<abstract xmlns="http://www.w3.org/1999/xhtml">

Vitiligo is a chronic, progressive autoimmune dermatological disease, and stress is known to have an impact on the development of vitiligo. However, the effect of the serotonin pathway and its impact have not been clearly explained for disease progression. Thus, this study aimed to clarify the stress induced serotonin receptor <italic>5-HTR2C</italic> rs6318 variant and its association with vitiligo pathogenesis.
Case-control study was conducted with 108 vitiligo patients and 107 age-sex matched, unrelated healthy control group. Real Time-PCR analysis was used for genotyping the <italic>5-HTR2C</italic> variation. Genotype and allele frequencies, genotype distributions, Hardy-Weinberg Equilibrium (HWE) and vitiligo-related risk measurements were examined. Genotype correlations of the variant were also analyzed based on gender difference, age onset, Koebner phenomenon history, triggered with stress, clinical subgroups, treatment types, the presence of other autoimmune diseases, vitiligo presence in family members and other auto-immune diseases in relatives.
Statistical differences in 5HT-R2C receptor genotypes and allele frequencies between patients and controls were not detected. Genotype frequencies were not in agreement with Hardy-Weinberg Equilibrium in the patients’ group (p&lt;0.00001). The frequency of the risk allele (allele C) was not significantly different between the patient and control groups (p=0.1392). However, in the clinical subgroup analysis, the risk allele presence was detected to be significantly higher for early age onset (&lt;40 years) vitiligo development (p=0.035, OR=Infinity, RR=1.391) and lower in Koebner phenomenon history (p=0.0276, OR= 0.219, RR=0.325).
In conclusion, although there was no association between the <italic>5-HTR2C</italic> variant rs6318 and vitiligo, current results indicate that there is an association between the <italic>5HTR2C</italic> rs6318 variant C allele and early onset vitiligo development.
</abstract>

Bursa Uludag University Institute of Health Science

Department of Dermatology and Venereology

Bursa Uludag University Faculty of Medicine

Footprints of Stress in Vitiligo: Association of the <italic>5-HTR2C</italic> rs6318 Variant

<abstract xmlns="http://www.w3.org/1999/xhtml">

This study aimed to assess the impact of the identified phenolic, flavonoid, and fat-soluble vitamin compounds found in <italic>Caesalpinia coriaria</italic> fruits (EC) aqueous extract on growth performance, helminth parasitic load, feeding behavior, and physiological variables in lambs. The fruits were extracted using water, and three doses of the extract as no extract (EC0 mL/lamb/day), 30 mL of aqueous extract of <italic>Caesalpinia coriaria</italic> fruits (EC30 mL/lamb/day), or 60 mL of aqueous extract of <italic>Caesalpinia coriaria</italic> fruits (EC60 mL/lamb/day) were orally administered to 24 growing crossbred lambs weighing 18-20 kg for 60 days. The HPLC analysis revealed that ferulic acid, ellagic acid, syringic acid, quercetin, and hesperidin were the predominant compounds in <italic>Caesalpinia coriaria</italic> fruits. Additionally, water-soluble vitamin compounds such as thiamine, pantothenic acid, and niacin were detected in the <italic>Caesalpinia coriaria</italic> fruit extract. The dietary administration of EC improved (P &lt; 0.05) average daily gain and feed and water intake. EC30 lambs spent more time (P &lt; 0.03) eating and less time ruminating. The aqueous extract also showed a dose-dependent reduction (P = 0.048) in fecal parasite egg count, with a steady decrease (P = 0.0001) as the extract was applied. EC0 lambs exhibited the highest (P &lt; 0.0001) respiratory frequency and EC30 the lowest. A strong positive correlation was identified between rectal and abdomen temperature in the morning and afternoon measurements. The presence of phenolic and antioxidants in the aqueous extract of C. coriaria, up to 60 mL, demonstrated beneficial effects, including improved productivity, anti-parasitic activity, and mitigation of body temperature. Thus, farmers without access to synthetic drugs can use this plant extract to treat their animals during fattening to reduce gastrointestinal parasites, improve growth rate, and reduce drug residue in animal products. Further studies need to be carried out on the individual components of <italic>Caesalpinia coriaria</italic> fruits to ascertain their effect on body temperature/physiology and to know if the effects are individualistic or synergistic.
</abstract>

Universidad Autónoma del Estado de México

Department of Animal Production and Health

Autonomous Agrarian University Antonio Narro

Forestry and Wood Technology Department, Faculty of Agriculture (EL-Shatby)

Exploring the potential of phenolic and antioxidant compounds identified and quantified of <italic>Caesalpinia coriaria</italic> fruits and their impacts on lambs’ performance and health

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Volume 8 (2024): Issue 2 (April 2024)

Footprints of Stress in Vitiligo: Association of the 5-HTR2C rs6318 Variant

Exploring the potential of phenolic and antioxidant compounds identified and quantified of Caesalpinia coriaria fruits and their impacts on lambs’ performance and health

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