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Cancer is a common disease that people dread, and most of them fully believe that they will be sentenced to death along with the diagnosis. The aim of the present study was to set up a dietary survey and nutritional therapy pattern that can be used in Romania for patients diagnosed with cervical cancer, that will contribute to a better management of the mentioned disease cervical cancer. This diet therapy can help patients to recover easily from cervical cancer, prevent cancer weakening and weight loss, and to fight strenuous medical treatments that can further worsen their overall condition and quality of life. Furthermore, this nutrition intervention can reduce malnutrition outcomes and establishes a diet plan that makes easier for the patients to endure the symptoms and reduces the side effects of multiple cancer treatments. The backbone of our paper was the National Cancer Institute’s Nutritional PDQ (Physician Data Query), an american institute that conducts cancer screening and daily information of cancer researchers along with other recent literature sources.
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„George Emil Palade” Marosvásárhelyi Orvosi, Gyógyszerészeti, Tudomány- és Technológiai Egyetem

Biokémia és Környezeti Tényezők Kémiája Tanszék

Köztáplálkozás és Táplálékok Higiéniája Tanszék

Setting up a personalized regenerative diet for Romanian patients with cervical cancer based on a regional preventive screening program

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Zoltán Vámossy (1868–1953), with Transylvanian roots, became a doctor 130 years ago, in 1891, at the University of Budapest. Later, from 1898, he was appointed a private university professor of Pharmacology, from 1908 a public university professor, and from 1920 to 1938 he was director of the Institute of pharmacology. In the meantime, from 1922 to 1924, he also held the position of dean of the Faculty of Medicine. He was elected a corresponding member of the Hungarian Academy of Sciences on May 5, 1920, but on April 23, 1948 his membership was terminated for political reasons. It was not restored until after his death, on 9 May 1991. Afterwards he taught even in the 1945/46 school year. He was an understanding and helpful instructor for the university students, so he was respected, appreciated, and loved. His professional life was filled with university education, academic work, and editorial duties. He wrote books to promote education, for example he translated into Hungarian a book written by Arnold Cloetta and Wilhelm Filehne in 1881, entitled Lehrbuch der Arzneimittellehre und Arzneiverordnungslehre. This was published in 1894 in Budapest under the title Gyógyszertan tankönyv (Pharmacology Textbook). In 1907 he published his own book Mérgezésekről (On Poisonings), and in 1908 Gyógyszertan orvostanhallgatók és orvosok számára (Pharmacology for medical students and physicians). The latter’s ninth, expanded and revised edition appeared in 1944. Medical students in Hungary and Transylvania learned from this for decades. In 1933 he was appointed chairman of the editorial board of the IV. Magyar Gyógyszerkönyv. His editorial work is also significant. From 1909 to 1944 he was the commissioned editor of the new course of the Magyar Orvosi Archivum (Hungarian Medical Archive), and from 1923 to 1944 he was the editor-in-chief of the Orvosi Hetilap (Medical Weekly). During this time, many of his writings were published here. In December 1927 issue, he announced that certain issues of the Orvosi Hetilap would be supplemented by a permanent supplement entitled Az Orvosi Gyakorlat Kérdései (Questions of Medical Practice). In 1940, in parallel with the Medical Weekly, he founded the monthly Orvostudományi Közlemények (Medical Gazette), which was published until the end of 1944. He strived for the correct use of the Hungarian medical language in all his writings..
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Zoltán Vámossy, versatile and active medical professor of the Institute of Pharmacy

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Introduction: Respiratory complications in the intensive care unit are important because of their frequency and their negative impact on the course of the underlying disease. One of the main risk factors for these complications is mechanical ventilation, which is often applied in critically ill patients. Our aim was to determine the incidence, risk factors and the impact of respiratory complications on the prognosis in the patients admitted to the intensive care unit (ICU).
Material and method: In our retrospective study we included adult patients who spent at least 5 days in the intensive care unit of the Emergency County Hospital Târgu Mureș between 1st of January- 30th of April 2019, we excluded patients who were referred with any respiratory pathology.
Results: Of the 75 patients included 49% developed respiratory complications, 56% of which were pneumonia. We observed an association between the development of complications and smoking (p= 0.0103) and prolonged mechanical ventilation (p= 0.0255). ICU admission was significantly longer in patients with respiratory complications (p=0.0010).
Conclusions: The incidence of pulmonary complications is high among patients referred to intensive care units and has a significant impact on the length of hospital stay.
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Study of pulmonary complications in patients referred to the intensive care unit

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Benzimidazoles, which interfere with the complex life cycle of worms, are essential in the treatment of helminthiasis. Four benzimidazole antihelmintics have been used in human therapy: albendazole, mebendazole, thiabendazole, triclabendazole. The history, representatives, synthesis, physicochemical properties, structure-activity relationships of anthelmintic benzimidazoles are presented in the review, as well as the pharmacological properties and mechanism of action of these agents.
In the last decade, benzimidazole carbamate-structured anthelmintics have also been studied for their antitumor activity.
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Chemical and pharmacological characterization of anthelmintic benzimidazoles

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Between 2012–2018 the University of Medicine and Pharmacy from Tirgu Mureș in partnership with American, Hungarian and Romanian scientists from dozen institutions have launched a research entitled Building Capacity for Tobacco Research in Romania composed of seven complementary research studies. In our paper there are highlighted some timely and specific issues inside the research such as the possibility of computer-based online school prevention, smoking habits of residents and employees of social children’s institutions, the adaptation of a proper legislation and tobacco control, right to clean and smoking-free air. It remains very important the support for tobacco smoke-free, the maintenance of anti-smoking campaigns, the extension of prevention to the juvenile population in order to reduce smoking and the use of alternative tobacco products.
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Tobacco Control: Research, Prevention, Legislation, Human Rights

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Background: The incidence of rectum cancer is rising worldwide. New prognostic factors need to be applied to improve patients’ prognosis. The incidence of sarcopenia has been observed in various malignancies. The quantity of skeletal muscle mass is reflected in the psoas muscle index (PMI), suggesting the presence of sarcopenia. Our aim is to investigate the association of postoperative prognosis of patients with rectum cancer with the occurrence of preoperative sarcopenia with quantitative and qualitative reduction of skeletal muscle mass.
Material and method: We performed a multidisciplinary research and we examined patients diagnosed with rectal cancer. The PMI was determined at the lower edge of the L3 vertebral body, using CT scan. We present our research partial results within three cases.
Results: The PMI of three male patients with rectum cancer who received neoadjuvant chemoradiotherapy was: Case 1 has a PMI of 7.378 cm2/m2, the mean psoas muscle density was 50.14 UH. Case 2 has a PMI of 6,942 cm2/m2 and a mean psoas density of 43.81 UH. Case 3 has a PMI of 8.4885 cm2/m2 and an average density of 43.85 UH in the right and left psoas.
Conclusions: The PMI value can be calculated with simple radiologic measurements, thus determining the diagnosis of sarcopenia. Calculations are performed using standard preoperative CT-scans. A PMI value above the threshold limit is promising in the short term, but in the long term it is not responsible for the deterioration of patients’ general condition and tumor recurrence.
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„George Emil Palade” University of Medicine

Preoperative psoas muscle index a modern prognostic factor in the follow-up of patients with rectal cancer who underwent surgery

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Background: The acute mesenteric ischemia is a rare life-threatening surgical condition, followed by high mortality and morbidity rate. Disparate etiologies and nonspecific symptoms make the diagnosis and the surgery delayed, which leads to a higher mortality rate (60-80%).
Methods: This research was designed as a retrospective study, including a total of 86 patients operated for acute mesenteric ischemia between 2014 and 2020 at the 2nd Department of Surgery in Mureș County Emergency Clinical Hospital. We recorded and analyzed the demographic, clinical, pre-operative radiological and laboratory, and surgical findings of the patients. Results: We analyzed the findings of 86 patients (59,3% men, 40,7% women), the mortality rate was 77,9% (77% in women, 78% in men), and the average age was 76,81 years. The youngest patient was 39 years old and the oldest was 96 in the moment of the diagnosis. The mortality rate was higher (93%) in patients, who suffered just an explorative laparotomy surgery (in 50% of the cases, p=0,001, Chi-squared test). The presence of the peritonitis (12 cases) had a negative impact on the survival rate, every patient who had peritonitis described on the computed tomography died after the surgical intervention (p=0,047, Chi-square test). Statistically, there was not a positive relationship between the time spent in the Emergency Room and the mortality rate, but this time was much longer in the group of patients who died after the surgery, 408,22 minutes, compared to the group of the patients who survived, 352,47 minutes (p=0,431, T-test). The survival rate was higher in patients who had abdominal surgery in the personal history (p=0,021, Chi-square test).
Conclusions: The symptoms and the paraclinical findings of patients with acute mesenteric ischemia are not specific, so the fast radiological examinations and the optimal time for the surgical intervention represent the key of the improvement of the survival rate.
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The analysis of the predictive factors of mortality in patients with acute mesenteric ischemia

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The aim of our research was to prepare polymer-free hydroxypropyl-β-cyclodextrin-(HPβCD) and sulfobutylether-β-cyclodextrin (SBEβCD) based nanofibers. For this purpose, four-four viscous, aqueous solutions were prepared with different concentrations from each cyclodextrin derivative, with the following concentrations: 170, 180, 190 and 200% (v/w) from HPβCD and: 210, 220, 230 and 240% (v/w) from SBEβCD.
The parameters for the electrospinning process were: 1.5 ml/h flowrate, 22-24 G sized needle, and an applied voltage of 25 kV. The distance between the needle and the collector was 13-15 cm in the case of HPβCD, and 9-11 cm in the case of SBEβCD.
The obtained nanofibers were morphologically characterized and their dis-integration process was also tracked. Then, the results obtained were compared within each cyclodextrin group, in order to identify optimal spinning parameters and they were also discussed, based on previous reports.
From our results, we concluded that the 200% HPβCD solution is the most effective for nanofiber formation, producing smooth, homogenous fibers with small diameters, which present ideal disintegration properties. At the tested voltages, it was not possible to form ideal nanofibers from SBEβCD, however, we managed to form some nanofibers with acceptable quality, and the ones made out from the 240% solution of the SBEβCD were the most suitable.
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Department of Pharmaceutical industry and Management

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș

Cyclodextrin-based nanofibers obtained by electrospinning

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Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignant tumor of parafollicular C-cell origin of the thyroid gland, whose tumor cells typically produce calcitonin. The serum level of calcitonin produced by tumor cells is a sensitive tumor marker. An elevated serum level of this and the simultaneous presence of a thyroid nodule confirmed by ultrasound raise a reasonable suspicion of MTC. Still, the first-line MTC confirmation method in diagnosing MTC is fine-needle aspiration cytology (FNA). Objective: The aim of our study was the clinicopathological and cytomorphological analysis of histologically confirmed MTC cases obtained with FNA, as well as their comparison with the clinicopathological and cytomorphological characteristics of papillary thyroid carcinoma (PTC). Material and method: In our retrospective study, we analyzed the FNA cytology findings of patients with nodular goiter examined between 2013-2019 and the available clinical data. Results: In the 7-year period, 1,808 fine-needle aspiration examinations were performed, of which we identified 12 MTC and 77 PTC cases. The average age of patients diagnosed with MTC was 53±13 years. There were nine women and three men in examined cases. The average diameter of the nodules was 14±5 mm. All of our cases were of the sporadic type. The average age of patients diagnosed with MTC was greater than that of patients diagnosed with PTC (53 vs. 44 years, p=0.02367). A female predominance is observed in both diseases, although this is more pronounced in PTC. The diameter of the MTC nodules does not differ significantly from the mean size of the PTC nodules (14 vs. 17 mm, p=0.3138). The cytomorphological characteristics of the MTC cases we examined correspond to those described in the international literature, with minor differences. Conclusions: MTC is one of the rarer thyroid cancers, which is often difficult to distinguish from other types of thyroid cancer based on clinical features alone. Average age at diagnosis is greater than patients with PTC. Accurate diagnosis is critical as it requires a different approach than other types of thyroid cancer, it may require a different surgical approach, and may benefit from targeted therapy. Therefore, knowledge of the cytomorphology of MTC is essential for accurate diagnosis and optimal patient care.
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Department of Pharmacology and Clinical Pharmacy

Emergency County Hospital Târgu Mureș, Pathology Department

Cytomorphological analysis of histologically confirmed cases of medullary thyroid carcinoma

Volume 95 (2022): Issue 1 (July 2022)

Volume 94 (2021): Issue 2 (December 2021)

Volume 94 (2021): Issue 1 (July 2021)

Volume 93 (2020): Issue 2 (December 2020)

Volume 93 (2020): Issue 1 (July 2020)

Volume 92 (2019): Issue 2 (December 2019)

Volume 92 (2019): Issue 1 (July 2019)

Volume 91 (2018): Issue 2 (December 2018)

Volume 91 (2018): Issue 1 (July 2018)

Bulletin of Medical Sciences

 Why subscribe and read One of the few and last medical journal in the region that is published in Hungarian language with a long history looking back into the second half of the 19th century.The journal was established in 1876 with continous appearance until 1962 when due to the establishment of the totalitarian communist regime it was banned.It continuead to publish medical articles after the fall of the communist regime after 1990 and is serving medical professionals ever since.  Why submit Our journal offers fast and accurate peer-review process. Articles ar published in Hungaran language including an English abstract.  Archiving  Sciendo archives the contents of this journal in Portico - digital long-term preservation service of scholarly books, journals and collections.  Plagiarism Policy  The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. 