Erythropoietin administration whether it interacted or not with reperfusion time has increasing non significant short-term effects on testosterone levels. Perhaps, a longer study time or a higher Epo dose, may reveal clearer and more significant effects.

The Effect of Erythropoietin on Testosterone Levels During Ischemia Reperfusion Injury in Rats

Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania,

Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki,

Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki,

Department of Biologic Chemistry, Athens University, Attiki,

Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki,

ARS Medica Tomitana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objective: This experimental study examined the effect of erythropoietin (Epo) in a rat model and particularly in an adrenal ischemia-reperfusion (IR)...

The Effect of Erythropoietin on Testosterone Levels During Ischemia Reperfusion Injury in Rats

Publié en ligne: 30 mars 2017

Pages: 264 - 269

DOI: https://doi.org/10.1515/arsm-2016-0045

Mots clés
ischemia, erythropoietin, testosterone levels, reperfusion

© 2016 C. Tsompos et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Effect of Erythropoietin on Testosterone Levels During Ischemia Reperfusion Injury in Rats

Publié en ligne: 30 mars 2017

Pages: 264 - 269

DOI: https://doi.org/10.1515/arsm-2016-0045

Mots clésischemia, erythropoietin, testosterone levels, reperfusion

© 2016 C. Tsompos et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
ischemia, erythropoietin, testosterone levels, reperfusion