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Determinants of Childhood Asthma: A Case Control Study from a Tertiary Care Hospital in Bengaluru, South India


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j.jmotherandchild.20232701.d-22-00059.tab.005

Andrea Daniella Johnson Alex Fernando Maria Lewin Farah Naaz Fathima
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Environment and housing factors in childhood asthma N=60.

Variable Category Cases (30)N (%) Controls (30)N (%) Odds Ratio(95% CI) P-value
Residence Rural 12 (40.0) 19 (63.3) 0.87 (0.31–2.46) 0.79
Urban 18 (60.0) 11 (36.7)
Located in industrial area Yes 13 (13.3) 1 (3.3) 22.18 (2.66–184.79) 0.001
No 17 (86.7) 29 (96.7)
Location of house Main road 15 (50.0) 8 (26.7) 2.75 (0.93–8.1) 0.06
Away from main road 15 (50.0) 22 (73.3)
Overcrowding Yes 16 (53.3) 12 (40.0) 1.71 (0.62–4.77) 0.30
No 14 (46.7) 18 (60.0)
Exposure to tobacco smoke Yes 6 (20.0) 5 (16.7) 1.25 (0.34–4.64) 0.74
No 24 (80.0) 25 (83.3)
Exposure to firewood Yes 3 (10.0) 6 (20.0) 0.44 (0.1–1.97) 0.28
No 27 (90.0) 24 (80.0)
Exposure to incense Yes 17 (56.7) 7 (23.3) 4.3 (1.41–13.07) 0.01
No 13 (43.3) 23 (76.7)
Exposure to mosquito repellants Yes 15 (50.0) 8 (26.7) 2.75 (0.93–8.1) 0.06
No 15 (50.0) 22 (73.3)
Kerosene for cooking Yes 6 (20.0) 7 (23.3) 0.82 (0.24–2.81) 0.75
No 24 (80.0) 23 (76.7)
Pets in the house Yes 12 (40.0) 7 (23.3) 2.19 (0.72–6.7) 0.17
No 18 (60.0) 23 (76.7)
Synthetic material of child's pillow cover Yes 4 (13.3) 8 (26.7) 0.42 (0.11–1.6) 0.2
No 26 (86.7) 22 (73.3)
Regular washing child's bedlinen Yes 27 (90.0) 24 (80.0) 2.25 (0.51–9.99) 0.28
No 3 (10.0) 6 (20.0)
Child plays with soft toys Yes 15 (50.0) 11 (36.7) 1.73 (0.62–4.84) 0.32
No 15 (50.0) 19 (63.3)
Cockroach infestation at home Yes 22 (73.3) 17 (56.7) 2.1 (0.71–6.22) 0.18
No 8 (26.7) 13 (43.3)
Heavy carpet/curtain/rugs at home Yes 15 (50) 6 (20) 4.00 (1.27–12.58) 0.02
No 15 (50) 24 (80)

Pre-natal, genetic and birth factors in childhood asthma N=60.

Variable Category Cases (30)N (%) Controls (30)N (%) Odds Ratio(95% CI) P-value
Parity index of mother Primipara 9 (30.0) 9 (30.0) 1.0 (0.33–3.01) 0.99
Multipara 21 (70.0) 21 (70.0)
Birth order 1 16 (53.3) 21 (70.0) 0.49 (0.17–1.41) 0.18
≥2 14 (46.7) 9 (30.0)
Parental history of allergy / atopy Yes 14 (46.7) 0 (0) 3.98 (1.10–6.86) 0.007*
No 16 (53.3) 30 (100)
Gestational age at birth Preterm 5 (16.7) 7 (23.3) 0.66 (0.18–2.36) 0.52
Full term 25 (83.3) 23 (76.7)
Mode of delivery Vaginal (normal/assisted) 19 (63.3) 23 (76.7) 0.53 (0.17–1.62) 0.26
Caesarean section 11 (36.7) 7 (23.3)
Birth weight < 2500 g 4 (13.3) 8 (26.7) 0.42 (0.11–1.59) 0.17
≥ 2500 g 26 (86.7) 22 (73.3)

Sociodemographic factors in childhood asthma N=60.

Variable Category Cases (30)N (%) Controls (30)N (%) Odds Ratio(95% CI) P-value
Age Under 5 17 (56.7) 16 (53.3) 1.14 (0.41–3.16) 0.79
Above 5yrs 13 (43.3) 14 (46.7)
Gender Male 18 (60.0) 18 (60.0) 1.00 (0.36–2.81) 0.99
Female 12 (40.0) 12 (40.0)
Maternal education Up to High school 20 (66.7) 25 (83.3) 0.4 (0.19–1.36) 0.14
Graduate/Postgraduate 10 (33.3) 5 (16.7)
Socioeconomic status Upper/upper-middle 18 (60.0) 13 (43.3) 1.96 (0.70–5.48) 0.19
Middle/Lower-middle/lower 12 (40.0) 17 (56.7)

Risk factors for childhood asthma in neonatal period, infancy and childhood N=60.

Variable Category Cases (30)N (%) Controls (30)N (%) Odds Ratio(95% CI) P-value
Received pre-lacteal feeds Yes 13 (43.3) 11 (36.7) 1.32 (0.47–3.72) 0.60
No 17 (56.7) 19 (63.3)
Exclusive breastfeeding for 6 months Yes 17 (56.7) 24 (80.0) 0.33 (0.1–1.03) 0.052
No 13 (43.3) 6 (20.0)
Experienced respiratory problems in the neonatal period Yes 12 (40.0) 3 (10.0) 6.00 (1.48–24.3) 0.01
No 18 (60.0) 27 (90.0)
NICU admission Yes 11(36.7) 6 (20.0) 2.32 (0.72–7.41) 0.15
No 19(63.3) 24 (80.0)
Any illness in the first year Yes 24 (80.0) 12 (40.0) 6.00 (1.89–19.04) 0.002
No 6 (20.0) 18 (60.0)
Child experiences symptoms of allergic rhinitis Yes 23(76.7) 2 (6.7) 46 (8.7–243.25) <0.001
No 7 (23.3) 28 (93.3)
History of atopy/allergy Yes 6 (20.0) 0 (0) 2.78 (0.14–5.71) 0.06*
No 24 (80.0) 30 (100)
Nutritional status (present) Overweight 5 (16.7) 9 (30.0) - -
Normal 22 (73.3) 20 (66.7) 0.33 (0.03–3.21) 0.34
Underweight 3 (10.0) 2 (3.3) 0.91 (0.49–1.67) 0.76
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