<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl dibehenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl dibehenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder used</p></abstract>

The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl dibehenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl dibehenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder used

Compressibility of tableting materials and properties of tablets with glyceryl behenate

Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

Department of Physical Chemistry University of Pardubice, Faculty of Chemical Technology, Pardubice Czech Republic

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and...

Compressibility of tableting materials and properties of tablets with glyceryl behenate

Publié en ligne: 11 mars 2015

Pages: 91 - 98

Reçu: 14 oct. 2014

DOI: https://doi.org/10.1515/acph-2015-0006

Mots clés
lipophilic matrix tablet, glyceryl dibehenate, salicylic acid, energy profile of compression, tensile strength of tablets, dissolution profile

© by Jitka Mužíková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Compressibility of tableting materials and properties of tablets with glyceryl behenate

Publié en ligne: 11 mars 2015

Pages: 91 - 98

Reçu: 14 oct. 2014

DOI: https://doi.org/10.1515/acph-2015-0006

Mots cléslipophilic matrix tablet, glyceryl dibehenate, salicylic acid, energy profile of compression, tensile strength of tablets, dissolution profile

© by Jitka Mužíková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
lipophilic matrix tablet, glyceryl dibehenate, salicylic acid, energy profile of compression, tensile strength of tablets, dissolution profile