<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>Crohn’s disease (CD) is a chronic, inflammatory bowel disease that can affect any part of the digestive system. The ileocecal region is most commonly involved. Recently, there have been reports about Crohn’s disease isolated to the colon, which may be associated with different clinical behaviour and the need for various treatment options.</p>
</sec>
<sec><h3>Materials/Methods</h3>
<p>The study included 305 patients with CD, 171 women (56%) and 134 men (44%), hospitalized at the Department of Gastroenterology, University Hospital in Lodz. Among them, a group of 101 patients was identified with a lesion location only in the colon (L2) and 204 in the small intestine and colon (L1 and L3). An attempt was made to analyze patients with CD in terms of demographic data, clinical behavior of the disease and location of inflammatory lesions.</p>
</sec>
<sec><h3>Results</h3>
<p>Among the features distinguishing the location of inflammatory lesions isolated to the colon (L2), statistically significantly less frequent occurrence of stenoses (21% at L2 location to 79% at L3, p &lt;0.01) was observed compared to other locations. Moreover, patients with location of L2 lesions required surgery less frequently (27% with L2 vs. 73% L1 with L3, p &lt;0.05). It was also demonstrated that among all the subjects, 42 patients underwent appendectomy before the diagnosis of CD, which constituted 19% of the L2 group patients to 81% of the L1 and L3 group (p &lt;0.05).</p>
</sec>
<sec><h3>Conclusions</h3>
<p>In CD there is a great diversity in the clinical behavior of the disease, which is undoubtedly related to its location. The obtained results indicate that in the group of patients with the location isolated to the colon, stenoses are less common and patients require surgery less frequently.</p>
</sec>
</abstract>

Introduction
Crohn’s disease (CD) is a chronic, inflammatory bowel disease that can affect any part of the digestive system. The ileocecal region is most commonly involved. Recently, there have been reports about Crohn’s disease isolated to the colon, which may be associated with different clinical behaviour and the need for various treatment options.

Materials/Methods
The study included 305 patients with CD, 171 women (56%) and 134 men (44%), hospitalized at the Department of Gastroenterology, University Hospital in Lodz. Among them, a group of 101 patients was identified with a lesion location only in the colon (L2) and 204 in the small intestine and colon (L1 and L3). An attempt was made to analyze patients with CD in terms of demographic data, clinical behavior of the disease and location of inflammatory lesions.

Results
Among the features distinguishing the location of inflammatory lesions isolated to the colon (L2), statistically significantly less frequent occurrence of stenoses (21% at L2 location to 79% at L3, p <0.01) was observed compared to other locations. Moreover, patients with location of L2 lesions required surgery less frequently (27% with L2 vs. 73% L1 with L3, p <0.05). It was also demonstrated that among all the subjects, 42 patients underwent appendectomy before the diagnosis of CD, which constituted 19% of the L2 group patients to 81% of the L1 and L3 group (p <0.05).

Conclusions
In CD there is a great diversity in the clinical behavior of the disease, which is undoubtedly related to its location. The obtained results indicate that in the group of patients with the location isolated to the colon, stenoses are less common and patients require surgery less frequently.

Does the location of inflammatory lesions in the gastrointestinal tract determine the clinical course of Crohn’s disease?

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Czy lokalizacja zmian zapalnych w obrębie przewodu pokarmowego determinuje przebieg kliniczny choroby Leśniowskiego-Crohna?

Introduction
Crohn’s disease (CD) is a chronic, inflammatory bowel disease that can affect any part of the digestive system. The ileocecal region is most...

Parameter	n (%)
Gender (M/F)	134 (44%)/171 (56%)
Age at diagnosis
A1	22 (7%)
A2	194 (63%)
A3	89 (29%)

Lesion location:
L1 – ileal	46 (15%)
L2 – colonic	101 (33%)
L3 – ileocolonic	158 (52%)

Disease behaviour
B1	134 (44%)
B2	81 (27%)
B3	90 (29%)

Extraintestinal symptoms	68 (22%)
Cigarette smoking	91 (30%)
Appendectomy in the history	42 (14%)

Parameter	Location L2N = 101	Location L1 and L3N = 204	p
Gender:			p>0.05
Female	56	115
Male	45	89

Mean age	46 ±16.28	40 ±13.79	p>0.05

Age at diagnosis:			p>0.05
A1 (less than 17 years)	4 (4%)	18 (9%)
A2 (17–40 years)	60 (59%)	134 (65%)
A3 (more than 40 years)	37 (37%)	52 (26%)

Strictures	21%	79%	p<0.01

Abscesses	24%	76%	p>0.05

Fistulas	33%	67%	p>0.05

Surgical procedures	27%	73%	p<0.05

Extraintestinal manifestations	41%	59%	p>0.05

Appendectomy	19%	81%	p<0.05

Biological therapy	33%	67%	p>0.05

Azathioprine	32%	68%	p>0.05

Depressive disorder	33%	67%	p>0.05

Cigarette smoking	27%	73%	p>0.05

Does the location of inflammatory lesions in the gastrointestinal tract determine the clinical course of Crohn’s disease?

Article Category: Original article

Publicado en línea: 18 ene 2021

Páginas: 12 - 17

Recibido: 10 feb 2020

Aceptado: 23 sept 2020

DOI: https://doi.org/10.5604/01.3001.0014.6581

Palabras clave
Crohn’s disease, inflammatory bowel disease

© 2021 Julia Banasik et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Location, behaviour and disease activity in the investigated group

Comparison of demographic and clinical features depending on the location of inflammatory lesions

Does the location of inflammatory lesions in the gastrointestinal tract determine the clinical course of Crohn’s disease?

Article Category: Original article

Publicado en línea: 18 ene 2021

Páginas: 12 - 17

Recibido: 10 feb 2020

Aceptado: 23 sept 2020

DOI: https://doi.org/10.5604/01.3001.0014.6581

Palabras claveCrohn’s disease, inflammatory bowel disease

© 2021 Julia Banasik et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Location, behaviour and disease activity in the investigated group

Comparison of demographic and clinical features depending on the location of inflammatory lesions

Palabras clave
Crohn’s disease, inflammatory bowel disease