<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, and samples were analysed using a validated HPLC method. The dissolution profile of each marker varied for the different materials investigated. All three media utilised showed differences in flavonoid glycoside dissolution between the S. frutescens products evaluated, with f<sub>2</sub> values &lt; 50 for comparison of flavonoid dissolution from any two of the materials. Dissolution of S. frutescens materials could thus be characterised using the markers in all the media tested. This tool may be employed in the future for comparison of orally administered S. frutescens products, provided between- batch variability is evaluated and found less than between-sample variability.</p></abstract>

Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, and samples were analysed using a validated HPLC method. The dissolution profile of each marker varied for the different materials investigated. All three media utilised showed differences in flavonoid glycoside dissolution between the S. frutescens products evaluated, with f2 values < 50 for comparison of flavonoid dissolution from any two of the materials. Dissolution of S. frutescens materials could thus be characterised using the markers in all the media tested. This tool may be employed in the future for comparison of orally administered S. frutescens products, provided between- batch variability is evaluated and found less than between-sample variability.

Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in...

Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products

Article Category: Short communication

Publié en ligne: 21 févr. 2017

Pages: 137 - 146

Accepté: 03 août 2016

DOI: https://doi.org/10.1515/acph-2017-0003

Mots clés
Sutherlandia frutescens, herbal products, dissolution testing, flavonoid, discriminatory medium, similarity factor

© by Oluchi N. Mbamalu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products

Article Category: Short communication

Publié en ligne: 21 févr. 2017

Pages: 137 - 146

Accepté: 03 août 2016

DOI: https://doi.org/10.1515/acph-2017-0003

Mots clésSutherlandia frutescens, herbal products, dissolution testing, flavonoid, discriminatory medium, similarity factor

© by Oluchi N. Mbamalu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
Sutherlandia frutescens, herbal products, dissolution testing, flavonoid, discriminatory medium, similarity factor