<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Westernblot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.</p></abstract>

The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a mixture of 13.81 mg/kg telazol and 5.21 mg/kg xylazine, following 10 min later 0.522 mg/kg atipamezole. Thereon, the thalamencephal and cerebral cortex were removed one hour after the last injection. The level of Fos protein was measured in the brain tissue by Westernblot. The results revealed that atipamezole attenuates telazol/xylazine induction of c-fos expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole is able to inhibit telazol/xylazine-induced c-fos expression in the rat brain, thus protecting it from nerve damage.

Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

Department of Veterinary Science, Jilin Agriculture Science and Technology College, Jilin 132101, China

Key Lab of Preventive Veterinary Medicine in Jilin Province, Jilin 132101,

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030,

Department of Veterinary Science, Jilin Agriculture Science and Technology College, Jilin 132101,

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of this study was to assess whether atipamezole can restrain telazol/xylazine induced expression of c-fos in the rat brain. Rats were injected with a...

Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

Publié en ligne: 30 déc. 2016

Pages: 489 - 496

Reçu: 02 juin 2016

Accepté: 22 sept. 2016

DOI: https://doi.org/10.1515/acve-2016-0042

Mots clés
atipamezole, telazol, xylazine, rat, c-fos, brain

© by Wang Hong-Bin

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Atipamezole Attenuated Telazol/Xylazine-Induced Expression of C-Fos in Rat Thalamencephal and Cerebral Cortex

Publié en ligne: 30 déc. 2016

Pages: 489 - 496

Reçu: 02 juin 2016

Accepté: 22 sept. 2016

DOI: https://doi.org/10.1515/acve-2016-0042

Mots clésatipamezole, telazol, xylazine, rat, c-fos, brain

© by Wang Hong-Bin

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
atipamezole, telazol, xylazine, rat, c-fos, brain