<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome- -based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment. </p></abstract>

A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome- -based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment.

Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment

School of Pharmacy, Jiangsu University, Zhenjiang Jiangsu 212013, China

Institute of Life Sciences Jiangsu University, Zhenjiang Jiangsu 212013, China

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry...

Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment

Publié en ligne: 23 mai 2015

Pages: 105 - 116

Accepté: 09 févr. 2015

DOI: https://doi.org/10.1515/acph-2015-0019

Mots clés
virosome, drug delivery system, cancer treatment, cancer vaccine

© by Zhigang Tu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment

Publié en ligne: 23 mai 2015

Pages: 105 - 116

Accepté: 09 févr. 2015

DOI: https://doi.org/10.1515/acph-2015-0019

Mots clésvirosome, drug delivery system, cancer treatment, cancer vaccine

© by Zhigang Tu

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
virosome, drug delivery system, cancer treatment, cancer vaccine