<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Calcium phosphate cements (CPC) is a promising materials for bone defect repair. Nanosized apatite or calcium orthophosphate has a better bioactivity than coarser crystals. Chitosan is produced commercially from chitin that is the structural element in the exoskeleton of crustaceans such as crabs and shrimp. The mixing of nanosized apatite and chitosan may provide the consistency cement, improving mechanical properties of the set bone cement.Objective: Develop nanosized apatite powder with chitosan for bone composite cement.Materials and method: Nanosized apatite was synthesized by chemical method at low temperature and used as the single-component for bone cement. The nanosized apatite powder was characterized using X-ray diffraction method, Fourier transform infrared spectroscopy, and transmission electron microscopy. CPCs were developed based on chitosan/nanosized apatite and calcium sulfate hemihydrate. The compressive strength of the set cement was measured after one to four weeks. The phase composition and the morphology of the set cements were investigated.Results: Calcium sulfate hemihydrate was effective in increasing the compressive strength after setting in a simulated body fluid for seven days. The compressive strength of chitosan/nanosized apatite composite was about 18 MPa after soaking.Conclusion: The workability and setting time of this composite were suitable to handling for bone cement. These composite cements had a significant clinical advantage for substitution of the regenerated bone.</abstract>

Background: Calcium phosphate cements (CPC) is a promising materials for bone defect repair. Nanosized apatite or calcium orthophosphate has a better bioactivity than coarser crystals. Chitosan is produced commercially from chitin that is the structural element in the exoskeleton of crustaceans such as crabs and shrimp. The mixing of nanosized apatite and chitosan may provide the consistency cement, improving mechanical properties of the set bone cement.Objective: Develop nanosized apatite powder with chitosan for bone composite cement.Materials and method: Nanosized apatite was synthesized by chemical method at low temperature and used as the single-component for bone cement. The nanosized apatite powder was characterized using X-ray diffraction method, Fourier transform infrared spectroscopy, and transmission electron microscopy. CPCs were developed based on chitosan/nanosized apatite and calcium sulfate hemihydrate. The compressive strength of the set cement was measured after one to four weeks. The phase composition and the morphology of the set cements were investigated.Results: Calcium sulfate hemihydrate was effective in increasing the compressive strength after setting in a simulated body fluid for seven days. The compressive strength of chitosan/nanosized apatite composite was about 18 MPa after soaking.Conclusion: The workability and setting time of this composite were suitable to handling for bone cement. These composite cements had a significant clinical advantage for substitution of the regenerated bone.

Original article. Development of chitosan/nanosized apatite composites for bone cements

Institute of Engineering, Suranaree University of Technology, Muang, Nakhon Ratchasima 30000,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: Calcium phosphate cements (CPC) is a promising materials for bone defect repair. Nanosized apatite or calcium orthophosphate has a better...

Original article. Development of chitosan/nanosized apatite composites for bone cements

Publicado en línea: 04 feb 2017

Páginas: 499 - 506

DOI: https://doi.org/10.5372/1905-7415.0504.065

Palabras clave
Apatite, bone cements, calcium phosphate cement, chitosan, composites, nanosized apatite

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Original article. Development of chitosan/nanosized apatite composites for bone cements

Publicado en línea: 04 feb 2017

Páginas: 499 - 506

DOI: https://doi.org/10.5372/1905-7415.0504.065

Palabras claveApatite, bone cements, calcium phosphate cement, chitosan, composites, nanosized apatite

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
Apatite, bone cements, calcium phosphate cement, chitosan, composites, nanosized apatite