<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Vitamin D deficiency is fequently observed in chronic kidney disease. We conducted this study to determine the concentration of the above-mentioned parameters and the correlation between them in order to optimize therapy with vitamin D in patients with end-stage renal disease (ESRD) on hemodialysis. In 53 patients on hemodialysis due to ESRD, vitamin D [Calcidiol (25(OH)D], parathyroid hormone (PTH), calcium, phosphorus, albuminuria, albumin:creatinine ratio (ACR) and other parameters have been followed up. Analysis of the levels of vitamin D has been carried out by High Performance Liquid Chromatography (HPLC), the PTH is determined by the system Centaur XP, Siemens Diagnostic, Electro-chemiluminescence immunoassay (ECLIA), and for albumin in urine we used immunological method [Miltigent microalbumin assay (Abbott Laboratories Diagnostics). We found out deficiency and insufficiency of vitamin D in 56.6% and 37.7%, as well as average 4.5 times increase in the PTH, hyperphosphatemia, hypocalcemia, albuminuria (A2 or A3), over 10 times increase in the ACR, secondary hyperparathyroidism. We registered a negative correlation between vitamin D and PTH. We confirmed the increase in creatinine and cystatin C in the patients on hemodialysis. There are few literature data for patients on hemodialysis, however, regarding the extent of the vitamin deficiency and its relationship with PTH, albuminuria, calcium, phosphorus, etc. Our data have indicated that patients on hemodialysis due to ESRD are associated with high incidence of vitamin D insufficiency or deficiency.</p></abstract>

Vitamin D deficiency is fequently observed in chronic kidney disease. We conducted this study to determine the concentration of the above-mentioned parameters and the correlation between them in order to optimize therapy with vitamin D in patients with end-stage renal disease (ESRD) on hemodialysis. In 53 patients on hemodialysis due to ESRD, vitamin D [Calcidiol (25(OH)D], parathyroid hormone (PTH), calcium, phosphorus, albuminuria, albumin:creatinine ratio (ACR) and other parameters have been followed up. Analysis of the levels of vitamin D has been carried out by High Performance Liquid Chromatography (HPLC), the PTH is determined by the system Centaur XP, Siemens Diagnostic, Electro-chemiluminescence immunoassay (ECLIA), and for albumin in urine we used immunological method [Miltigent microalbumin assay (Abbott Laboratories Diagnostics). We found out deficiency and insufficiency of vitamin D in 56.6% and 37.7%, as well as average 4.5 times increase in the PTH, hyperphosphatemia, hypocalcemia, albuminuria (A2 or A3), over 10 times increase in the ACR, secondary hyperparathyroidism. We registered a negative correlation between vitamin D and PTH. We confirmed the increase in creatinine and cystatin C in the patients on hemodialysis. There are few literature data for patients on hemodialysis, however, regarding the extent of the vitamin deficiency and its relationship with PTH, albuminuria, calcium, phosphorus, etc. Our data have indicated that patients on hemodialysis due to ESRD are associated with high incidence of vitamin D insufficiency or deficiency.

Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis

Medical Laboratory „Ramus“ – Sofia, Bulgaria

DM Medical Laboratory „Ramus“ – Sofia, Bulgaria, 2-4 Angista St. Bg - 1527 Sofia tel. 02/943-1196

Clinical Laboratory, University Hospital “Tsarista Yoanna – ISUL“ – Sofia, Bulgaria

Clinic of Haemodialysis, University Hospital “Tsarista Yoanna – ISUL” – Sofia, Bulgaria

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Vitamin D deficiency is fequently observed in chronic kidney disease. We conducted this study to determine the concentration of the above-mentioned parameters...

Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis

Publié en ligne: 20 avr. 2016

Pages: 23 - 29

DOI: https://doi.org/10.1515/amb-2016-0003

Mots clés
vitamin D, end-stage renal disease, parathyroid hormone, albuminuria, albumin: creatinine ratio in the urine, calcium, phosphorus

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Determining the Levels of Vitamin D and Parathyroid Hormone in Patients on Hemodialysis

Publié en ligne: 20 avr. 2016

Pages: 23 - 29

DOI: https://doi.org/10.1515/amb-2016-0003

Mots clésvitamin D, end-stage renal disease, parathyroid hormone, albuminuria, albumin: creatinine ratio in the urine, calcium, phosphorus

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
vitamin D, end-stage renal disease, parathyroid hormone, albuminuria, albumin: creatinine ratio in the urine, calcium, phosphorus