<abstract xmlns="http://www.w3.org/1999/xhtml">We present a case of a 51 year old multiple myeloma patient due to the complexity of his disease. After prior high dose therapy with cardiotoxic cytostatic drugs patient developed cardiac arrest due to a ventricular fibrillation. Cardiopulmonary resuscitation was successfully but the hematologist stopped the cytostatic treatment due to the high cardiac risk.The only way to control his myeloma was an autologous transplantation but this also had a very high cardiotoxic potential due to the high dose of Melphalan administered as conditioning treatment.We present the difficulties and the results of this complex case. It also arises the potential beneficial effects of the megadose of stem cells on the myocardium but this needs further studies.</abstract>

We present a case of a 51 year old multiple myeloma patient due to the complexity of his disease. After prior high dose therapy with cardiotoxic cytostatic drugs patient developed cardiac arrest due to a ventricular fibrillation. Cardiopulmonary resuscitation was successfully but the hematologist stopped the cytostatic treatment due to the high cardiac risk.The only way to control his myeloma was an autologous transplantation but this also had a very high cardiotoxic potential due to the high dose of Melphalan administered as conditioning treatment.We present the difficulties and the results of this complex case. It also arises the potential beneficial effects of the megadose of stem cells on the myocardium but this needs further studies.

Double Hematological and Cardiologic Benefits of Autologous Stem Cell Transplantation in a Case of stage III B IgG Myeloma multiplex and Dilatative Cardiomyopathy – a Case Report

Hematology and Bone Marrow Transplantation Clinic, Clinical Emergency County Hospital, Tirgu Mures, romania

Family Medicine, Dept. M3, Faculty of Medicine, University of Medicine and Pharmacy Tirgu Mures, romania

Internal Medicine, Dept. M3, Faculty of Medicine, University of Medicine and Pharmacy Tirgu Mures, romania

Cardiovascular Rehabilitation Clinic, Clinical Emergency County Hospital, Tirgu Mures, Romania

ARS Medica Tomitana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

We present a case of a 51 year old multiple myeloma patient due to the complexity of his disease. After prior high dose therapy with cardiotoxic cytostatic...

Double Hematological and Cardiologic Benefits of Autologous Stem Cell Transplantation in a Case of stage III B IgG Myeloma multiplex and Dilatative Cardiomyopathy – a Case Report

Publié en ligne: 30 déc. 2015

Pages: 223 - 226

DOI: https://doi.org/10.1515/arsm-2015-0050

Mots clés
multiple myeloma, dilatative cardiomyopathy, autologous transplantation, mega-dose of stem cells

© 2015 Benedek Lazar Erzsebet et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Double Hematological and Cardiologic Benefits of Autologous Stem Cell Transplantation in a Case of stage III B IgG Myeloma multiplex and Dilatative Cardiomyopathy – a Case Report

Publié en ligne: 30 déc. 2015

Pages: 223 - 226

DOI: https://doi.org/10.1515/arsm-2015-0050

Mots clésmultiple myeloma, dilatative cardiomyopathy, autologous transplantation, mega-dose of stem cells

© 2015 Benedek Lazar Erzsebet et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
multiple myeloma, dilatative cardiomyopathy, autologous transplantation, mega-dose of stem cells