- Detalles de la revista
- Formato
- Revista
- eISSN
- 2501-062X
- Publicado por primera vez
- 30 Mar 2015
- Periodo de publicación
- 4 veces al año
- Idiomas
- Inglés
Buscar
- Acceso abierto
Confounding in the hyponatremia, bone mineral density and falls relationship
Páginas: 207 - 208
Resumen
- Acceso abierto
Non-alcoholic fatty pancreas disease – practices for clinicians
Páginas: 209 - 219
Resumen
Obesity is a growing health burden worldwide, increasing the risk for several diseases featuring the metabolic syndrome – type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease and cardiovascular diseases. With the increasing epidemic of obesity, a new pathologic condition has emerged as a component of the metabolic syndrome – that of non-alcoholic fatty pancreas disease (NAFPD). Similar to non-alcoholic fatty liver disease (NAFLD), NAFPD comprises a wide spectrum of disease – from deposition of fat in the pancreas – fatty pancreas, to pancreatic inflammation and possibly pancreatic fibrosis. In contrast with NAFLD, diagnostic evaluation of NAFPD is less standardized, consisting mostly in imaging methods. Also the natural evolution of NAFPD and its association with pancreatic cancer is much less studied. Not least, the clinical consequences of NAFPD remain largely presumptions and knowledge about its metabolic impact is limited. This review will cover epidemiology, pathogenesis, diagnostic evaluation tools and treatment options for NAFPD, with focus on practices for clinicians.
Palabras clave
- non-alcoholic fatty pancreas
- metabolic syndrome
- diabetes mellitus
- Acceso abierto
Medical evaluation and management of male and female voiding dysfunction: a review
Páginas: 220 - 232
Resumen
A significant workforce shortage of urologists available to serve the US population has been projected to occur over the next decade. Accordingly, much of the management of urologic patients will need to be assumed by other specialties and practitioners. Since primary care physicians are often first evaluate common urologic complaints, it makes sense that these physicians are in an excellent position to intervene in the management of these patients when appropriate. One of the most common complaints in urology is voiding dysfunction. The incidence of voiding dysfunction increases with age, with conservative estimates showing that over 50% of elderly patients suffer. Despite this high prevalence and its negative impact on quality of life, however, few seek or receive treatment, as many do not readily disclose these impactful yet personal symptoms. We sought to summarize the typical presentation, evaluation, assessment and therapeutic options for both male and female patients presenting with voiding dysfunction.
Palabras clave
- urology
- urinary incontinence
- referral and consultation
- urination disorders
- disease management
- Acceso abierto
Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes
Páginas: 233 - 240
Resumen
L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin 1(SIRT1). Moreover, recent evidences strongly suggest that SIRT1 up-regulation may serve as a potent therapeutic approach against development and progression of diabetic complications. The aim of this study was to investigate L effects directed on the pro-inflammatory NF-kB pathway and expression of SIRT1 in obese patients with type 2 diabetes mellitus (DM).
Palabras clave
- glucagon-like peptide 1 (GLP-1)
- liraglutide
- diabetes
- obesity
- NF-kB
- SIRT1
- mediators of inflammation
- Acceso abierto
A prospective study of hospitalized patients with leukemoid reaction; causes, prognosis and value of manual peripheral smear review
Páginas: 241 - 247
Resumen
Palabras clave
- leukocytosis
- causes
- prognosis
- blood smear
- neutrophilia
- Acceso abierto
The changing pattern of fever of unknown origin in the Republic of North Macedonia
Páginas: 248 - 253
Resumen
Palabras clave
- Adult onset Still disease
- Diagnosis
- Fever
- Infection
- Neoplasm
- Acceso abierto
Prognostic factors in glomerular diseases with crescents
Páginas: 254 - 261
Resumen
Palabras clave
- Acute kidney injury
- glomerulonephritis
- glomerulosclerosis
- kidney failure
- treatment outcome
- Acceso abierto
Hypokalemic periodic paralysis – the importance of patient education
Páginas: 263 - 265
Resumen
Hypokalemic periodic paralysis (HOKPP) is a rare neuromuscular disorder caused by altered transport of cellular potassium that leads to significant muscle weakness of the extremities. Paralytic attacks are induced by a drop in the serum potassium level and they have been associated with specific triggers. This case describes a 21-year-old male who has had recurrent presentations of acute paralytic attacks following vigorous physical activity. At presentation, this patient exhibited flaccid paralysis of all skeletal muscles below the neck, but was alert and oriented with stable vital signs. The patient was found to have a potassium level of 2.1 mmol/L and an EKG demonstrating U waves (characteristic of hypokalemia). The patient was treated with potassium supplementation with resolution of symptoms. The mainstay of prevention of long term permanent muscle weakness is avoidance of triggers that can lead to hypokalemia. Through education on disease process and lifestyle modifications, we were able to end the cycle of recurrent hospital readmissions and the subsequent financial burden this generated for the patient and his family.
Palabras clave
- hypokalemia
- periodic paralysis
- neuromuscular disorders
- muscle weakness
- Acceso abierto
Crowned dens syndrome presenting as pyrexia of unknown origin (PUO)
Páginas: 266 - 269
Resumen
Palabras clave
- crowned dens syndrome
- fever
- elderly