<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy’s tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. S. canariensis extract, orally administrated at different doses, led to a significant reduction in writhing, caused a moderate decrease of formalin-induced pain and revealed an excellent dose-dependent anti-inflammatory effect. Bioassay-guided fractionation of the ethyl acetate extract suggested the possible presence of pentacyclic triterpenes from oleanane and ursane series. These findings allow the conclusion that S. canariensis exerts analgesic and anti-inflammatory activities, documenting its traditional use in the treatment of pain and inflammatory diseases.</p></abstract>

The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy’s tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. S. canariensis extract, orally administrated at different doses, led to a significant reduction in writhing, caused a moderate decrease of formalin-induced pain and revealed an excellent dose-dependent anti-inflammatory effect. Bioassay-guided fractionation of the ethyl acetate extract suggested the possible presence of pentacyclic triterpenes from oleanane and ursane series. These findings allow the conclusion that S. canariensis exerts analgesic and anti-inflammatory activities, documenting its traditional use in the treatment of pain and inflammatory diseases.

The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The...

The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species

Article Category: Short communication

Publié en ligne: 01 juin 2017

Pages: 265 - 273

Accepté: 28 déc. 2016

DOI: https://doi.org/10.1515/acph-2017-0012

Mots clés
Salix canariensis, analgesic activity, anti-inflammatory activity, bioassay fractionation, pentacyclic triterpenes, ursanes, oleananes

© by Sandra Dévora Gutiérrez

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species

Article Category: Short communication

Publié en ligne: 01 juin 2017

Pages: 265 - 273

Accepté: 28 déc. 2016

DOI: https://doi.org/10.1515/acph-2017-0012

Mots clésSalix canariensis, analgesic activity, anti-inflammatory activity, bioassay fractionation, pentacyclic triterpenes, ursanes, oleananes

© by Sandra Dévora Gutiérrez

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
Salix canariensis, analgesic activity, anti-inflammatory activity, bioassay fractionation, pentacyclic triterpenes, ursanes, oleananes