<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>Gastrointestinal stromal tumor (GIST) was the most common mesenchymal tumor of the gastrointestinal tract predominately occurring in the stomach. Although GIST was a rare disease, it was considered to be a life-threatening malignancy.</p></sec><sec><h3>Objective</h3><p>To explore the current status of gastric GIST in Thai patients.</p></sec><sec><h3>Method</h3><p>The medical records of patients who were diagnosed with histologically proven gastric GIST from 2012 to 2016 in King Chulalongkorn Memorial Hospital were reviewed.</p></sec><sec><h3>Results</h3><p>Of 22 patients, there were 14 (63.6%) females and 8 (36.4%) males with the mean age of 62.6 ± 14.8 years. The average duration before the first presentation was 12 weeks. The initial symptoms were upper gastrointestinal bleeding (50.0%) followed by abdominal pain (31.8%). Tumor mostly located at the proximal part (fundus and cardia) in 20 (90.9%) patients. At the time of the diagnosis, three patients (13.6%) had distant metastasis. Of this group, 77.3% underwent surgical treatment.</p></sec><sec><h3>Discussion</h3><p>Although gastric GIST was an uncommon disease, early diagnosis and prompt treatment could save the lives of many patients.</p></sec></abstract>

BackgroundGastrointestinal stromal tumor (GIST) was the most common mesenchymal tumor of the gastrointestinal tract predominately occurring in the stomach. Although GIST was a rare disease, it was considered to be a life-threatening malignancy.ObjectiveTo explore the current status of gastric GIST in Thai patients.MethodThe medical records of patients who were diagnosed with histologically proven gastric GIST from 2012 to 2016 in King Chulalongkorn Memorial Hospital were reviewed.ResultsOf 22 patients, there were 14 (63.6%) females and 8 (36.4%) males with the mean age of 62.6 ± 14.8 years. The average duration before the first presentation was 12 weeks. The initial symptoms were upper gastrointestinal bleeding (50.0%) followed by abdominal pain (31.8%). Tumor mostly located at the proximal part (fundus and cardia) in 20 (90.9%) patients. At the time of the diagnosis, three patients (13.6%) had distant metastasis. Of this group, 77.3% underwent surgical treatment.DiscussionAlthough gastric GIST was an uncommon disease, early diagnosis and prompt treatment could save the lives of many patients.

Clinical features and immunohistochemistry profile of biopsy-proven gastric gastrointestinal stromal tumor (GIST): a description of 5 years case series and literature review of GIST

Department of Physiology, Faculty of Medicine

Department of Pathology, Faculty of Medicine

Department of Medicine, Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundGastrointestinal stromal tumor (GIST) was the most common mesenchymal tumor of the gastrointestinal tract predominately occurring in the stomach....

Clinical features and immunohistochemistry profile of biopsy-proven gastric gastrointestinal stromal tumor (GIST): a description of 5 years case series and literature review of GIST

Article Category: Brief communication (original)

Publié en ligne: 10 sept. 2020

Pages: 111 - 117

DOI: https://doi.org/10.1515/abm-2020-0017

Mots clés
gastric, gastrointestinal stromal tumor, stomach

© 2020 Chuthamas Ongprakobkul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Clinical features and immunohistochemistry profile of biopsy-proven gastric gastrointestinal stromal tumor (GIST): a description of 5 years case series and literature review of GIST

Article Category: Brief communication (original)

Publié en ligne: 10 sept. 2020

Pages: 111 - 117

DOI: https://doi.org/10.1515/abm-2020-0017

Mots clésgastric, gastrointestinal stromal tumor, stomach

© 2020 Chuthamas Ongprakobkul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
gastric, gastrointestinal stromal tumor, stomach