<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>BACKGROUND</h3>
<p>Malignant melanoma (MM) is the deadliest form of skin cancer and the most common carcinoma to metastasize into the gastrointestinal tract (GI). While the jejunum, ileum, colon, and rectum are common gastrointestinal sites of metastasis, metastatic melanoma in the stomach is rare and usually not detected until late in the disease.</p>
</sec>
<sec><h3>CASE PRESENTATION</h3>
<p>We report a patient who presented with hematemesis, epigastric pain, and weight loss. In the second esophagogastroduodenoscopy, after 8 months from the first endoscopic assessment, a double ulcerative gastric mass was found, and histopathology confirmed metastatic malignant melanoma. The complete surgical resection of GI metastatic MM in carefully selected patients not only provides symptom control but has also been associated with an increase in overall survival in the absence of other metastatic sites. At present, the overall survival of patients with advanced metastatic MM who have been treated with a combination of immunotherapeutic agents reaches 52% at 5 years.</p>
</sec>
<sec><h3>CONCLUSION</h3>
<p>The role of surgery for patients with metastatic involvement of the GI tract with MM is evolving in the era of effective systemic treatments.</p>
</sec>
</abstract>

BACKGROUND
Malignant melanoma (MM) is the deadliest form of skin cancer and the most common carcinoma to metastasize into the gastrointestinal tract (GI). While the jejunum, ileum, colon, and rectum are common gastrointestinal sites of metastasis, metastatic melanoma in the stomach is rare and usually not detected until late in the disease.

CASE PRESENTATION
We report a patient who presented with hematemesis, epigastric pain, and weight loss. In the second esophagogastroduodenoscopy, after 8 months from the first endoscopic assessment, a double ulcerative gastric mass was found, and histopathology confirmed metastatic malignant melanoma. The complete surgical resection of GI metastatic MM in carefully selected patients not only provides symptom control but has also been associated with an increase in overall survival in the absence of other metastatic sites. At present, the overall survival of patients with advanced metastatic MM who have been treated with a combination of immunotherapeutic agents reaches 52% at 5 years.

CONCLUSION
The role of surgery for patients with metastatic involvement of the GI tract with MM is evolving in the era of effective systemic treatments.

A Rare Case of Gastric Metastasis from a Rare Case of Mucosal Malignant Melanoma

Clinic of Surgery, University Clinical Center of Kosova

University of Prishtina ‘Hasan Prishtina’

Open Access Macedonian Journal of Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

{"article-title":"A Rare Case of Gastric Metastasis from a Rare Case of Mucosal Malignant Melanoma"}

BACKGROUND
Malignant melanoma (MM) is the deadliest form of skin cancer and the most common carcinoma to metastasize into the gastrointestinal tract (GI)....

A Rare Case of Gastric Metastasis from a Rare Case of Mucosal Malignant Melanoma

Publicado en línea: 28 jun 2024

Páginas: 362 - 364

Recibido: 22 abr 2024

Aceptado: 23 may 2024

DOI: https://doi.org/10.3889/oamjms.2024.11917

Palabras clave
Metastatic malignant melanoma, Gastrointestinal bleeding, Histopathology

© 2024 Zaim Gashi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

A Rare Case of Gastric Metastasis from a Rare Case of Mucosal Malignant Melanoma

Publicado en línea: 28 jun 2024

Páginas: 362 - 364

Recibido: 22 abr 2024

Aceptado: 23 may 2024

DOI: https://doi.org/10.3889/oamjms.2024.11917

Palabras claveMetastatic malignant melanoma, Gastrointestinal bleeding, Histopathology

© 2024 Zaim Gashi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.

Palabras clave
Metastatic malignant melanoma, Gastrointestinal bleeding, Histopathology