Cardiac Implication in Pediatric Multisystemic Inflammatory Syndrome – Three Case Reports and Review of the Literature

1 Morphology TC. Available from: https://www.uptodate.com/contents/covid-19-multisystem-inflammatory-syndrome-in-children-mis-c-clinical-features-evaluation-and-diagnosis?search=pmis&source=search_result&selectedTitle=2~94&usage_type=default&display_rank=2#H1873038899 Morphology TC Available from: https://www.uptodate.com/contents/covid-19-multisystem-inflammatory-syndrome-in-children-mis-c-clinical-features-evaluation-and-diagnosis?search=pmis&source=search_result&selectedTitle=2~94&usage_type=default&display_rank=2#H1873038899 Search in Google Scholar

2 Sendzikaite S, Heying R, Milanesi O, Hanseus K, Michel-Behnke I. COVID-19 FAQs in paediatric and congenital cardiology: AEPC position paper. Cardiology Young. 2021;31(3):344–51. SendzikaiteS HeyingR MilanesiO HanseusK Michel-BehnkeI COVID-19 FAQs in paediatric and congenital cardiology: AEPC position paper Cardiology Young 2021 31 3 344 51 10.1017/S1047951120005028790066433407975 Search in Google Scholar

3 Niño-Taravilla C, Otaola-Arca H, Lara-Aguilera N, Zuleta-Morales Y, Ortiz-Fritz P. Multisystem inflammatory syndrome in children, Chile, may–august 2020. Emerging Infectious Disease. 2021 May 1;27(5):1457–61. Niño-TaravillaC Otaola-ArcaH Lara-AguileraN Zuleta-MoralesY Ortiz-FritzP Multisystem inflammatory syndrome in children, Chile, may–august 2020 Emerging Infectious Disease 2021 May 1 27 5 1457 61 10.3201/eid2705.204591808447833760725 Search in Google Scholar

4 Ramcharan T, Nolan O et al. Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital. Pediatric Cardiology. 2020;41(7):1391–401. RamcharanT NolanO Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital Pediatric Cardiology 2020 41 7 1391 401 10.1007/s00246-020-02391-2728963832529358 Search in Google Scholar

5 Niño-Taravilla C, et al. Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 treated with tocilizumab. Pediatric Reports. 2020;12(3):142–8. Niño-TaravillaC Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 treated with tocilizumab Pediatric Reports 2020 12 3 142 8 10.3390/pediatric12030029776846933291619 Search in Google Scholar

6 Biscetti F, Rando MM, Nardella E, Cecchini AL, Bruno P, Landolfi R, et al. Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury. International Journal of Molecular Sciences. 2020;21(21):1–14. BiscettiF RandoMM NardellaE CecchiniAL BrunoP LandolfiR Cardiovascular disease and SARS-CoV-2: The role of host immune response versus direct viral injury International Journal of Molecular Sciences 2020 21 21 1 14 10.3390/ijms21218141766357933143371 Search in Google Scholar

7 Benn CS, et al. A small jab – a big effect: nonspecific immunomodulation by vaccines. Trends in Immunology. 2013 Sep 1;34(9):431–9. BennCS A small jab – a big effect: nonspecific immunomodulation by vaccines Trends in Immunology 2013 Sep 1 34 9 431 9 10.1016/j.it.2013.04.00423680130 Search in Google Scholar

8 Zimmermann P, Curtis N. Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. The Pediatric Infectious Disease Journal [Internet]. 2020 [cited 2021 Oct 16];39(5):355. Available from: /pmc/articles/PMC7158880/ ZimmermannP CurtisN Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children The Pediatric Infectious Disease Journal [Internet] 2020 [cited 2021 Oct 16] 39 5 355 Available from: /pmc/articles/PMC7158880/ 10.1097/INF.0000000000002660715888032310621 Search in Google Scholar

9 Nathan N, et al. The Wide Spectrum of COVID-19 Clinical Presentation in Children. Journal of Clinical Medicine 2020, Vol 9, Page 2950 [Internet]. 2020 Sep 12; 9(9):2950. Available from: https://www.mdpi.com/2077-0383/9/9/2950/html NathanN The Wide Spectrum of COVID-19 Clinical Presentation in Childr Journal of Clinical Medicine 2020 9 2950 [Internet]. 2020 Sep 12; 9(9):2950. Available from: https://www.mdpi.com/2077-0383/9/9/2950/html 10.3390/jcm9092950756466532932612 Search in Google Scholar

10 Rodriguez-Gonzalez M, et al. Cardiovascular impact of COVID-19 with a focus on children: A systematic review. Vol. 8, World Journal of Clinical Cases. 2020. 5250–5283p. Rodriguez-GonzalezM Cardiovascular impact of COVID-19 with a focus on children: A systematic review 8 World Journal of Clinical Cases 2020 5250 5283 10.12998/wjcc.v8.i21.5250767471433269260 Search in Google Scholar

11 Elias MD, McCrindle BW, Larios G, Choueiter NF, Dahdah N, Harahsheh AS, et al. Management of Multisystem Inflammatory Syndrome in Children Associated With COVID-19: A Survey From the International Kawasaki Disease Registry. CJC Open [Internet]. 2020 Nov 1;2(6):632–40. EliasMD McCrindleBW LariosG ChoueiterNF DahdahN HarahshehAS Management of Multisystem Inflammatory Syndrome in Children Associated With COVID-19: A Survey From the International Kawasaki Disease Registry CJC Open [Internet] 2020 Nov 1 2 6 632 40 10.1016/j.cjco.2020.09.004748469332935083 Search in Google Scholar

12 Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395(10237):1607–1608. RiphagenS GomezX Gonzalez-MartinezC WilkinsonN TheocharisP Hyperinflammatory shock in children during COVID-19 pandemic Lancet 2020 395 10237 1607 1608 10.1016/S0140-6736(20)31094-1 Search in Google Scholar

13 Belhadjer Z, Méot M, Bajolle F, Khraiche D, Legendre A, Abakka S, et al. Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic. Circulation. 2020;142(5):429–36. BelhadjerZ MéotM BajolleF KhraicheD LegendreA AbakkaS Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic Circulation 2020 142 5 429 36 10.1161/CIRCULATIONAHA.120.04836032418446 Search in Google Scholar

14 Whittaker E, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 [published online June 8, 2020]. JAMA. https://doi.org/10.1001/jama.2020.10369 WhittakerE Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 [published online June 8, 2020] JAMA https://doi.org/10.1001/jama.2020.10369 10.1001/jama.2020.10369728135632511692 Search in Google Scholar

15 Kaushik S, Aydin SI, Derespina KR, Bansal PB, Kowalsky S, Trachtman R, et al. Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City. The Journal of Pediatrics [Internet]. 2020;224:24–9. Available from: https://doi.org/10.1016/j.jpeds.2020.06.045 KaushikS AydinSI DerespinaKR BansalPB KowalskyS TrachtmanR Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City The Journal of Pediatrics [Internet] 2020 224 24 9 Available from: https://doi.org/10.1016/j.jpeds.2020.06.045 10.1016/j.jpeds.2020.06.045729376032553861 Search in Google Scholar

16 Feldstein LR, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. https://doi.org/101056/NEJMoa2021680 [Internet]. 2020 Jun 29; 383(4):334–46. Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa2021680 FeldsteinLR Multisystem Inflammatory Syndrome in U.S. Children and Adolescents https://doi.org/101056/NEJMoa2021680 [Internet]. 2020 Jun 29 383 4 334 46 Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa2021680 Search in Google Scholar

17 Alsaied T, Tremoulet AH et al. Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children Running title: The Multisystem Inflammatory Syndrome in Children. Circulation. 2020;143:78–88. AlsaiedT TremouletAH Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children Running title: The Multisystem Inflammatory Syndrome in Children Circulation 2020 143 78 88 10.1161/CIRCULATIONAHA.120.04983633166178 Search in Google Scholar

18 Wang, J. G., Zhong et al. Coronavirus Disease 2019-Related Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis. Biochemistry Research International, 2021. https://doi.org/10.1155/2021/5596727 WangJ. G. Zhong Coronavirus Disease 2019-Related Multisystem Inflammatory Syndrome in Children: A Systematic Review and Meta-Analysis Biochemistry Research International 2021 https://doi.org/10.1155/2021/5596727 10.1155/2021/5596727832436134336288 Search in Google Scholar

19 Kanegaye JT, Wilder MS, Molkara D, et al. Recognition of a Kawasaki disease shock syndrome. Pediatrics. 2009;123(5):e783–e789. doi:10.1542/peds.2008-1871 KanegayeJT WilderMS MolkaraD Recognition of a Kawasaki disease shock syndrome Pediatrics 2009 123 5 e783 e789 10.1542/peds.2008-1871 284847619403470 Open DOISearch in Google Scholar