Regulation of the Ca_V3.2 calcium channels in health and disease Regulácia Ca_V3.2 vápnikových kanálov v zdraví a chorobe

Family of T-type or low-voltage activated calcium channels consists of three members: Ca_V3.1, Ca_V3.2, and Ca_V3.3. Ca_V3.2 channel has almost identical biophysical properties as the Ca_V3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.