Sodium glycerophosphate and prescribed calcium concentrations in pediatric parenteral nutrition: a retrospective observational study and economic evaluation

Characteristics	Number of orders (%)
Sex
Male	1,154 (52.6)
Female	1,038 (47.4)
Age
Newborn to 12 months	1,859 (84.8)
>12 months	333 (15.2)
Primary medical conditions
Short bowel syndrome	220 (10.0)
Preterm or very low-birth-weight infant	837 (38.2)
Others*	1,096 (50.0)
Not specified	39 (1.8)
Nutritional assessment according to pediatricians
Normal	6 (0.3)
Mild malnutrition	1,212 (55.3)
Moderate malnutrition	518 (23.6)
Severe malnutrition	209 (9.5)
Not specified	247 (11.3)

Mineral and amino acid concentrations prescribed in preterm infants

Phosphate products (No. orders)	Data shown as median (25th percentile–75th percentile) [minimum, maximum]
	Calcium (mmol/L)	Phosphorus (mmol/L)	Sodium (mmol/L)	Potassium (mmol/L)	Magnesium (mmol/L)	Trace element (mL/L)	Amino acid (%)
NaGlyP
Central line	29.36	17.00	35.56	25.45	2.58	12.50	2.72
(227)	(22.27–37.99)	(12.07–23.50)	(26.67–50.91)	(18.18–33.33)	(1.84–3.24)	(9.11–15.58)	(2.00–3.83)
	[2.37, 83.25]	[1.74, 50.00]	[3.48, 118.81]	[0.00, 112.06]	[0.00, 9.64]	[6.25, 37.50]	[0.63, 11.25]
Peripheral line	30.00	18.93	38.75	26.20	2.48	12.29	3.00
(362)	(24.19–39.63)	(14.01–25.00)	(29.20–48.47)	(20.00–34.00)	(1.97–3.32)	(9.85–16.52)	(2.33–3.69)
	[3.60, 75.09]	[2.82, 50.00]	[11.82, 100.00]	[0.00, 65.00]	[0.00, 40.5]	[6.36, 115.00]	[0.70, 8.25]

Minerals and amino acid concentrations prescribed in all pediatrie parenteral nutrition orders

Phosphate product	Orders (n)	Orders that required reduced calcium concentration (%)	Data shown as median (25th percentile-75th percentile) [minimum, maximum]
			Calcium (mmol/L)	Phosphorus (mmol/L)	Sodium (mmol/L)	Potassium (mmol/L)	Magnesium (mmol/L)	Trace element (mL/L)	Amino acid (%)
Central line	1,347
NaGlyP	1,289	1 (0.1)	12.98	11.00	37.22	28.97	2.55	12.50	3.03
			(5.82-25.04)	(4.80-18.68)	(25.83-58.00)	(19.05-40.80)	(1.84-4.05)	(9.17-16.67)	(2.31-4.40)
			[0.84,139.91]	[1.65,83.64]	[3.48,426.67]	[0.00, 250.00]	[0.00,40.50]	[0.00,100.00]	[0.00,11.25]
Dipotassium	52	23 (44.2)	2.90	11.58	11.75	34.62	3.16	16.59	3.50
phosphate			(1.68-5.86)	(6.91-16.53)	(5.31-22.68)	(20.26-66.02)	(1.92-3.63)	(13.08-22.27)	(2.5-4.21)
			[0.00,12.21]	[2.63, 56.04]	[0.00,114.87]	[7.75,188.46]	[0.00,12.89]	[7.93, 37.50]	[0.95,6.00]
Mixed both	6	3(50)	2.23	22.86	31.33	27.49	2.09	9.47	2.00
phosphate salts			(1.99-6.83)	(15.20-23.21)	(19.46-41.00)	(19.46-37.08)	(1.77-3.75)	(7.14-13.22)	(1.79-2.06)
			[1.82,26.57]	[11.38,23.92]	[8.62,57.14]	[5.17,60.95]	[1.35,10.03]	[0.00, 33.33]	[1.67,2.83]
^*P			<0.001	0.11	<0.001	0.08	0.83	<0.001	0.02
Peripheral line	845
NaGlyP	839	0(0.)	27.00	17.27	37.26	25.55	2.36	11.58	2.80
			(20.28-35.76)	(12.42-22.67)	(28.48-48.47)	(19.07-33.33)	(1.80-3.13)	(9.17-15.20)	(2.13-3.53)
			[1.69,119.86]	[1.50,96.36]	[3.65,192.73]	[0.00,357.14]	[0.00,90.00]	[0.00,115.00]	[0.65, 27.5]
Dipotassium	3	2(67)	1.95	8.22	27.43	32.89	1.66	16.47	3.29
phosphate			(1.95-2.64)	(7.28-8.22)	(24.30-31.44)	(29.14-32.89)	(1.48-1.66)	(14.60-16.47)	(2.92-3.29)
			[1.95,3.33]	[6.35,8.22]	[21.17,35.44]	[25.39, 32.89]	[1.30,1.67]	[12.73,16.47]	[2.55, 3.29]
Mixed both	3	0(0)	6.44	12.94	24.29	25.88	2.62	12.92	3.23
phosphate salts			(5.94-7.66)	(11.93-15.35)	(18.64-33.68)	(23.56-30.70)	(2.42-3.12)	(11.90-15.32)	(2.70-3.83)
			[5.44,8.88]	[10.92,17.76]	[22.67, 38.46]	[21.83,35.53]	[2.23, 3.62]	[10.88,17.71]	[2.17,4.43]
^*p			<0.001	0.03	0.11	0.12	0.02	0.06	0.66

Costs of phosphate products used per bag

Phosphate products	Costs (USD)/bag median (25th percentile–75th percentile) [minimum, maximum]	Costs (THB)/bag median (25th percentile–75th percentile) [minimum, maximum]
NaGlyP	1.04	35.88
	(0.77–1.45)	(26.22–49.68)
	[0.16, 32.77]	[5.52, 1,121.94]
Dipotassium	1.20	41.25
phosphate	(0.56–1.57)	(19.35–53.66)
	[0.26, 14.34]	[9.13, 490.93]
Mixed both	2.03	69.63
phosphate salts	(1.58–2.11)	(53.97–72.22)
	[0.59, 5.48]	[20.25, 187.96]
P*	0.03	0.03

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Sodium glycerophosphate and prescribed calcium concentrations in pediatric parenteral nutrition: a retrospective observational study and economic evaluation

Article Category: Brief communication (original)

Publié en ligne: 01 oct. 2019

Pages: 229 - 235

DOI: https://doi.org/10.1515/abm-2019-0024

Mots clésalpha-glycerophosphoric acid, glycerophosphates, calcium, chemical precipitation, parenteral nutrition, phosphates

© 2018 Siritientong and Nimitwongsin, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Demographic data of pediatric patients in 2,192 parenteral nutrition orders

Mineral and amino acid concentrations prescribed in preterm infants

Minerals and amino acid concentrations prescribed in all pediatrie parenteral nutrition orders

Costs of phosphate products used per bag

Mots clés
alpha-glycerophosphoric acid, glycerophosphates, calcium, chemical precipitation, parenteral nutrition, phosphates