Accès libre

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Pei Ling Yeo

Pei Ling Yeo

Division of Applied Biomedical Science and Biotechnology, International Medical UniversityBukit Jalil, Malaysia
Recherchez cet auteur sur
Sciendo|Google Scholar
Yeo, Pei Ling
, 
Chooi Ling Lim

Chooi Ling Lim

Division of Applied Biomedical Science and Biotechnology, International Medical UniversityBukit Jalil, Malaysia
Recherchez cet auteur sur
Sciendo|Google Scholar
Lim, Chooi Ling
, 
Soi Moi Chye

Soi Moi Chye

Division of Applied Biomedical Science and Biotechnology, International Medical UniversityBukit Jalil, Malaysia
Recherchez cet auteur sur
Sciendo|Google Scholar
Chye, Soi Moi
, 
Anna Pick Kiong Ling

Anna Pick Kiong Ling

Division of Applied Biomedical Science and Biotechnology, International Medical UniversityBukit Jalil, Malaysia
Recherchez cet auteur sur
Sciendo|Google Scholar
Kiong Ling, Anna Pick
 et 
Rhun Yian Koh

Rhun Yian Koh

Division of Applied Biomedical Science and Biotechnology, International Medical UniversityBukit Jalil, Malaysia
Recherchez cet auteur sur
Sciendo|Google Scholar
Koh, Rhun Yian
  
21 mars 2018
Niosomes: a review of their structure, properties, methods of preparation, and medical applications's Cover Image
À propos de cet article
Article précédent
Article suivant
Citez
Télécharger la couverture
Catégorie d'article: Review article
Publié en ligne: 21 mars 2018
Pages: 301 - 314
DOI: https://doi.org/10.1515/abm-2018-0002
Mots clés
© 2017 Pei Ling Yeo, Chooi Ling Lim, Soi Moi Chye, Anna Pick Kiong Ling, Rhun Yian Koh
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Figure 1

Structure of a niosome
Structure of a niosome

Figure 2

Schematic diagram of preparation of niosomes using the reverse-phase evaporation technique
Schematic diagram of preparation of niosomes using the reverse-phase evaporation technique

Figure 3

Schematic diagram of preparation of niosomes using the “bubble” method
Schematic diagram of preparation of niosomes using the “bubble” method

Figure 4

Schematic diagram of preparation of niosomes by transmembrane pH gradient (inside acidic) drug uptake process
Schematic diagram of preparation of niosomes by transmembrane pH gradient (inside acidic) drug uptake process

Drugs/compounds encapsulated in niosomes and their antibacterial or antifungal effects

Drug/compound(s)Effects compared with unencapsulated formReference(s)
ItraconazoleGreater activity against Candida albicans[100]
Diallyl disulfideGreater activity against C. albicans[101]
FluconazoleEffective against corneal fungal infections[102]
MiconazoleEffective against Trichophyton rubrum[103]
Nisin and ethylenediaminetetraacetic acidBetter effect in inhibiting Staphylococcus aureus[106]
GalliderminBetter antibacterial effects against Propionibacterium acnes and S. aureus[108]
PropolisEnhanced antimicrobial effect[110]
GatifloxacinEffective against ocular infections[111]
MoxifloxacinUsed for topical microbial infections[112]
Bismuth-ethanedithiol and tobramycinEffective against Pseudomonas aeruginosa[114]

Drugs/compounds encapsulated in niosomes and their anticancer effects

Drug/compound(s)EffectsReference(s)
DoxorubicinDecreased proliferation of sarcoma cells[26, 57]
Daunorubicin hydrochlorideDestroyed Dalton’s ascitic lymphoma cells[52]
BleomycinAccumulated in higher levels at the tumor site[52]
MethotrexateEnhanced antitumor activity against sarcoma[58]
5-FluorouracilEnhanced drug penetration in the treatment of skin cancer[59]
VincristineEnhanced antitumor activity against sarcoma[5]
TocotrienolEnhanced cytotoxicity toward breast cancer cells[61]
CurcuminEnhanced cytotoxic and apoptotic effects toward ovarian cancer cells[63]
Curcumin and doxorubicin hydrochlorideEnhanced cytotoxicity toward cervical cancer cells[64]
ArtemisininCytotoxic toward melanoma cells[68]
Tamoxifen citrateGreater cytotoxicity against breast cancer cell line[70]
MitoxantroneGreater cytotoxicity against human ovarian cancer and breast cancer cell lines[71]
CisplatinEnhanced cytotoxicity toward breast cancer cells[73]
Langue:
Anglais
Périodicité:
6 fois par an
Sujets de la revue:
Médecine, Professions d'assistance, soins infirmiers, Sciences médicales de base, Sciences médicales de base, autres, Médecine clinique, Médecine clinique, autres
RSS Feed de la revue