Anti-inflammatory Effect of Gambier Catechin (Uncaria gambir Roxb) on Rheumatoid Arthritis: A Review

1 Hák T, Janoušková S, Moldan B. Sustainable development goals: A need for relevant indicators. Ecol Indic. 2016;60:565-73. Search in Google Scholar

2 World Health Organization. Noncommunicable Diseases. World Health Organization; 2021. Available from: https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases [Last accessed on 2022 Mar 25]. Search in Google Scholar

3 Grabowski D, Aagaard-Hansen J, Willaing I, Jensen BB. Global Action Plan for the Prevention and Control of non Communicable Diseases. Vol. 1. Geneva: WHO Press, World Health Organization; 2013. Search in Google Scholar

4 England BR, Roul P, Yang Y, Kalil AC, Michaud K, Thiele GM, et al. Risk of COVID-19 in rheumatoid arthritis: A national veterans affairs matched cohort study in at-risk individuals. Arthritis Rheumatol. 2021;73(12):2179-88. https://doi.org/10.1002/art.41800 PMid:33955209 Search in Google Scholar

5 Almutairi KB, Nossent JC, Preen DB, Keen HI, Inderjeeth CA. The prevalence of rheumatoid arthritis: A systematic review of population-based studies. Ann Rheum Dis. 2020;79(Suppl 1):1246-73. Search in Google Scholar

6 Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018;6:15. https://doi.org/10.1038/s41413-018-0016-9 PMid:29736302 Search in Google Scholar

7 Bykerk VP, Akhavan P, Hazlewood GS, Schieir O, Dooley A, Haraoui B, et al. Canadian rheumatology association recommendations for pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs. J Rheumatol. 2012;39(8):1559-82. https://doi.org/10.3899/jrheum.110207 PMid:21921096 Search in Google Scholar

8 Cho SK, Kim D, Won S, Lee J, Choi CB, Choe JY, et al. Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis. Korean J Intern Med. 2019;34(4):910-6. https://doi.org/10.3904/kjim.2017.113 PMid:29232938 Search in Google Scholar

9 Bakker MF, Jacobs JW, Welsing PM, Verstappen SM, Tekstra J, Ton E, et al. Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: A randomized trial. Ann Intern Med. 2012;156(5):329-39. https://doi.org/10.7326/0003-4819-156-5-201203060-00004 PMid:22393128 Search in Google Scholar

10 Heimans L, Wevers-de Boer KV, Visser K, Goekoop RJ, van Oosterhout M, Harbers JB, et al. A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: The IMPROVED study. Ann Rheum Dis. 2014;73(7):1356-61. https://doi.org/10.1136/annrheumdis-2013-203243 PMid:23716067 Search in Google Scholar

11 Tobing IS, Sukara E. Biodiversity based industry, the future of Indonesia. Vis Vitalis. 2008;1(2):1-12. Search in Google Scholar

12 Hosen N, Pengkajian B, Pertanian T, Barat BS. Gambir Agricultural Business System Profile in West Sumatra. J Penelit Pertan Terap. 2017;17(2):124-31. https://doi.org/10.25181/jppt.v17i2.291 Search in Google Scholar

13 Haryanto S. Encyclopedia of Indonesian Medicinal Plants. Vol. 2. Yogyakarta: Pallmall; 2009. Search in Google Scholar

14 Karatas A, Dagli AF, Orhan C, Gencoglu H, Ozgen M, Sahin N, et al. Epigallocatechin 3-gallate attenuates arthritis by regulating Nrf2, HO-1, and cytokine levels in an experimental arthritis model. Biotechnol Appl Biochem. 2020;67(3):317-22. https://doi.org/10.1002/bab.1860 PMid:31746064 Search in Google Scholar

15 Aditya M, Ariyanti PR. Benefits of gambir (Uncaria gambir Roxb) as an antioxidant. J Kedok Univ Lampung Majority. 2016;5(3):129-33. Search in Google Scholar

16 Abner EL, Schmitt FA, Mendiondo MS, Marcum JL, Kryscio RJ. Vitamin E and All-cause mortality: A meta-analysis. Curr Aging Sci. 2012;4(2):158-70. https://doi.org/10.2174/1874609811104020158 PMid:21235492 Search in Google Scholar

17 Yunarto N, Intan PR, Kurniatri AA, Sulistyowati I, Aini N. Anti-inflammatory activities of ethyl acetate fraction from Uncaria gambir leaves through the inhibition of edema, COX-2 and iNOS Expression. 2020;22(Ishr 2019):108-12. Search in Google Scholar

18 Fan FY, Sang LX, Jiang M. Catechins and their therapeutic benefits to inflammatory bowel disease. Molecules. 2017;22(3):484. https://doi.org/10.3390/molecules22030484 PMid:28335502 Search in Google Scholar

19 Nakanishi T, Mukai K, Yumoto H, Hirao K, Hosokawa Y, Matsuo T. Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors. Eur J Oral Sci. 2010;118(2):145-50. http://doi.org/10.1111/j.1600-0722.2010.00714.x PMid:20487003 Search in Google Scholar

20 Dinarello CA, van der Meer JW. Treating inflammation by blocking interleukin-1 in humans. Semin Immunol. 2013;25(6):469-84. https://doi.org/10.1016/j.smim.2013.10.008 PMid:24275598 Search in Google Scholar

21 Singh AK, Umar S, Riegsecker S, Chourasia M, Ahmed S, Egcg B. Regulation of transforming growth factor β-Activated kinase activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts: Suppression of K63-Linked autoubiquitination of tumor necrosis factor receptor-associated factor 6. Arthritis Rheumatol. 2016;68(2):347-58. Search in Google Scholar

22 Zheng Y, Xiao L, Yu C, Jin P, Qin D, Xu Y, et al. Enhanced antiarthritic efficacy by nanoparticles of (-)-epigallocatechin gallateglucosamine-Casein. J Agric Food Chem. 2019;67(23):6476-86. https://doi.org/10.1021/acs.jafc.9b02075 PMid:31117504 Search in Google Scholar

23 Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, et al. TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun. 2018;9(1):1994. https://doi.org/10.1038/s41467-018-04460-w PMid:29777109 Search in Google Scholar

24 Xu YR, Lei CQ. TAK1-TABs complex: A central signalosome in inflammatory responses. Front Immunol. 2021;11:608976. https://doi.org/10.3389/fimmu.2020.608976 PMid:33469458 Search in Google Scholar

25 Fechtner S, Singh A, Chourasia M, Ahmed S. Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts. Toxicol Appl Pharmacol. 2017;329:112-20. https://doi.org/10.1016/j.taap.2017.05.016 PMid:28532672 Search in Google Scholar

26 Lee F, Bae KH, Ng S, Yamashita A, Kurisawa M. Hyaluronic acid-green tea catechin conjugates as a potential therapeutic agent for rheumatoid arthritis. RSC Adv. 2021;11(24):14285-94. https://doi.org/10.1039/d1ra01491a PMid:35423998 Search in Google Scholar

27 Liu W, Fan JB, Xu DW, Zhang J, Cui ZM. Epigallocatechin-3-gallate protects against tumor necrosis factor alpha induced inhibition of osteogenesis of mesenchymal stem cells. Exp Biol Med (Maywood). 2016;241(6):658-66. https://doi.org/10.1177/1535370215624020 PMid:26748399 Search in Google Scholar

28 Chen CH, Ho ML, Chang JK, Hung SH, Wang GJ. Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line. Osteoporos Int. 2005;16(12):2039-45. https://doi.org/10.1007/s00198-005-1995-0 PMid:16170444 Search in Google Scholar

29 Pitrityah P. Activity Test of Gambier Catechin Isolate (Uncaria gambir Roxb) Against Carrageenan-Induced Sparague-Dawley Strain Male White Rat Leg Edema. Fakultas Kedokteran dan Ilmu Kesehatan Program Studi Farmasi. Vol. 1. Jakarta: Universitas Islam Negeri; 2016. Available from: https://repository.uinjkt.ac.id/dspace/handle/123456789/34197 [Last accessed on 2023 Feb 22]. Search in Google Scholar

30 Mateen S, Moin S, Khan AQ, Zafar A, Fatima N. Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS One. 2016;11(4):e0152925. https://doi.org/10.1371/journal.pone.0152925 PMid:27043143 Search in Google Scholar

31 Mat Saad MF, Goh HH, Rajikan R, Tuan Yusof TR, Baharum SN, Bunawan H. Uncaria gambir (W. Hunter) Roxb: From phytochemical composition to pharmacological importance. Trop J Pharm Res. 2020;19(8):1767-73. Search in Google Scholar

32 Maleki SJ, Crespo JF, Cabanillas B. Anti-inflammatory effects of flavonoids. Food Chem. 2019;299:125124. https://doi.org/10.1016/j.foodchem.2019.125124 PMid:31288163 Search in Google Scholar

33 de Almeida Gonçalves G, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, et al. Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis. Food Funct. 2015;6(8):2701-11. https://doi.org/10.1039/c5fo00548e PMid:26146010 Search in Google Scholar