Evaluation of Plasma Levels of Interferon-Gamma, Interleukin-6, and Transforming Growth Factor-Beta in Under-Five Children with Malaria Parasitaemia

1 World Health Organization. World Malaria Report 2022. Geneva: World Health Organization; 2022. Available from: https://www.who.int/teams/global-malaria-program [Last accessed on 2023 Jan 25]. Search in Google Scholar

2 Lalremruata A, Jeyaraj S, Engleitner T, Joanny F, Lang A, Belard S, et al. Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing. Malar J. 2017;16(1):398. https://doi.org/10.1186/s12936-017-2044-0 PMid:28974215 Search in Google Scholar

3 World Health Organization. Guidelines for Malaria. Geneva: World Health Organization; 2022. Available from: https://apps.who.int/iris/handle/10665/351995 [Last accessed on 2023 Jan 25]. Search in Google Scholar

4 Awosolu OB, Yahaya ZS, Haziqah MT, Simon-Oke IA, Fakunle C. A cross-sectional study of the prevalence, density, and risk factors associated with malaria transmission in urban communities of Ibadan, Southwestern Nigeria. Heliyon. 2021;7(1):e05975. https://doi.org/10.1016/j.heliyon.2021.e05975 PMid:33521357 Search in Google Scholar

5 White M, Watson J. Age, exposure and immunity. Elife. 2018;7:e40150. https://doi.org/10.7554/elife.40150 PMid:30129437 Search in Google Scholar

6 Sato S. Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology. J Physiol Anthropol. 2021;40(1):1. https://doi.org/10.1186/s40101-020-00251-9 PMid:33413683 Search in Google Scholar

7 Sebina I, Fogg LG, James KR, Soon MS, Akter J, Thomas BS, et al. IL-6 promotes CD4⁺ T-cell and B-cell activation during Plasmodium infection. Parasite Immunol. 2017;39(10):e12455. https://doi.org/10.1111/pim.12455 PMid:28748530 Search in Google Scholar

8 Kurup SP, Butler NS, Harty JT. T cell-mediated immunity to malaria. Nat Rev Immunol. 2019;19(7):457-71. https://doi.org/10.1038/s41577-019-0158-z PMid:30940932 Search in Google Scholar

9 Mohamedahmed KA, Abakar AD, Ahmed MO, Muktar MM, Nour BY. The role of TNF-α level as predictive diagnostic biomarker among children with severe falciparum malaria in endemic area in Sudan. Int J Acad Health Med Res. 2019;3(7):1-6. Search in Google Scholar

10 Ortega-Pajares A, Rogerson SJ. The rough guide to monocytes in malaria infection. Front Immunol. 2018;9:2888. https://doi.org/10.3389/fimmu.2018.02888 PMid:30581439 Search in Google Scholar

11 Kany S, Vollrath JT, Relja B. Cytokines in inflammatory disease. Int J Mol Sci. 2019;20(23):6008. https://doi.org/10.3390/ijms20236008 PMid:31795299 Search in Google Scholar

12 Frimpong A, Amponsah J, Adjokatseh AS, Agyemang D, Bentum-Ennin L, Ofori EA, et al. Asymptomatic malaria infection is maintained by a balanced pro-and anti-inflammatory response. Front Microbiol. 2020;11:559255. https://doi.org/10.3389/fmicb.2020.559255 PMid:33281757 Search in Google Scholar

13 Ann A. Nutrition, food security and health. In: Kliegman R, editor. Nelson Textbook of Pediatrics. 20^th ed. Philadelphia, PA: Elsevier Inc.; 2015. p. 295-306. Search in Google Scholar

14 Oyegue-Liabagui SL, Bouopda-Tuedom AG, Kouna CL, Maghendji-Nzondo S, Nzoughe H, Tchitoula-Makaya N, et al. Pro-and anti-inflammatory cytokines in children with malaria in Franceville, Gabon. Am J Clin Exp Immunol. 2017;6(2):9-20. https://doi.org/10.1051/parasite/2016032 PMid:28337387 Search in Google Scholar

15 Farrington L, Vance H, Rek J, Prahl M, Jagannathan P, Katureebe A, et al. Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children. Malar J. 2017;16(1):499. https://doi.org/10.1186/s12936-017-2148-6 PMid:29284469 Search in Google Scholar

16 Hanisch BR, Bangirana P, Opoka RO, Park GS, John CC. Thrombocytopenia may mediate disease severity in Plasmodium falciparum malaria through reduced transforming growth factor beta-1 regulation of proinflammatory and anti-inflammatory cytokines. Pediatr Infect Dis J. 2015;34(7):783-8. https://doi.org/10.1097/INF.0000000000000729 PMid:25886788 Search in Google Scholar

17 Kotepui KU, Kwankae w P, Masangkay FR, Mahittikorn A, Kotepui M. Transforming growth factor-β concerning malarial infection and severity: A systematic review and meta-analysis. Trop Med Infect Dis. 2022;7(10):299. https://doi.org/10.3390/tropicalmed7100299 PMid:36288040 Search in Google Scholar

18 Kurup SP, Obeng-Adjei N, Anthony SM, Traore B, Doumbo OK, Crompton PD, et al. Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Nat Med. 2017;23(10):1220-5. https://doi.org/10.1038/nm.4395 PMid:28892065 Search in Google Scholar