<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers - gelatine discs, mucin gel and porcine stomach mucosa. Microspheres showed a smooth surface with narrow particle size distribution and RNT loading of up to 70.9 %. All formulations possessed mucoadhesive properties and exhibited prolonged drug release according to the first-order kinetics. DSC reports showed that there was no interaction between RNT and ALG. Designed microspheres can be considered potential carriers of ranitidine with prolonged residence time in the stomach</p></abstract>

The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers - gelatine discs, mucin gel and porcine stomach mucosa. Microspheres showed a smooth surface with narrow particle size distribution and RNT loading of up to 70.9 %. All formulations possessed mucoadhesive properties and exhibited prolonged drug release according to the first-order kinetics. DSC reports showed that there was no interaction between RNT and ALG. Designed microspheres can be considered potential carriers of ranitidine with prolonged residence time in the stomach

Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

Department of Pharmaceutical Technology Medical University of Białystok 15-222 Białystok, Poland

Department of Pharmaceutical Technology Medical University of Białystok 15-222 Białystok, Poland / Department of Clinical Pharmacy Medical University of Białystok 15-222 Białystok, Poland

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were...

Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

Publié en ligne: 11 mars 2015

Pages: 15 - 27

Reçu: 24 oct. 2014

DOI: https://doi.org/10.1515/acph-2015-0008

Mots clés
ranitidine, sodium alginate, microspheres, spray drying technique, mucoadhesiveness

© by Katarzyna Winnicka

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine

Publié en ligne: 11 mars 2015

Pages: 15 - 27

Reçu: 24 oct. 2014

DOI: https://doi.org/10.1515/acph-2015-0008

Mots clésranitidine, sodium alginate, microspheres, spray drying technique, mucoadhesiveness

© by Katarzyna Winnicka

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
ranitidine, sodium alginate, microspheres, spray drying technique, mucoadhesiveness