Molecular Epidemiology of mcr-1-Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
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Al Mana H, Johar AA, Kassem II, Eltai NO. Transmissibility and persistence of the plasmid-borne mobile colistin resistance gene, mcr-1, harbored in poultry-associated E. coli. Antibiotics. 2022 Jun; 11(6):774. https://doi.org/10.3390/antibiotics11060774
Al ManaHJoharAAKassemIIEltaiNO.Transmissibility and persistence of the plasmid-borne mobile colistin resistance gene, mcr-1, harbored in poultry-associated E. coli.Antibiotics.2022Jun;11(6):774.https://doi.org/10.3390/antibiotics11060774
Alikhan NF, Petty NK, Ben Zakour NL, Beatson SA. BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics. 2011 Aug;12:402. https://doi.org/10.1186/1471-2164-12-402
AlikhanNFPettyNKBen ZakourNLBeatsonSA.BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons.BMC Genomics.2011Aug;12:402.https://doi.org/10.1186/1471-2164-12-402
Arafi V, Hasani A, Sadeghi J, Varshochi M, Poortahmasebi V, Hasani A, Hasani R. Uropathogenic Escherichia coli endeavors: An insight into the characteristic features, resistance mechanism, and treatment choice. Arch Microbiol. 2023 May;205(6):226. https://doi.org/10.1007/s00203-023-03553-5
ArafiVHasaniASadeghiJVarshochiMPoortahmasebiVHasaniAHasaniR.Uropathogenic Escherichia coli endeavors: An insight into the characteristic features, resistance mechanism, and treatment choice.Arch Microbiol.2023May;205(6):226.https://doi.org/10.1007/s00203-023-03553-5
Bastidas-Caldes C, Cisneros-Vásquez E, Zambrano A, Mosquera-Maza A, Calero-Cáceres W, Rey J, Yamamoto Y, Yamamoto M, Calvopiña M, de Waard JH. Co-harboring of beta-lactamases and mcr-1 genes in Escherichia coli and Klebsiella pneumoniae from healthy carriers and backyard animals in rural communities in Ecuador. Antibiotics. 2023 May;12(5):856. https://doi.org/10.3390/antibiotics12050856
Bastidas-CaldesCCisneros-VásquezEZambranoAMosquera-MazaACalero-CáceresWReyJYamamotoYYamamotoMCalvopiñaMde WaardJH.Co-harboring of beta-lactamases and mcr-1 genes in Escherichia coli and Klebsiella pneumoniae from healthy carriers and backyard animals in rural communities in Ecuador.Antibiotics.2023May;12(5):856.https://doi.org/10.3390/antibiotics12050856
Berglund B, Chen B, Tärnberg M, Sun Q, Xu L, Welander J, Li Y, Bi Z, Nilsson M, Nilsson LE. Characterization of extended-spectrum β-lactamase-producing Escherichia coli harboring mcr-1 and toxin genes from human fecal samples from China. Future Microbiol. 2018 Nov;13:1647–1655. https://doi.org/10.2217/fmb-2018-0242
BerglundBChenBTärnbergMSunQXuLWelanderJLiYBiZNilssonMNilssonLE.Characterization of extended-spectrum β-lactamase-producing Escherichia coli harboring mcr-1 and toxin genes from human fecal samples from China.Future Microbiol.2018Nov;13:1647–1655.https://doi.org/10.2217/fmb-2018-0242
Bi Z, Berglund B, Sun Q, Nilsson M, Chen B, Tärnberg M, Ding L, Stålsby Lundborg C, Bi Z, et al. Prevalence of the mcr-1 colistin resistance gene in extended-spectrum ß-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China. Int J Antimicrob Agents. 2017 Apr;49(4):493–497. https://doi.org/10.1016/j.ijantimicag.2016.12.018
BiZBerglundBSunQNilssonMChenBTärnbergMDingLStålsby LundborgCBiZPrevalence of the mcr-1 colistin resistance gene in extended-spectrum ß-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China.Int J Antimicrob Agents.2017Apr;49(4):493–497.https://doi.org/10.1016/j.ijantimicag.2016.12.018
Binsker U, Käsbohrer A, Hammerl JA. Global colistin use: A review of the emergence of resistant Enterobacterales and the impact on their genetic basis. FEMS Microbiol Rev. 2022 Feb;46(1):fuab049. https://doi.org/10.1093/femsre/fuab049
BinskerUKäsbohrerAHammerlJA.Global colistin use: A review of the emergence of resistant Enterobacterales and the impact on their genetic basis.FEMS Microbiol Rev.2022Feb;46(1):fuab049.https://doi.org/10.1093/femsre/fuab049
Cao XL, Shen H, Xu YY, Xu XJ, Zhang ZF, Cheng L, Chen JH, Arakawa Y. High prevalence of fosfomycin resistance gene fosA3 in blactx-m-harbouring Escherichia coli from urine in a Chinese tertiary hospital during 2010–2014. Epidemiol Infect. 2017 Mar; 145(4):818–824. https://doi.org/10.1017/s0950268816002879
CaoXLShenHXuYYXuXJZhangZFChengLChenJHArakawaY.High prevalence of fosfomycin resistance gene fosA3 in blactx-m-harbouring Escherichia coli from urine in a Chinese tertiary hospital during 2010–2014.Epidemiol Infect.2017Mar;145(4):818–824.https://doi.org/10.1017/s0950268816002879
Carattoli A, Zankari E, García-Fernández A, Voldby Larsen M, Lund O, Villa L, Møller Aarestrup F, Hasman H. In silico detection and typing of plasmids using Plasmid Finder and plasmid multilocus sequence typing. Antimicrob Agents Chemother. 2014 Jul;58(7):3895–3903. https://doi.org/10.1128/aac.02412-14
CarattoliAZankariEGarcía-FernándezAVoldby LarsenMLundOVillaLMøller AarestrupFHasmanH.In silico detection and typing of plasmids using Plasmid Finder and plasmid multilocus sequence typing.Antimicrob Agents Chemother.2014Jul;58(7):3895–3903.https://doi.org/10.1128/aac.02412-14
Chan WS, Au CH, Ho DN, Chan TL, Ma ES, Tang BS. Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong. BMC Infect Dis. 2018 Feb;18(1):81. https://doi.org/10.1186/s12879-018-2987-y
ChanWSAuCHHoDNChanTLMaESTangBS.Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong.BMC Infect Dis.2018Feb;18(1):81.https://doi.org/10.1186/s12879-018-2987-y
Chen J, Wang D, Ding Y, Zhang L, Li X. Molecular epidemiology of plasmid-mediated fosfomycin resistance gene determinants in Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae isolates in China. Microb Drug Resist. 2019 Mar;25(2):251–257. https://doi.org/10.1089/mdr.2018.0137
ChenJWangDDingYZhangLLiX.Molecular epidemiology of plasmid-mediated fosfomycin resistance gene determinants in Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae isolates in China.Microb Drug Resist.2019Mar;25(2):251–257.https://doi.org/10.1089/mdr.2018.0137
Chen R, Wang G, Wang Q, Zhang M, Wang Y, Wan Z, Si Z, Bai Y, Song Z, Lu X, et al. Antimicrobial resistance and molecular epidemiology of carbapenem-resistant Escherichia coli from urinary tract infections in Shandong, China. Int Microbiol. 2023 Nov;26(4):1157–1166. https://doi.org/10.1007/s10123-023-00369-7
ChenRWangGWangQZhangMWangYWanZSiZBaiYSongZLuXAntimicrobial resistance and molecular epidemiology of carbapenem-resistant Escherichia coli from urinary tract infections in Shandong, China.Int Microbiol.2023Nov;26(4):1157–1166.https://doi.org/10.1007/s10123-023-00369-7
Chotinantakul K, Chusri P, Okada S. Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand. PeerJ. 2022 Nov;10:e14408. https://doi.org/10.7717/peerj.14408
ChotinantakulKChusriPOkadaS.Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.PeerJ.2022Nov;10:e14408.https://doi.org/10.7717/peerj.14408
CLSI. Performance standards for antimicrobial susceptibility testing. 33th ed. CLSI supplement M100. Wayne (USA): Clinical and Laboratory Standards Institute; 2023.CLSI.Performance standards for antimicrobial susceptibility testing.33th ed.CLSI supplement M100.Wayne (USA):Clinical and Laboratory Standards Institute;2023.Search in Google Scholar
Dadashi M, Sameni F, Bostanshirin N, Yaslianifard S, Khosravi-Dehaghi N, Nasiri MJ, Goudarzi M, Hashemi A, Hajikhani B. Global prevalence and molecular epidemiology of mcr-mediated colistin resistance in Escherichia coli clinical isolates: A systematic review. J Glob Antimicrob Resist. 2022 Jun;29:444–461. https://doi.org/10.1016/j.jgar.2021.10.022
DadashiMSameniFBostanshirinNYaslianifardSKhosravi-DehaghiNNasiriMJGoudarziMHashemiAHajikhaniB.Global prevalence and molecular epidemiology of mcr-mediated colistin resistance in Escherichia coli clinical isolates: A systematic review.J Glob Antimicrob Resist.2022Jun;29:444–461.https://doi.org/10.1016/j.jgar.2021.10.022
De La Cadena E, Mahecha M, Velandia AM, García-Betancur JC, Rojas LJ, Porras J, Pallares C, Villegas MV. Identification of mcr-1 genes and characterization of resistance mechanisms to colistin in Escherichia coli isolates from Colombian hospitals. Antibiotics. 2023 Mar;12(3):488. https://doi.org/10.3390/antibiotics12030488
De La CadenaEMahechaMVelandiaAMGarcía-BetancurJCRojasLJPorrasJPallaresCVillegasMV.Identification of mcr-1 genes and characterization of resistance mechanisms to colistin in Escherichia coli isolates from Colombian hospitals.Antibiotics.2023Mar;12(3):488.https://doi.org/10.3390/antibiotics12030488
Di Francesco A, Salvatore D, Sakhria S, Bertelloni F, Catelli E, Ben Yahia S, Tlatli A. Colistin resistance genes in broiler chickens in Tunisia. Animals. 2023 Apr;13(8):1409. https://doi.org/10.3390/ani13081409
Di FrancescoASalvatoreDSakhriaSBertelloniFCatelliEBen YahiaSTlatliA.Colistin resistance genes in broiler chickens in Tunisia.Animals.2023Apr;13(8):1409.https://doi.org/10.3390/ani13081409
Ding Y, Saw WY, Tan LWL, Moong DKN, Nagarajan N, Teo YY, Seedorf H. Extended-spectrum β-lactamase-producing and mcr-1-positive Escherichia coli from the gut microbiota of healthy Singaporeans. Appl Environ Microbiol. 2021 Sep;87(20):e0048821. https://doi.org/10.1128/aem.00488-21
DingYSawWYTanLWLMoongDKNNagarajanNTeoYYSeedorfH.Extended-spectrum β-lactamase-producing and mcr-1-positive Escherichia coli from the gut microbiota of healthy Singaporeans.Appl Environ Microbiol.2021Sep;87(20):e0048821.https://doi.org/10.1128/aem.00488-21
Dong A, Liu C, Hua X, Yu Y, Guo Y, Wang D, Liu X, Chen H, Wang H, Zhu L. Bioinformatic analysis of structures and encoding genes of Escherichia coli surface polysaccharides sheds light on the heterologous biosynthesis of glycans. BMC Genomics. 2023 Apr; 24(1):168. https://doi.org/10.1186/s12864-023-09269-6
DongALiuCHuaXYuYGuoYWangDLiuXChenHWangHZhuL.Bioinformatic analysis of structures and encoding genes of Escherichia coli surface polysaccharides sheds light on the heterologous biosynthesis of glycans.BMC Genomics.2023Apr;24(1):168.https://doi.org/10.1186/s12864-023-09269-6
Fan R, Li C, Duan R, Qin S, Liang J, Xiao M, Lv D, Jing H, Wang X. Retrospective screening and analysis of mcr-1 and blandm in Gramnegative bacteria in China, 2010–2019. Front Microbiol. 2020 Feb; 11:121. https://doi.org/10.3389/fmicb.2020.00121
FanRLiCDuanRQinSLiangJXiaoMLvDJingHWangX.Retrospective screening and analysis of mcr-1 and blandm in Gramnegative bacteria in China, 2010–2019.Front Microbiol.2020Feb;11:121.https://doi.org/10.3389/fmicb.2020.00121
Han H, Liu W, Cui X, Cheng X, Jiang X. Co-existence of mcr-1 and blandm-5 in an Escherichia coli strain isolated from the pharmaceutical industry, WWTP. Infect Drug Resist. 2020 Mar;13:851–854. https://doi.org/10.2147/idr.S245047
HanHLiuWCuiXChengXJiangX.Co-existence of mcr-1 and blaNDM-5 in an Escherichia coli strain isolated from the pharmaceutical industry, WWTP.Infect Drug Resist.2020Mar;13:851–854.https://doi.org/10.2147/idr.S245047
He K, Li W, Zhao B, Xu H, Pan Y, He D, Hu G, Wu H, Yuan L. Spreading advantages of coresident plasmids blactx-m-bearing IncFII and mcr-1-bearing IncI2 in Escherichia coli. Microbiol Spectr. 2022 Feb;10(1):e0170621. https://doi.org/10.1128/spectrum.01706-21
HeKLiWZhaoBXuHPanYHeDHuGWuHYuanL.Spreading advantages of coresident plasmids blactx-m-bearing IncFII and mcr-1-bearing IncI2 in Escherichia coli.Microbiol Spectr.2022Feb;10(1):e0170621.https://doi.org/10.1128/spectrum.01706-21
Heras J, Domínguez C, Mata E, Pascual V, Lozano C, Torres C, Zarazaga M. GelJ--a tool for analyzing DNA fingerprint gel images. BMC Bioinformatics. 2015 Aug;16:270. https://doi.org/10.1186/s12859-015-0703-0
HerasJDomínguezCMataEPascualVLozanoCTorresCZarazagaM.GelJ--a tool for analyzing DNA fingerprint gel images.BMC Bioinformatics.2015Aug;16:270.https://doi.org/10.1186/s12859-015-0703-0
Huang S, Wang S, Li Y, Fang M, Kou Z, Chen B, Xu L, Bi Z, Xu H, Chi X, et al. Prevalence and transmission of mobilized colistin resistance (mcr-1) gene positive Escherichia coli in healthy rural residents in Shandong province, China. Microbiol Res. 2021 Dec; 253: 126881. https://doi.org/10.1016/j.micres.2021.126881
HuangSWangSLiYFangMKouZChenBXuLBiZXuHChiXPrevalence and transmission of mobilized colistin resistance (mcr-1) gene positive Escherichia coli in healthy rural residents in Shandong province, China.Microbiol Res.2021Dec;253:126881.https://doi.org/10.1016/j.micres.2021.126881
Ibrahim DR, Dodd CER, Stekel DJ, Meshioye RT, Diggle M, Lister M, Hobman JL. Multidrug-resistant ESBL-producing E. coli in clinical samples from the UK. Antibiotics. 2023 Jan;12(1):169. https://doi.org/10.3390/antibiotics12010169
IbrahimDRDoddCERStekelDJMeshioyeRTDiggleMListerMHobmanJL.Multidrug-resistant ESBL-producing E. coli in clinical samples from the UK.Antibiotics.2023Jan;12(1):169.https://doi.org/10.3390/antibiotics12010169
Jamil A, Zahoor MA, Nawaz Z, Siddique AB, Khurshid M. Genetic diversity of Escherichia coli coharboring mcr-1 and extended spectrum beta-lactamases from poultry. Biomed Res Int. 2022 Oct; 2022:8224883. https://doi.org/10.1155/2022/8224883
JamilAZahoorMANawazZSiddiqueABKhurshidM.Genetic diversity of Escherichia coli coharboring mcr-1 and extended spectrum beta-lactamases from poultry.Biomed Res Int.2022Oct;2022:8224883.https://doi.org/10.1155/2022/8224883
Karki D, Dhungel B, Bhandari S, Kunwar A, Joshi PR, Shrestha B, Rijal KR, Ghimire P, Banjara MR. Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples. Gut Pathog. 2021 Jul;13(1):45. https://doi.org/10.1186/s13099-021-00441-5
KarkiDDhungelBBhandariSKunwarAJoshiPRShresthaBRijalKRGhimirePBanjaraMR.Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples.Gut Pathog.2021Jul;13(1):45.https://doi.org/10.1186/s13099-021-00441-5
Lee SY, Park YJ, Yu JK, Jung S, Kim Y, Jeong SH, Arakawa Y. Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3. J Antimicrob Chemother. 2012 Dec;67(12):2843–2847. https://doi.org/10.1093/jac/dks319
LeeSYParkYJYuJKJungSKimYJeongSHArakawaY.Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3.J Antimicrob Chemother.2012Dec;67(12):2843–2847.https://doi.org/10.1093/jac/dks319
Letunic I, Bork P. Interactive Tree of Life (iTOL) v6: Recent updates to the phylogenetic tree display and annotation tool. Nucleic Acids Res. 2024 Jul;52(Wl):W78–W82. https://doi.org/10.1093/nar/gkae268
LetunicIBorkP.Interactive Tree of Life (iTOL) v6: Recent updates to the phylogenetic tree display and annotation tool.Nucleic Acids Res.2024Jul;52(Wl):W78–W82.https://doi.org/10.1093/nar/gkae268
Li Q, Qian C, Zhang X, Zhu T, Shi W, Gao M, Feng C, Xu M, Lin H, Lin L, et al. Colistin resistance and molecular characterization of the genomes of mcr-1-positive Escherichia coli clinical isolates. Front Cell Infect Microbiol. 2022 May;12:854534. https://doi.org/10.3389/fcimb.2022.854534
LiQQianCZhangXZhuTShiWGaoMFengCXuMLinHLinLColistin resistance and molecular characterization of the genomes of mcr-1-positive Escherichia coli clinical isolates.Front Cell Infect Microbiol.2022May;12:854534.https://doi.org/10.3389/fcimb.2022.854534
Li W, He Z, Di W, Xu W, Li Y, Sun B. Transposition mechanism of ISApl1-the determinant of colistin resistance dissemination. Anti-microb Agents Chemother. 2024a Mar;68(3):e0123123. https://doi.org/10.1128/aac.01231-23
LiWHeZDiWXuWLiYSunB.Transposition mechanism of ISApl1-the determinant of colistin resistance dissemination.Anti-microb Agents Chemother.2024aMar;68(3):e0123123.https://doi.org/10.1128/aac.01231-23
Li Y, Sun X, Dong N, Wang Z, Li R. Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–2023. Drug Resist Updat. 2024b Jan;72:101031. https://doi.org/10.1016/j.drup.2023.101031
LiYSunXDongNWangZLiR.Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005–2023.Drug Resist Updat.2024bJan;72:101031.https://doi.org/10.1016/j.drup.2023.101031
Lima T, Loureiro D, Henriques A, Ramos F, Pomba C, Domingues S, da Silva GJ. Occurrence and biological cost of mcr-1-carrying plasmids co-harbouring beta-lactamase resistance genes in zoonotic pathogens from intensive animal production. Antibiotics. 2022 Oct; 11(10):1356. https://doi.org/10.3390/antibiotics11101356
LimaTLoureiroDHenriquesARamosFPombaCDominguesSda SilvaGJ.Occurrence and biological cost of mcr-1-carrying plasmids co-harbouring beta-lactamase resistance genes in zoonotic pathogens from intensive animal production.Antibiotics.2022Oct;11(10):1356.https://doi.org/10.3390/antibiotics11101356
Ling Z, Yin W, Shen Z, Wang Y, Shen J, Walsh TR. Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9. J Antimicrob Chemother. 2020 Nov;75(11):3087–3095. https://doi.org/10.1093/jac/dkaa205
LingZYinWShenZWangYShenJWalshTR.Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9.J Antimicrob Chemother.2020Nov;75(11):3087–3095.https://doi.org/10.1093/jac/dkaa205
Liu X, Li X, Yang AW, Tang B, Jian ZJ, Zhong YM, Li HL, Li YM, Yan Q, Liang XH et al. Community fecal carriage and molecular epidemiology of extended-spectrum β-lactamase-and carbapene-mase-producing Escherichia coli from healthy children in the Central South China. Infect Drug Resist. 2022 Apr;15:1601–1611. https://doi.org/10.2147/idr.S357090
LiuXLiXYangAWTangBJianZJZhongYMLiHLLiYMYanQLiangXHCommunity fecal carriage and molecular epidemiology of extended-spectrum β-lactamase-and carbapene-mase-producing Escherichia coli from healthy children in the Central South China.Infect Drug Resist.2022Apr;15:1601–1611.https://doi.org/10.2147/idr.S357090
Liu X, Wang Y, Cui L, Li Y, Xue F, Liu J, Wang L, Shen Y, Lv Y. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016. J Antimicrob Chemother. 2018 Jul;73(7):1786–1790. https://doi.org/10.1093/jac/dky092
LiuXWangYCuiLLiYXueFLiuJWangLShenYLvY.A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016.J Antimicrob Chemother.2018Jul;73(7):1786–1790.https://doi.org/10.1093/jac/dky092
Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study. Lancet Infect Dis. 2016 Feb;16(2):161–168. https://doi.org/10.1016/s1473-3099(15)00424-7
LiuYYWangYWalshTRYiLXZhangRSpencerJDoiYTianGDongBHuangXEmergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study.Lancet Infect Dis.2016Feb;16(2):161–168.https://doi.org/10.1016/s1473-3099(15)00424-7
Loras C, Mendes AC, Peixe L, Novais Â, Alós JI. Escherichia coli resistant to fosfomycin from urinary tract infections: Detection of the fosA3 gene in Spain. J Glob Antimicrob Resist. 2020 Jun;21:414–416. https://doi.org/10.1016/j.jgar.2020.01.023
LorasCMendesACPeixeLNovaisÂAlósJI.Escherichia coli resistant to fosfomycin from urinary tract infections: Detection of the fosA3 gene in Spain.J Glob Antimicrob Resist.2020Jun;21:414–416.https://doi.org/10.1016/j.jgar.2020.01.023
Lu X, Zeng M, Xu J, Zhou H, Gu B, Li Z, Jin H, Wang X, Zhang W, Hu Y, et al. Epidemiologic and genomic insights on mcr-1-harbour-ing Salmonella from diarrhoeal outpatients in Shanghai, China, 2006–2016. EBioMedicine. 2019 Apr;42:133–144. https://doi.org/10.1016/j.ebiom.2019.03.006
LuXZengMXuJZhouHGuBLiZJinHWangXZhangWHuYEpidemiologic and genomic insights on mcr-1-harbour-ing Salmonella from diarrhoeal outpatients in Shanghai, China, 2006–2016.EBioMedicine.2019Apr;42:133–144.https://doi.org/10.1016/j.ebiom.2019.03.006
Ma J, Wang J, Feng J, Liu Y, Yang B, Li R, Bai L, He T, Wang X, Yang Z. Characterization of three porcine Acinetobacter towneri strains coharboring tet(X3) and blaoxa-58. Front Cell Infect Microbiol. 2020 Dec;10:586507. https://doi.org/10.3389/fcimb.2020.586507
MaJWangJFengJLiuYYangBLiRBaiLHeTWangXYangZ.Characterization of three porcine Acinetobacter towneri strains coharboring tet(X3) and blaoxa-58.Front Cell Infect Microbiol.2020Dec;10:586507.https://doi.org/10.3389/fcimb.2020.586507
Nang SC, Li M, Harper M, Mandela E, Bergen PJ, Rolain JM, Zhu Y, Velkov T, Li J. Polymyxin causes cell envelope remodelling and stress responses in mcr-1-harbouring Escherichia coli. Int J Antimicrob Agents. 2022 Feb;59(2):106505. https://doi.org/10.1016/j.ijantimicag.2021.106505
NangSCLiMHarperMMandelaEBergenPJRolainJMZhuYVelkovTLiJ.Polymyxin causes cell envelope remodelling and stress responses in mcr-1-harbouring Escherichia coli.Int J Antimicrob Agents.2022Feb;59(2):106505.https://doi.org/10.1016/j.ijantimicag.2021.106505
Onduru OG, Mkakosya RS, Aboud S, Rumisha SF. Genetic determinants of resistance among ESBL-producing Enterobacteriaceae in Community and Hospital Settings in East, Central, and Southern Africa: A systematic review and meta-analysis of prevalence. Can J Infect Dis Med Microbiol. 2021 Jun;2021:5153237. https://doi.org/10.1155/2021/5153237
OnduruOGMkakosyaRSAboudSRumishaSF.Genetic determinants of resistance among ESBL-producing Enterobacteriaceae in Community and Hospital Settings in East, Central, and Southern Africa: A systematic review and meta-analysis of prevalence.Can J Infect Dis Med Microbiol.2021Jun;2021:5153237.https://doi.org/10.1155/2021/5153237
Prjibelski A, Antipov D, Meleshko D, Lapidus A, Korobeynikov A. Using SPAdes De Novo Assembler. Curr Protoc Bioinformatics. 2020 Jun;70(1):e102. https://doi.org/10.1002/cpbi.102
PrjibelskiAAntipovDMeleshkoDLapidusAKorobeynikovA.Using SPAdes De Novo Assembler.Curr Protoc Bioinformatics.2020Jun;70(1):e102.https://doi.org/10.1002/cpbi.102
Protonotariou E, Meletis G, Malousi A, Kotzamanidis C, Tychala A, Mantzana P, Theodoridou K, Ioannidou M, Hatzipantelis E, Tsakris A, et al. First detection of mcr-1-producing Escherichia coli in Greece. J Glob Antimicrob Resist. 2022 Dec;31:252–255. https://doi.org/10.1016/j.jgar.2022.10.008
ProtonotariouEMeletisGMalousiAKotzamanidisCTychalaAMantzanaPTheodoridouKIoannidouMHatzipantelisETsakrisAFirst detection of mcr-1-producing Escherichia coli in Greece.J Glob Antimicrob Resist.2022Dec;31:252–255.https://doi.org/10.1016/j.jgar.2022.10.008
Rhouma M, Madec JY, Laxminarayan R. Colistin: From the shadows to a One Health approach for addressing antimicrobial resistance. Int J Antimicrob Agents. 2023 Feb;61(2):106713. https://doi.org/10.1016/j.ijantimicag.2023.106713
RhoumaMMadecJYLaxminarayanR.Colistin: From the shadows to a One Health approach for addressing antimicrobial resistance.Int J Antimicrob Agents.2023Feb;61(2):106713.https://doi.org/10.1016/j.ijantimicag.2023.106713
Robin F, Beyrouthy R, Colot J, Saint-Sardos P, Berger-Carbonne A, Dalmasso G, Delmas J, Bonnet R. MCR-1 in ESBL-producing Escherichia coli responsible for human infections in New Caledonia. J Antimicrob Chemother. 2017 Mar;72(3):946–947. https://doi.org/10.1093/jac/dkw508
RobinFBeyrouthyRColotJSaint-SardosPBerger-CarbonneADalmassoGDelmasJBonnetR.MCR-1 in ESBL-producing Escherichia coli responsible for human infections in New Caledonia.J Antimicrob Chemother.2017Mar;72(3):946–947.https://doi.org/10.1093/jac/dkw508
Rodríguez-Santiago J, Cornejo-Juárez P, Silva-Sánchez J, Garza-Ramos U. Polymyxin resistance in Enterobacterales: Overview and epidemiology in the Americas. Int J Antimicrob Agents. 2021 Nov; 58(5):106426. https://doi.org/10.1016/j.ijantimicag.2021.106426
Rodríguez-SantiagoJCornejo-JuárezPSilva-SánchezJGarza-RamosU.Polymyxin resistance in Enterobacterales: Overview and epidemiology in the Americas.Int J Antimicrob Agents.2021Nov;58(5):106426.https://doi.org/10.1016/j.ijantimicag.2021.106426
Rodríguez-Santiago J, Rodríguez-Medina N, Tamayo-Legorreta EM, Silva-Sánchez J, Téllez-Sosa J, Duran-Bedolla J, Aguilar-Vera A, Lecona-Valera AN, Garza-Ramos U, Alpuche-Aranda C. Molecular and genomic insights of mcr-1-producing Escherichia coli isolates from piglets. Antibiotics. 2022 Jan;11(2):157. https://doi.org/10.3390/antibiotics11020157
Rodríguez-SantiagoJRodríguez-MedinaNTamayo-LegorretaEMSilva-SánchezJTéllez-SosaJDuran-BedollaJAguilar-VeraALecona-ValeraANGarza-RamosUAlpuche-ArandaC.Molecular and genomic insights of mcr-1-producing Escherichia coli isolates from piglets.Antibiotics.2022Jan;11(2):157.https://doi.org/10.3390/antibiotics11020157
Shafiq M, Rahman SU, Bilal H, Ullah A, Noman SM, Zeng M, Yuan Y, Xie Q, Li X, Jiao X. Incidence and molecular characterization of ESBL-producing and colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan. J Appl Microbiol. 2022 Sep;133(3):1169–1182. https://doi.org/10.1111/jam.15469
ShafiqMRahmanSUBilalHUllahANomanSMZengMYuanYXieQLiXJiaoX.Incidence and molecular characterization of ESBL-producing and colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan.J Appl Microbiol.2022Sep;133(3):1169–1182.https://doi.org/10.1111/jam.15469
Shen Y, Wu Z, Wang Y, Zhang R, Zhou HW, Wang S, Lei L, Li M, Cai J, Tyrrell J, et al. Heterogeneous and flexible transmission of mcr-1 in hospital-associated Escherichia coli. mBio. 2018 Jul; 9(4): e00943-18. https://doi.org/10.1128/mBio.00943-18
ShenYWuZWangYZhangRZhouHWWangSLeiLLiMCaiJTyrrellJHeterogeneous and flexible transmission of mcr-1 in hospital-associated Escherichia coli.mBio.2018Jul;9(4):e00943-18.https://doi.org/10.1128/mBio.00943-18
Shi J, Zhu H, Liu C, Xie H, Li C, Cao X, Shen H. Epidemiological and genomic characteristics of global mcr-positive Escherichia coli isolates. Front Microbiol. 2023 Jan;13:1105401. https://doi.org/10.3389/fmicb.2022.1105401
ShiJZhuHLiuCXieHLiCCaoXShenH.Epidemiological and genomic characteristics of global mcr-positive Escherichia coli isolates.Front Microbiol.2023Jan;13:1105401.https://doi.org/10.3389/fmicb.2022.1105401
Siguier P, Perochon J, Lestrade L, Mahillon J, Chandler M. IS finder: The reference centre for bacterial insertion sequences. Nucleic Acids Res. 2006 Jan;34(Suppl_1):D32-D36. https://doi.org/10.1093/nar/gkj014
SiguierPPerochonJLestradeLMahillonJChandlerM.IS finder: The reference centre for bacterial insertion sequences.Nucleic Acids Res.2006Jan;34(Suppl_1):D32–D36.https://doi.org/10.1093/nar/gkj014
Stamatakis A. RAxML version 8: A tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics. 2014 May; 30(9):1312–1313. https://doi.org/10.1093/bioinformatics/btu033
StamatakisA.RAxML version 8: A tool for phylogenetic analysis and post-analysis of large phylogenies.Bioinformatics.2014May;30(9):1312–1313.https://doi.org/10.1093/bioinformatics/btu033
Szmolka A, Gellért Á, Szemerits D, Rapcsák F, Spisák S, Adorján A. Emergence and genomic features of a mcr-1 Escherichia coli from duck in Hungary. Antibiotics. 2023 Oct;12(10):1519. https://doi.org/10.3390/antibiotics12101519
SzmolkaAGellértÁSzemeritsDRapcsákFSpisákSAdorjánA.Emergence and genomic features of a mcr-1 Escherichia coli from duck in Hungary.Antibiotics.2023Oct;12(10):1519.https://doi.org/10.3390/antibiotics12101519
Tang B, Chang J, Chen Y, Lin J, Xiao X, Xia X, Lin J, Yang H, Zhao G. Escherichia fergusonii, an underrated repository for antimicrobial resistance in food animals. Microbiol Spectr. 2022 Feb; 10(1):e0161721. https://doi.org/10.1128/spectrum.01617-21
TangBChangJChenYLinJXiaoXXiaXLinJYangHZhaoG.Escherichia fergusonii, an underrated repository for antimicrobial resistance in food animals.Microbiol Spectr.2022Feb;10(1):e0161721.https://doi.org/10.1128/spectrum.01617-21
Tegetmeyer HE, Jones SC, Langford PR, Baltes N. ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76. Vet Microbiol. 2008 Apr;128(3–4):342–353. https://doi.org/10.1016/j.vetmic.2007.10.025
TegetmeyerHEJonesSCLangfordPRBaltesN.ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76.Vet Microbiol.2008Apr;128(3–4):342–353.https://doi.org/10.1016/j.vetmic.2007.10.025
Tian X, Fang R, Wu Q, Zheng X, Zhao Y, Dong G, Wang C, Zhou T, Cao J. Emergence of a multidrug-resistant ST 27 Escherichia coli co-harboring blandm-1, mcr-1, and fosA3 from a patient in China. J Antibiot (Tokyo). 2020 Sep;73(9):636–641. https://doi.org/10.1038/s41429-020-0306-5
TianXFangRWuQZhengXZhaoYDongGWangCZhouTCaoJ.Emergence of a multidrug-resistant ST 27 Escherichia coli co-harboring blandm-1, mcr-1, and fosA3 from a patient in China.J Antibiot (Tokyo).2020Sep;73(9):636–641.https://doi.org/10.1038/s41429-020-0306-5
Vu Thi Ngoc B, Le Viet T, Nguyen Thi Tuyet M, Nguyen Thi Hong T, Nguyen Thi Ngoc D, Le Van D, Chu Thi L, Tran Huy H, Penders J, Wertheim H et al. Characterization of genetic elements carrying mcr-1 gene in Escherichia coli from the community and hospital settings in Vietnam. Microbiol Spectr. 2022 Feb;10(1):e0135621. https://doi.org/10.1128/spectrum.01356-21
Vu Thi NgocBLe VietTNguyen Thi TuyetMNguyen Thi HongTNguyen Thi NgocDLe VanDChu ThiLTran HuyHPendersJWertheimHCharacterization of genetic elements carrying mcr-1 gene in Escherichia coli from the community and hospital settings in Vietnam.Microbiol Spectr.2022Feb;10(1):e0135621.https://doi.org/10.1128/spectrum.01356-21
Wang Y, Xu C, Zhang R, Chen Y, Shen Y, Hu F, Liu D, Lu J, Guo Y, Xia X et al. Changes in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: An epidemiological comparative study. Lancet Infect Dis. 2020 Oct;20(10):1161–1171. https://doi.org/10.1016/s1473-3099(20)30149-3
WangYXuCZhangRChenYShenYHuFLiuDLuJGuoYXiaXChanges in colistin resistance and mcr-1 abundance in Escherichia coli of animal and human origins following the ban of colistin-positive additives in China: An epidemiological comparative study.Lancet Infect Dis.2020Oct;20(10):1161–1171.https://doi.org/10.1016/s1473-3099(20)30149-3
Xie J, Liang B, Xu X, Yang L, Li H, Li P, Qiu S, Song H. Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China. J Glob Antimicrob Resist. 2022 Jun;29:88-96. https://doi.org/10.1016/j.jgar.2022.02.008
XieJLiangBXuXYangLLiHLiPQiuSSongH.Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China.J Glob Antimicrob Resist.2022Jun;29:88–96.https://doi.org/10.1016/j.jgar.2022.02.008
Yin Y, Qiu L, Wang G, Guo Z, Wang Z, Qiu J, Li R. Emergence and transmission of plasmid-mediated mobile colistin resistance gene mcr-10 in humans and companion animals. Microbiol Spectr. 2022 Oct;10(5):e0209722. https://doi.org/10.1128/spectrum.02097-22
YinYQiuLWangGGuoZWangZQiuJLiR.Emergence and transmission of plasmid-mediated mobile colistin resistance gene mcr-10 in humans and companion animals.Microbiol Spectr.2022Oct;10(5):e0209722.https://doi.org/10.1128/spectrum.02097-22
Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, Aarestrup FM, Larsen MV. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012 Nov; 67(11):2640–2644. https://doi.org/10.1093/jac/dks261
ZankariEHasmanHCosentinoSVestergaardMRasmussenSLundOAarestrupFMLarsenMV.Identification of acquired antimicrobial resistance genes.J Antimicrob Chemother.2012Nov;67(11):2640–2644.https://doi.org/10.1093/jac/dks261
Zhang P, Wang J, Wang X, Bai X, Ma J, Dang R, Xiong Y, Fanning S, Bai L, Yang Z. Characterization of five Escherichia coli isolates coexpressing ESBL and mcr-1 resistance mechanisms from different origins in China. Front Microbiol. 2019 Aug;10:1994. https://doi.org/10.3389/fmicb.2019.01994
ZhangPWangJWangXBaiXMaJDangRXiongYFanningSBaiLYangZ.Characterization of five Escherichia coli isolates coexpressing ESBL and mcr-1 resistance mechanisms from different origins in China.Front Microbiol.2019Aug;10:1994.https://doi.org/10.3389/fmicb.2019.01994
Zhou Y, Ai W, Cao Y, Guo Y, Wu X, Wang B, Rao L, Xu Y, Zhao H, Wang X et al. The co-occurrence of NDM-5, mcr-1, and fosa3-encoding plasmids contributed to the generation of extensively drug-resistant Klebsiella pneumoniae. Front Microbiol. 2022 Jan; 12:811263. https://doi.org/10.3389/fmicb.2021.811263
ZhouYAiWCaoYGuoYWuXWangBRaoLXuYZhaoHWangXThe co-occurrence of NDM-5, mcr-1, and fosa3-encoding plasmids contributed to the generation of extensively drug-resistant Klebsiella pneumoniae.Front Microbiol.2022Jan;12:811263.https://doi.org/10.3389/fmicb.2021.811263