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A Mendelian Randomization Study: Roles of Gut Microbiota in Sepsis – Who is the Angle?

Yeping Bian
Yeping Bian
, 
Jian Xu
Jian Xu
, 
Xiaojing Deng
Xiaojing Deng
 y 
Suming Zhou
Suming Zhou
   | 04 mar 2024
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Article Category: ORIGINAL PAPER
Publicado en línea: 04 mar 2024
Páginas: 49 - 57
Recibido: 30 nov 2023
Aceptado: 04 ene 2024
DOI: https://doi.org/10.33073/pjm-2024-006
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© 2024 Yeping Bian et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

The whole workflow of Mendelian randomization (MR) analysis.
The whole workflow of Mendelian randomization (MR) analysis.

Fig. 2.

Forest plot of estimated effect sizes at genome-wide significance level (p < 5.0 × 10−8) each exposure on outcomes. CI – Confidence interval, F – F statistics, MR – Mendelian randomization, MR method – the type of model applied in MR analysis, Nsnp – number of SNPs, OR – odds ratio, P – p-value of causal estimation in different MR methods, Ple_pval – pleiotropy, Q_pval _ heterogeneity, R2 _ phenotype variance explained by IVs
Forest plot of estimated effect sizes at genome-wide significance level (p < 5.0 × 10−8) each exposure on outcomes. CI – Confidence interval, F – F statistics, MR – Mendelian randomization, MR method – the type of model applied in MR analysis, Nsnp – number of SNPs, OR – odds ratio, P – p-value of causal estimation in different MR methods, Ple_pval – pleiotropy, Q_pval _ heterogeneity, R2 _ phenotype variance explained by IVs

Mendelian randomization (MR) analysis of gut microbiota on sepsis at genome-wide significance level (p < 5.0 × 10−8).

Classification Bacterial taxa Outcome No. SNP MR method Beta SE OR 95% CI P F Horizontal pleiotropy Heterogeneity
Actinobacteria phylum ieu-b-4980 4 IVW −0.222 0.1 0.801 0.658–0.975 0.027 190.05 0.47 0.76
4 Weighted median −0.245 0.116 0.783 0.623–0.983 0.035
ieu-b-5088 4 IVW −0.23 0.099 0.795 0.655–0.964 0.02 190.04 0.6 0.94
4 Weighted median −0.25 0.109 0.779 0.629–0.965 0.022
ieu-b-69 4 IVW −0.338 0.101 0.713 0.585–0.869 0.001 190.04 0.55 0.74
4 Weighted median −0.367 0.118 0.693 0.550–0.873 0.002
ieu-b-69 6 IVW −0.231 0.071 0.794 0.691–0.912 0.001 352.59 0.44 0.02
6 Weighted median −0.241 0.089 0.786 0.660–0.936 0.007
Bifidobacteriaceae order ieu-b-4981 7 IVW 1.051 0.368 2.861 1.391–5.885 0.004 390.71 0.18 0.3
7 Weighted median 1.024 0.49 2.783 1.065–7.276 0.037
ieu-b-69 7 IVW −0.199 0.065 0.819 0.722–0.930 0.002 388.52 0.55 0.74
7 Weighted median −0.208 0.081 0.812 0.692–0.952 0.01
ieu-b-69 7 IVW −0.231 0.071 0.819 0.722–0.930 0.001 388.52 0.55 0.74
7 Weighted median −0.208 0.082 0.812 0.691–0.954 0.012
ieu-b-69 9 IVW −0.204 0.065 0.815 0.724–0.912 0.002 441.31 0.83 0.9
9 Weighted median −0.226 0.079 0.798 0.683–0.931 0.004
Tyzzerella genus finn-b-ASTHMA_PNEUMONIA_AND_SEPSIS 1 Wald ratio −0.371 0.174 0.69 0.490–0.970 0.033 – – –
Gastranaerophilales order finn-b-015_PUERP_SEPSIS 1 Wald ratio −0.526 0.265 0.59 0.352–0.992 0.047 – – –

Details of data sources.

Trait Population Sample_size Case Control
ieu-b-5088 Sepsis (under 75) European 462,869 11,568 451,301
ieu-b-4980 Sepsis European 486,484 11,643 474,841
ieu-b-69 Sepsis European 462,918 10,154 454,764
finn-b-O15_PUERP_SEPSIS Puerperal sepsis European 121,441 2,286 119,155
finn-b-ASTHMA_PNEUMONIA_AND_SEPSIS Asthma-related pneumonia or sepsis European 140,994 5,545 135,449
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