<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The pharmacokinetics of ferrous methionate and ferrous sulphate was investigated in broiler chickens after intravenous injection and crop intubation. The iron compounds were injected intravenously in v. brachialis. After a 20-day “wash-out” period the ferrous methionate and ferrous sulphate were administered again by an elastic silicone tube into the crop. The serum concentrations of the iron were determined using a bioanalyser. Two pharmacokinetic approaches were used - compartmental and non-compartmental analysis. After i.v. injection we found statistically significantly longer and better distribution of the iron contained in the ferrous methionate compared to the ferrous sulphate. The АUC<sub>0→∞</sub> was statistically significantly higher in the ferrous methionate. In the alimentary tract of broiler chickens, ferrous methionate was absorbed more rapidly than ferrous sulfate. It was also distributed at a higher volume as compared to the ferrous sulfate</p></abstract>

The pharmacokinetics of ferrous methionate and ferrous sulphate was investigated in broiler chickens after intravenous injection and crop intubation. The iron compounds were injected intravenously in v. brachialis. After a 20-day “wash-out” period the ferrous methionate and ferrous sulphate were administered again by an elastic silicone tube into the crop. The serum concentrations of the iron were determined using a bioanalyser. Two pharmacokinetic approaches were used - compartmental and non-compartmental analysis. After i.v. injection we found statistically significantly longer and better distribution of the iron contained in the ferrous methionate compared to the ferrous sulphate. The АUC0→∞ was statistically significantly higher in the ferrous methionate. In the alimentary tract of broiler chickens, ferrous methionate was absorbed more rapidly than ferrous sulfate. It was also distributed at a higher volume as compared to the ferrous sulfate

Comparative Study of the Pharmacokinetics of Inorganic and Organic Iron Compounds in Broiler Chickens

Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria

Department of Non-infectious Diseases and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, Sofi a, Bulgaria

Medical Diagnostic Laboratory “Chemalab-2003”, Sofi a, Bulgaria

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The pharmacokinetics of ferrous methionate and ferrous sulphate was investigated in broiler chickens after intravenous injection and crop intubation. The iron...

Comparative Study of the Pharmacokinetics of Inorganic and Organic Iron Compounds in Broiler Chickens

Publié en ligne: 18 nov. 2015

Pages: 75 - 81

Reçu: 21 oct. 2013

Accepté: 08 janv. 2014

DOI: https://doi.org/10.14432/j.macvetrev.2014.01.008

Mots clés
pharmacokinetics, ferrous sulphate, ferrous methionate, chickens

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Comparative Study of the Pharmacokinetics of Inorganic and Organic Iron Compounds in Broiler Chickens

Publié en ligne: 18 nov. 2015

Pages: 75 - 81

Reçu: 21 oct. 2013

Accepté: 08 janv. 2014

DOI: https://doi.org/10.14432/j.macvetrev.2014.01.008

Mots cléspharmacokinetics, ferrous sulphate, ferrous methionate, chickens

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
pharmacokinetics, ferrous sulphate, ferrous methionate, chickens