<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p &lt; 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin</p></abstract>

Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin

Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

Istanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, Turkey

Istanbul University Faculty of Pharmacy Department of Analytical Chemistry Istanbul, Turkey

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and...

Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

Publié en ligne: 11 mars 2015

Pages: 1 - 13

Reçu: 23 oct. 2014

DOI: https://doi.org/10.1515/acph-2015-0009

Mots clés
lornoxicam, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsion, transdermal delivery, inflammation

© by Melike Üner

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

Publié en ligne: 11 mars 2015

Pages: 1 - 13

Reçu: 23 oct. 2014

DOI: https://doi.org/10.1515/acph-2015-0009

Mots cléslornoxicam, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsion, transdermal delivery, inflammation

© by Melike Üner

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
lornoxicam, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsion, transdermal delivery, inflammation