<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_abm-2019-0046_s_006_w2aab2b8b7b1b7b1aab1c14b1Aa"><h3>Background</h3><p>While numerous randomized controlled trials have demonstrated long-term survival rates for patients with early-stage breast cancer treated with breast-conserving surgery (BCS) comparable to mastectomy, the latter remains the most prevalent surgical option to treat early-stage breast cancer in Thailand.</p></sec><sec id="j_abm-2019-0046_s_007_w2aab2b8b7b1b7b1aab1c14b2Aa"><h3>Objectives</h3><p>To investigate the potential determinants affecting the decision on selecting BCS or mastectomy for the treatment of early-stage breast cancer and to compare the disease-free survival and overall survival between the treatments using a propensity score-matched analysis.</p></sec><sec id="j_abm-2019-0046_s_008_w2aab2b8b7b1b7b1aab1c14b3Aa"><h3>Methods</h3><p>Patients diagnosed nonmetastatic breast cancer at the Queen Sirikit Breast Cancer Center from January 2006 to December 2015, were retrospectively identified and grouped intro patients who received BCS or mastectomy. After propensity score matching, 356 BCS and 209 mastectomy patients were identified, and statistical analysis was conducted to determine treatment selection factors and compare disease-free and overall survival.</p></sec><sec id="j_abm-2019-0046_s_009_w2aab2b8b7b1b7b1aab1c14b4Aa"><h3>Results</h3><p>Disease-free survival and overall survival in months comparing BCS and mastectomy were not statistically different with <italic>P</italic> values of 0.11 and 0.77, respectively. Determinants of treatment selection found that younger age, surgeon preference, smaller tumor size, and lower tumor grade were statistically significant factors in the selection of BCS over mastectomy. The majority of surgeons had a preference for one treatment over the other (<italic>P</italic> &lt; 0.001).</p></sec><sec id="j_abm-2019-0046_s_010_w2aab2b8b7b1b7b1aab1c14b5Aa"><h3>Conclusion</h3><p>The outcome of BCS is comparable to mastectomy in early-stage breast cancer patients. Key determinants affecting the selection of treatment were identified to be patient age, characteristics of the tumor, and surgeon’s preference.</p></sec></abstract>

BackgroundWhile numerous randomized controlled trials have demonstrated long-term survival rates for patients with early-stage breast cancer treated with breast-conserving surgery (BCS) comparable to mastectomy, the latter remains the most prevalent surgical option to treat early-stage breast cancer in Thailand.ObjectivesTo investigate the potential determinants affecting the decision on selecting BCS or mastectomy for the treatment of early-stage breast cancer and to compare the disease-free survival and overall survival between the treatments using a propensity score-matched analysis.MethodsPatients diagnosed nonmetastatic breast cancer at the Queen Sirikit Breast Cancer Center from January 2006 to December 2015, were retrospectively identified and grouped intro patients who received BCS or mastectomy. After propensity score matching, 356 BCS and 209 mastectomy patients were identified, and statistical analysis was conducted to determine treatment selection factors and compare disease-free and overall survival.ResultsDisease-free survival and overall survival in months comparing BCS and mastectomy were not statistically different with P values of 0.11 and 0.77, respectively. Determinants of treatment selection found that younger age, surgeon preference, smaller tumor size, and lower tumor grade were statistically significant factors in the selection of BCS over mastectomy. The majority of surgeons had a preference for one treatment over the other (P < 0.001).ConclusionThe outcome of BCS is comparable to mastectomy in early-stage breast cancer patients. Key determinants affecting the selection of treatment were identified to be patient age, characteristics of the tumor, and surgeon’s preference.

Clinical outcomes and surgical preferences for breast-conserving surgery and mastectomy: a propensity score-matched analysis

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

BackgroundWhile numerous randomized controlled trials have demonstrated long-term survival rates for patients with early-stage breast cancer treated with...

Clinical outcomes and surgical preferences for breast-conserving surgery and mastectomy: a propensity score-matched analysis

Article Category: Brief communication (original)

Publié en ligne: 30 déc. 2019

Pages: 95 - 100

DOI: https://doi.org/10.1515/abm-2019-0046

Mots clés
breast-conserving surgery, mastectomy, retrospective study

© 2019 Mawin Vongsaisuwon et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Clinical outcomes and surgical preferences for breast-conserving surgery and mastectomy: a propensity score-matched analysis

Article Category: Brief communication (original)

Publié en ligne: 30 déc. 2019

Pages: 95 - 100

DOI: https://doi.org/10.1515/abm-2019-0046

Mots clésbreast-conserving surgery, mastectomy, retrospective study

© 2019 Mawin Vongsaisuwon et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
breast-conserving surgery, mastectomy, retrospective study