The Effects of Antibiotics on the Development and Treatment of Non-Small Cell Lung Cancer

Alkan G, Senturk Oztas N, Turna ZH, Ozguroglu M. 1168P Effect of antibiotic treatment on immune checkpoint inhibitor efficacy in patients with advanced non-small cell lung cancer. Ann Oncol. 2022; 33:S1082. https://doi.org/10.1016/j.annonc.2022.07.1291 Alkan G Senturk Oztas N Turna ZH Ozguroglu M. 1168P Effect of antibiotic treatment on immune checkpoint inhibitor efficacy in patients with advanced non-small cell lung cancer . Ann Oncol . 2022 ; 33 :S1082. https://doi.org/ 10.1016/j.annonc.2022.07.1291 Open DOISearch in Google Scholar

American Cancer Society. What causes lung cancer? [Internet]. Atlanta (USA): American Cancer Society, Inc.; 2019 [cited 2023 May 5]. Available from https://www.cancer.org/cancer/lung-cancer/causes-risks-prevention/what-causes.html American Cancer Society . What causes lung cancer? [Internet] . Atlanta (USA) : American Cancer Society, Inc .; 2019 [ cited 2023 May 5 ]. Available from https://www.cancer.org/cancer/lung-cancer/causes-risks-prevention/what-causes.html Search in Google Scholar

Brawley OW, Glynn TJ, Khuri FR, Wender RC, Seffrin JR. The first Surgeon General’s report on smoking and health: the 50th anniversary. CA Cancer J Clin. 2014 Jan–Feb;64(1):5–8. https://doi.org/10.3322/caac.21210 Brawley OW Glynn TJ Khuri FR Wender RC Seffrin JR. The first Surgeon General’s report on smoking and health: the 50th anniversary . CA Cancer J Clin . 2014 Jan–Feb ; 64 ( 1 ): 5 – 8 . https://doi.org/ 10.3322/caac.21210 Open DOISearch in Google Scholar

Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 2017 Dec;358(6369):1443–1448. https://doi.org/10.1126/science.aal5240 Bullman S Pedamallu CS Sicinska E Clancy TE Zhang X Cai D Neuberg D Huang K Guevara F Nelson T . Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer . Science . 2017 Dec ; 358 ( 6369 ): 1443 – 1448 . https://doi.org/ 10.1126/science.aal5240 Open DOISearch in Google Scholar

CDC. What are the risk factors for lung cancer? [Internet]. Atlanta (USA): Centers for Disease Control and Prevention; 2023 [cited 2023 May 5]. Available from https://www.cdc.gov/cancer/lung/basic_info/risk_factors.htm CDC . What are the risk factors for lung cancer? [Internet] . Atlanta (USA) : Centers for Disease Control and Prevention ; 2023 [ cited 2023 May 5 ]. Available from https://www.cdc.gov/cancer/lung/basic_info/risk_factors.htm Search in Google Scholar

Chalabi M, Cardona A, Nagarkar DR, Dhawahir Scala A, Gandara DR, Rittmeyer A, Albert ML, Powles T, Kok M, Herrera FG; im CORE working group of early career investigators. Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc analyses of the OAK and POPLAR trials. Ann Oncol. 2020 Apr;31(4):525–531. https://doi.org/10.1016/j.annonc.2020.01.006 Chalabi M Cardona A Nagarkar DR Dhawahir Scala A Gandara DR Rittmeyer A Albert ML Powles T Kok M Herrera FG im CORE working group of early career investigators . Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc analyses of the OAK and POPLAR trials . Ann Oncol . 2020 Apr ; 31 ( 4 ): 525 – 531 . https://doi.org/ 10.1016/j.annonc.2020.01.006 Open DOISearch in Google Scholar

Chang ET, Smedby KE, Hjalgrim H, Schöllkopf C, Porwit-Mac-Donald A, Sundström C, Tani E, d’Amore F, Melbye M, Adami HO, et al. Medication use and risk of non-Hodgkin’s lymphoma. Am J Epidemiol. 2005 Nov;162(10):965–974. https://doi.org/10.1093/aje/kwi311 Chang ET Smedby KE Hjalgrim H Schöllkopf C Porwit-Mac-Donald A Sundström C Tani E d’Amore F Melbye M Adami HO . Medication use and risk of non-Hodgkin’s lymphoma . Am J Epidemiol . 2005 Nov ; 162 ( 10 ): 965 – 974 . https://doi.org/ 10.1093/aje/kwi311 Open DOISearch in Google Scholar

Derosa L, Hellmann MD, Spaziano M, Halpenny D, Fidelle M, Rizvi H, Long N, Plodkowski AJ, Arbour KC, Chaft JE, et al. Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and nonsmall-cell lung cancer. Ann Oncol. 2018 Jun;29(6):1437–1444. https://doi.org/10.1093/annonc/mdy103 Derosa L Hellmann MD Spaziano M Halpenny D Fidelle M Rizvi H Long N Plodkowski AJ Arbour KC Chaft JE . Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and nonsmall-cell lung cancer . Ann Oncol . 2018 Jun ; 29 ( 6 ): 1437 – 1444 . https://doi.org/ 10.1093/annonc/mdy103 Open DOISearch in Google Scholar

Dickson RP, Huffnagle GB. The lung microbiome: New principles for respiratory bacteriology in health and disease. PLoS Pathog. 2015 Jul;11(7):e1004923. https://doi.org/10.1371/journal.ppat.1004923 Dickson RP Huffnagle GB. The lung microbiome: New principles for respiratory bacteriology in health and disease . PLoS Pathog . 2015 Jul ; 11 ( 7 ) :e1004923. https://doi.org/ 10.1371/journal.ppat.1004923 Open DOISearch in Google Scholar

Didham RC, Reith DM, McConnell DW, Harrison KS. Antibiotic exposure and breast cancer in New Zealand. Breast Cancer Res Treat. 2005 Jul;92(2):163–167. https://doi.org/10.1007/s10549-005-2115-8 Didham RC Reith DM McConnell DW Harrison KS. Antibiotic exposure and breast cancer in New Zealand . Breast Cancer Res Treat . 2005 Jul ; 92 ( 2 ): 163 – 167 . https://doi.org/ 10.1007/s10549-005-2115-8 Open DOISearch in Google Scholar

ECIS. European Cancer Information System. Brussels (Belgium): European Union; 2023 [cited 2023 May 5]. Available from https://ecis.jrc.ec.europa.eu ECIS . European Cancer Information System . Brussels (Belgium) : European Union ; 2023 [ cited 2023 May 5 ]. Available from https://ecis.jrc.ec.europa.eu Search in Google Scholar

Elkrief A, Derosa L, Kroemer G, Zitvogel L, Routy B. The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: A new independent prognostic factor? Ann Oncol. 2019 Oct;30(10):1572–1579. https://doi.org/10.1093/annonc/mdz206 Elkrief A Derosa L Kroemer G Zitvogel L Routy B. The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: A new independent prognostic factor? Ann Oncol . 2019 Oct ; 30 ( 10 ): 1572 – 1579 . https://doi.org/ 10.1093/annonc/mdz206 Open DOISearch in Google Scholar

Fang YH, Yang YH, Hsieh MJ, Hung MS, Lin YC. Concurrent proton-pump inhibitors increase risk of death for lung cancer patients receiving 1st-line gefitinib treatment – a nationwide populationbased study. Cancer Manag Res. 2019 Sep;11:8539–8546. https://doi.org/10.2147/CMAR.S222278 Fang YH Yang YH Hsieh MJ Hung MS Lin YC. Concurrent proton-pump inhibitors increase risk of death for lung cancer patients receiving 1st-line gefitinib treatment – a nationwide populationbased study . Cancer Manag Res . 2019 Sep ; 11 : 8539 – 8546 . https://doi.org/ 10.2147/CMAR.S222278 Open DOISearch in Google Scholar

Galli G, Poggi M, Fucà G, Imbimbo M, Proto C, Signorelli D, Vitali M, Zilembo N, Ganzinelli M, de Braud F, et al. Effects of antibiotic use during immunotherapy in metastatic non-small cell lung cancer. Ann Oncol. 2018 Nov;29:viii531. https://doi.org/10.1093/annonc/mdy292.088 Galli G Poggi M Fucà G Imbimbo M Proto C Signorelli D Vitali M Zilembo N Ganzinelli M de Braud F . Effects of antibiotic use during immunotherapy in metastatic non-small cell lung cancer . Ann Oncol . 2018 Nov ; 29 :viii531. https://doi.org/ 10.1093/annonc/mdy292.088 Open DOISearch in Google Scholar

Geum MJ, Kim C, Kang JE, Choi JH, Kim JS, Son ES, Lim SM, Rhie SJ. Broad-spectrum antibiotic regimen affects survival in patients receiving nivolumab for non-small cell lung cancer. Pharmaceuticals. 2021 May;14(5):445. https://doi.org/10.3390/ph14050445 Geum MJ Kim C Kang JE Choi JH Kim JS Son ES Lim SM Rhie SJ. Broad-spectrum antibiotic regimen affects survival in patients receiving nivolumab for non-small cell lung cancer . Pharmaceuticals . 2021 May ; 14 ( 5 ): 445 . https://doi.org/ 10.3390/ph14050445 Open DOISearch in Google Scholar

Gonugunta AS, Von Itzstein MS, Hsiehchen D, Le T, Rashdan S, Yang H, Selby C, Alvarez C, Gerber DE. Antibiotic prescriptions in lung cancer and melanoma populations: Differences with potential clinical implications in the immunotherapy era. Clin Lung Cancer. 2023 Jan;24(1):11–17. https://doi.org/10.1016/j.cllc.2022.09.005 Gonugunta AS Von Itzstein MS Hsiehchen D Le T Rashdan S Yang H Selby C Alvarez C Gerber DE. Antibiotic prescriptions in lung cancer and melanoma populations: Differences with potential clinical implications in the immunotherapy era . Clin Lung Cancer . 2023 Jan ; 24 ( 1 ): 11 – 17 . https://doi.org/ 10.1016/j.cllc.2022.09.005 Open DOISearch in Google Scholar

Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA. The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell. 2018 Apr;33(4):570–580. https://doi.org/10.1016/j.ccell.2018.03.015 Gopalakrishnan V Helmink BA Spencer CN Reuben A Wargo JA. The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy . Cancer Cell . 2018 Apr ; 33 ( 4 ): 570 – 580 . https://doi.org/ 10.1016/j.ccell.2018.03.015 Open DOISearch in Google Scholar

Jernberg C, Löfmark S, Edlund C, Jansson JK. Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. ISME J. 2007 May;1(1):56–66. https://doi.org/10.1038/ismej.2007.3 Jernberg C Löfmark S Edlund C Jansson JK. Long-term ecological impacts of antibiotic administration on the human intestinal microbiota . ISME J . 2007 May ; 1 ( 1 ): 56 – 66 . https://doi.org/ 10.1038/ismej.2007.3 Open DOISearch in Google Scholar

Kilkkinen A, Rissanen H, Klaukka T, Pukkala E, Heliövaara M, Huovinen P, Männistö S, Aromaa A, Knekt P. Antibiotic use predicts an increased risk of cancer. Int J Cancer. 2008 Nov;123(9): 2152–2155. https://doi.org/10.1002/ijc.23622 Kilkkinen A Rissanen H Klaukka T Pukkala E Heliövaara M Huovinen P Männistö S Aromaa A Knekt P. Antibiotic use predicts an increased risk of cancer . Int J Cancer . 2008 Nov ; 123 ( 9 ): 2152 – 2155 . https://doi.org/ 10.1002/ijc.23622 Open DOISearch in Google Scholar

Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB, Howell A, Martinez--Outschoorn UE, Sotgia F, Lisanti MP. Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease. Oncotarget. 2015 Mar;6(7):4569–4584. https://doi.org/10.18632/oncotarget.3174 Lamb R Ozsvari B Lisanti CL Tanowitz HB Howell A Martinez--Outschoorn UE Sotgia F Lisanti MP. Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease . Oncotarget . 2015 Mar ; 6 ( 7 ): 4569 – 4584 . https://doi.org/ 10.18632/oncotarget.3174 Open DOISearch in Google Scholar

Le Noci V, Guglielmetti S, Arioli S, Camisaschi C, Bianchi F, Sommariva M, Storti C, Triulzi T, Castelli C, Balsari A, et al. Modulation of pulmonary microbiota by antibiotic or probiotic aerosol therapy: A strategy to promote immunosurveillance against lung metastases. Cell Rep. 2018 Sep;24(13):3528–3538. https://doi.org/10.1016/j.celrep.2018.08.090 Le Noci V Guglielmetti S Arioli S Camisaschi C Bianchi F Sommariva M Storti C Triulzi T Castelli C Balsari A . Modulation of pulmonary microbiota by antibiotic or probiotic aerosol therapy: A strategy to promote immunosurveillance against lung metastases . Cell Rep . 2018 Sep ; 24 ( 13 ): 3528 – 3538 . https://doi.org/ 10.1016/j.celrep.2018.08.090 Open DOISearch in Google Scholar

Lee SH, Sung JY, Yong D, Chun J, Kim SY, Song JH, Chung KS, Kim EY, Jung JY, Kang YA, et al. Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions. Lung Cancer. 2016 Dec;102:89–95. https://doi.org/10.1016/j.lungcan.2016.10.016 Lee SH Sung JY Yong D Chun J Kim SY Song JH Chung KS Kim EY Jung JY Kang YA . Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions . Lung Cancer . 2016 Dec ; 102 : 89 – 95 . https://doi.org/ 10.1016/j.lungcan.2016.10.016 Open DOISearch in Google Scholar

Liu HX, Tao LL, Zhang J, Zhu YG, Zheng Y, Liu D, Zhou M, Ke H, Shi MM, Qu JM. Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects. Int J Cancer. 2018 Feb; 142(4):769–778. https://doi.org/10.1002/ijc.31098 Liu HX Tao LL Zhang J Zhu YG Zheng Y Liu D Zhou M Ke H Shi MM Qu JM. Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects . Int J Cancer . 2018 Feb ; 142 ( 4 ): 769 – 778 . https://doi.org/ 10.1002/ijc.31098 Open DOISearch in Google Scholar

Löfling L, Bahmanyar S, Kieler H, Lambe M, Wagenius G. Anti-biotic use prior to a lung cancer diagnosis: A population-based study. Cancer Causes Control. 2021 Jun;32(6):597–607. https://doi.org/10.1007/s10552-021-01413-5 Löfling L Bahmanyar S Kieler H Lambe M Wagenius G. Anti-biotic use prior to a lung cancer diagnosis: A population-based study . Cancer Causes Control . 2021 Jun ; 32 ( 6 ): 597 – 607 . https://doi.org/ 10.1007/s10552-021-01413-5 Open DOISearch in Google Scholar

Löfmark S, Jernberg C, Jansson JK, Edlund C. Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes. J Antimicrob Chemother. 2006 Dec; 58(6): 1160–1167. https://doi.org/10.1093/jac/dkl420 Löfmark S Jernberg C Jansson JK Edlund C. Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes . J Antimicrob Chemother . 2006 Dec ; 58 ( 6 ): 1160 – 1167 . https://doi.org/ 10.1093/jac/dkl420 Open DOISearch in Google Scholar

Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012 Sep;489(7415):220–230. https://doi.org/10.1038/nature11550 Lozupone CA Stombaugh JI Gordon JI Jansson JK Knight R. Diversity, stability and resilience of the human gut microbiota . Nature . 2012 Sep ; 489 ( 7415 ): 220 – 230 . https://doi.org/ 10.1038/nature11550 Open DOISearch in Google Scholar

Lurienne L, Cervesi J, Duhalde L, de Gunzburg J, Andremont A, Zalcman G, Buffet R, Bandinelli PA. NSCLC immunotherapy efficacy and antibiotic use: A systematic review and meta-analysis. J Thorac Oncol. 2020 Jul;15(7):1147–1159. https://doi.org/10.1016/j.jtho.2020.03.002 Lurienne L Cervesi J Duhalde L de Gunzburg J Andremont A Zalcman G Buffet R Bandinelli PA. NSCLC immunotherapy efficacy and antibiotic use: A systematic review and meta-analysis . J Thorac Oncol . 2020 Jul ; 15 ( 7 ): 1147 – 1159 . https://doi.org/ 10.1016/j.jtho.2020.03.002 Open DOISearch in Google Scholar

Majeed U, Zhou K, Heng F, Seegobin K, Zhao Y, Manochakian R, Lou Y. P13.01 Use of antibiotics is associated with an increase in immunotherapy related adverse effects in patients with non-small cell lung cancer. J Thorac Oncol. 2021 Oct;16(10):S1010. https://doi.org/10.1016/j.jtho.2021.08.330 Majeed U Zhou K Heng F Seegobin K Zhao Y Manochakian R Lou Y. P13.01 Use of antibiotics is associated with an increase in immunotherapy related adverse effects in patients with non-small cell lung cancer . J Thorac Oncol . 2021 Oct ; 16 ( 10 ) :S1010. https://doi.org/ 10.1016/j.jtho.2021.08.330 Open DOISearch in Google Scholar

Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre ML, Luke JJ, Gajewski TF. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science. 2018 Jan; 359(6371):104–108. https://doi.org/10.1126/science.aao3290 Matson V Fessler J Bao R Chongsuwat T Zha Y Alegre ML Luke JJ Gajewski TF. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients . Science . 2018 Jan ; 359 ( 6371 ): 104 – 108 . https://doi.org/ 10.1126/science.aao3290 Open DOISearch in Google Scholar

Mayo Clinic. Antibiotics: Are you misusing them? [Internet]. Rochester (USA): Mayo Foundation for Medical Education and Research; 2023 [cited 2023 May 5]. Available from https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/antibiotics/art-20045720 Mayo Clinic . Antibiotics: Are you misusing them? [Internet] . Rochester (USA) : Mayo Foundation for Medical Education and Research ; 2023 [ cited 2023 May 5 ]. Available from https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/antibiotics/art-20045720 Search in Google Scholar

Nyein AF, Bari S, Hogue S, Zhao Y, Maller B, Sha S, Gomez MF, Rollison DE, Robinson LA. Effect of prior antibiotic or chemotherapy treatment on immunotherapy response in non-small cell lung cancer. BMC Cancer. 2022 Jan ;22(1):101. https://doi.org/10.1186/s12885-022-09210-2 Nyein AF Bari S Hogue S Zhao Y Maller B Sha S Gomez MF Rollison DE Robinson LA. Effect of prior antibiotic or chemotherapy treatment on immunotherapy response in non-small cell lung cancer . BMC Cancer . 2022 Jan ; 22 ( 1 ): 101 . https://doi.org/ 10.1186/s12885-022-09210-2 Open DOISearch in Google Scholar

Ochi N, Ichihara E, Takigawa N, Harada D, Inoue K, Shibayama T, Hosokawa S, Kishino D, Harita S, Oda N, et al. The effects of antibiotics on the efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer differ based on PD-L1 expression. Eur J Cancer. 2021 May;149:73–81. https://doi.org/10.1016/j.ejca.2021.02.040 Ochi N Ichihara E Takigawa N Harada D Inoue K Shibayama T Hosokawa S Kishino D Harita S Oda N . The effects of antibiotics on the efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer differ based on PD-L1 expression . Eur J Cancer . 2021 May ; 149 : 73 – 81 . https://doi.org/ 10.1016/j.ejca.2021.02.040 Open DOISearch in Google Scholar

Palleja A, Mikkelsen KH, Forslund SK, Kashani A, Allin KH, Nielsen T, Hansen TH, Liang S, Feng Q, Zhang C, et al Recovery of gut microbiota of healthy adults following antibiotic exposure. Nat Microbiol. 2018 Nov;3(11):1255–1265. https://doi.org/10.1038/s41564-018-0257-9 Palleja A Mikkelsen KH Forslund SK Kashani A Allin KH Nielsen T Hansen TH Liang S Feng Q Zhang C Recovery of gut microbiota of healthy adults following antibiotic exposure . Nat Microbiol . 2018 Nov ; 3 ( 11 ): 1255 – 1265 . https://doi.org/ 10.1038/s41564-018-0257-9 Open DOISearch in Google Scholar

Petrelli F, Ghidini M, Ghidini A, Perego G, Cabiddu M, Khakoo S, Oggionni E, Abeni C, Hahne JC, Tomasello G, et al. Use of antibiotics and risk of cancer: A systematic review and meta-analysis of observational studies. Cancers. 2019 Aug;11(8):1174. https://doi.org/10.3390/cancers11081174 Petrelli F Ghidini M Ghidini A Perego G Cabiddu M Khakoo S Oggionni E Abeni C Hahne JC Tomasello G . Use of antibiotics and risk of cancer: A systematic review and meta-analysis of observational studies . Cancers . 2019 Aug ; 11 ( 8 ): 1174 . https://doi.org/ 10.3390/cancers11081174 Open DOISearch in Google Scholar

Pierrard J, Seront E. Impact of the gut microbiome on immune checkpoint inhibitor efficacy – a systematic review. Curr Oncol. 2019 Dec;26(6):395–403. https://doi.org/10.3747/co.26.5177 Pierrard J Seront E. Impact of the gut microbiome on immune checkpoint inhibitor efficacy – a systematic review . Curr Oncol . 2019 Dec ; 26 ( 6 ): 395 – 403 . https://doi.org/ 10.3747/co.26.5177 Open DOISearch in Google Scholar

Ramírez-Labrada AG, Isla D, Artal A, Arias M, Rezusta A, Pardo J, Gálvez EM. The influence of lung microbiota on lung carcinogenesis, immunity, and immunotherapy. Trends Cancer. 2020 Feb;6(2): 86–97. https://doi.org/10.1016/j.trecan.2019.12.007 Ramírez-Labrada AG Isla D Artal A Arias M Rezusta A Pardo J Gálvez EM. The influence of lung microbiota on lung carcinogenesis, immunity, and immunotherapy . Trends Cancer . 2020 Feb ; 6 ( 2 ): 86 – 97 . https://doi.org/ 10.1016/j.trecan.2019.12.007 Open DOISearch in Google Scholar

Ritter JM, Flower R, Henderson G, Loke YK, MacEwan D, Rang HP. Rang and Dale’s pharmacology, 9th ed. Edinburgh (UK): Elsevier. p. 673. Ritter JM Flower R Henderson G Loke YK MacEwan D Rang HP. Rang and Dale’s pharmacology , 9^th ed . Edinburgh (UK) : Elsevier . p. 673 . Search in Google Scholar

Rizzo A, Cusmai A, Giovannelli F, Acquafredda S, Rinaldi L, Misino A, Montagna ES, Ungaro V, Lorusso M, Palmiotti G. Impact of proton pump inhibitors and histamine-2-receptor antagonists on non-small cell lung cancer immunotherapy: A systematic review and meta-analysis. Cancers. 2022 Mar;14(6):1404. https://doi.org/10.3390/cancers14061404 Rizzo A Cusmai A Giovannelli F Acquafredda S Rinaldi L Misino A Montagna ES Ungaro V Lorusso M Palmiotti G. Impact of proton pump inhibitors and histamine-2-receptor antagonists on non-small cell lung cancer immunotherapy: A systematic review and meta-analysis . Cancers . 2022 Mar ; 14 ( 6 ): 1404 . https://doi.org/ 10.3390/cancers14061404 Open DOISearch in Google Scholar

Routy B, Gopalakrishnan V, Daillère R, Zitvogel L, Wargo JA, Kroemer G. The gut microbiota influences anticancer immunosurveillance and general health. Nat Rev Clin Oncol. 2018b Jun;15(6): 382–396. https://doi.org/10.1038/S41571-018-0006-2 Routy B Gopalakrishnan V Daillère R Zitvogel L Wargo JA Kroemer G. The gut microbiota influences anticancer immunosurveillance and general health . Nat Rev Clin Oncol . 2018b Jun ; 15 ( 6 ): 382 – 396 . https://doi.org/ 10.1038/S41571-018-0006-2 Open DOISearch in Google Scholar

Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018a Jan;359(6371):91–97. https://doi.org/10.1126/science.aan3706 Routy B Le Chatelier E Derosa L Duong CPM Alou MT Daillère R Fluckiger A Messaoudene M Rauber C Roberti MP . Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors . Science . 2018a Jan ; 359 ( 6371 ): 91 – 97 . https://doi.org/ 10.1126/science.aan3706 Open DOISearch in Google Scholar

Ruiz-Patiño A, Barrón F, Cardona AF, Corrales L, Mas L, Martín C, Zatarain-Barrón ZL, Recondo G, Ricaurte L, Rojas L, et al.; CLICaP. Antibiotics impair immune checkpoint inhibitor effectiveness in Hispanic patients with non-small cell lung cancer (AB-CLICaP). Thorac Cancer. 2020 Sep;11(9):2552–2560. https://doi.org/10.1111/1759-7714.13573 Ruiz-Patiño A Barrón F Cardona AF Corrales L Mas L Martín C Zatarain-Barrón ZL Recondo G Ricaurte L Rojas L .; CLICaP. Antibiotics impair immune checkpoint inhibitor effectiveness in Hispanic patients with non-small cell lung cancer (AB-CLICaP) . Thorac Cancer . 2020 Sep ; 11 ( 9 ): 2552 – 2560 . https://doi.org/ 10.1111/1759-7714.13573 Open DOISearch in Google Scholar

Santacroce L, Charitos IA, Ballini A, Inchingolo F, Luperto P, De Nitto E, Topi S. The Human respiratory system and its microbiome at a glimpse. Biology. 2020 Oct;9(10):318. https://doi.org/10.3390/biology9100318 Santacroce L Charitos IA Ballini A Inchingolo F Luperto P De Nitto E Topi S. The Human respiratory system and its microbiome at a glimpse . Biology . 2020 Oct ; 9 ( 10 ): 318 . https://doi.org/ 10.3390/biology9100318 Open DOISearch in Google Scholar

Schabath MB, Cote ML. Cancer progress and priorities: Lung cancer. Cancer Epidemiol Biomarkers Prev. 2019 Oct;28(10):1563–1579. https://doi.org/10.1158/1055-9965.EPI-19-0221 Schabath MB Cote ML. Cancer progress and priorities: Lung cancer . Cancer Epidemiol Biomarkers Prev . 2019 Oct ; 28 ( 10 ): 1563 – 1579 . https://doi.org/ 10.1158/1055-9965.EPI-19-0221 Open DOISearch in Google Scholar

Schett A, Rothschild SI, Curioni-Fontecedro A, Krähenbühl S, Früh M, Schmid S, Driessen C, Joerger M. Predictive impact of antibiotics in patients with advanced non small-cell lung cancer receiving immune checkpoint inhibitors: Antibiotics immune checkpoint inhibitors in advanced NSCLC. Cancer Chemother Pharmacol. 2020 Jan;85(1):121–131. https://doi.org/10.1007/s00280-019-03993-1 Schett A Rothschild SI Curioni-Fontecedro A Krähenbühl S Früh M Schmid S Driessen C Joerger M. Predictive impact of antibiotics in patients with advanced non small-cell lung cancer receiving immune checkpoint inhibitors: Antibiotics immune checkpoint inhibitors in advanced NSCLC . Cancer Chemother Pharmacol . 2020 Jan ; 85 ( 1 ): 121 – 131 . https://doi.org/ 10.1007/s00280-019-03993-1 Open DOISearch in Google Scholar

Seki H, Shiohara M, Matsumura T, Miyagawa N, Tanaka M, Komiyama A, Kurata S. Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI. Pediatr Int. 2003 Feb; 45(1): 86–90. https://doi.org/10.1046/j.1442-200X.2003.01671.x Seki H Shiohara M Matsumura T Miyagawa N Tanaka M Komiyama A Kurata S. Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI . Pediatr Int . 2003 Feb ; 45 ( 1 ): 86 – 90 . https://doi.org/ 10.1046/j.1442-200X.2003.01671.x Open DOISearch in Google Scholar

Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015 Nov;350(6264):1084–1089. https://doi.org/10.1126/science.aac4255 Sivan A Corrales L Hubert N Williams JB Aquino-Michaels K Earley ZM Benyamin FW Lei YM Jabri B Alegre ML . Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy . Science . 2015 Nov ; 350 ( 6264 ): 1084 – 1089 . https://doi.org/ 10.1126/science.aac4255 Open DOISearch in Google Scholar

Sullivan A, Edlund C, Nord CE. Effect of antimicrobial agents on the ecological balance of human microflora. Lancet Infect Dis. 2001 Sep; 1(2):101–114. https://doi.org/10.1016/S1473-3099(01)00066-4 Sullivan A Edlund C Nord CE. Effect of antimicrobial agents on the ecological balance of human microflora . Lancet Infect Dis . 2001 Sep ; 1 ( 2 ): 101 – 114 . https://doi.org/ 10.1016/S1473-3099(01)00066-4 Open DOISearch in Google Scholar

Thomas S. Antimicrobial resistance: Global challenges and future interventions. Singapore: Springer Singapore; 2020. https://doi.org/10.1007/978-981-15-3658-8 Thomas S. Antimicrobial resistance: Global challenges and future interventions . Singapore : Springer Singapore ; 2020 . https://doi.org/ 10.1007/978-981-15-3658-8 Open DOISearch in Google Scholar

Tomita Y, Ikeda T, Sakata S, Saruwatari K, Sato R, Iyama S, Jodai T, Akaike K, Ishizuka S, Saeki S, et al. Association of probiotic Clostridium butyricum therapy with survival and response to immune checkpoint blockade in patients with lung cancer. Cancer Immunol Res. 2020 Oct;8(10):1236–1242. https://doi.org/10.1158/2326-6066.CIR-20-0051 Tomita Y Ikeda T Sakata S Saruwatari K Sato R Iyama S Jodai T Akaike K Ishizuka S Saeki S . Association of probiotic Clostridium butyricum therapy with survival and response to immune checkpoint blockade in patients with lung cancer . Cancer Immunol Res . 2020 Oct ; 8 ( 10 ): 1236 – 1242 . https://doi.org/ 10.1158/2326-6066.CIR-20-0051 Open DOISearch in Google Scholar

Velicer CM, Heckbert SR, Lampe JW, Potter JD, Robertson CA, Taplin SH. Antibiotic use in relation to the risk of breast cancer. JAMA. 2004 Feb;291(7):827–835. https://doi.org/10.1001/jama.291.7.827 Velicer CM Heckbert SR Lampe JW Potter JD Robertson CA Taplin SH. Antibiotic use in relation to the risk of breast cancer . JAMA . 2004 Feb ; 291 ( 7 ): 827 – 835 . https://doi.org/ 10.1001/jama.291.7.827 Open DOISearch in Google Scholar

Weinberger SE, Cockrill BA, Mandel J. 20 – Lung cancer: Etiologic and pathologic aspects. In: Principles of pulmonary medicine, 7th ed. Philadelphia (USA): Elsevier; 2019. p. 263. https://doi.org/10.1016/B978-0-323-52371-4.00023-4 Weinberger SE Cockrill BA Mandel J. 20 – Lung cancer: Etiologic and pathologic aspects . In: Principles of pulmonary medicine , 7^th ed . Philadelphia (USA) : Elsevier ; 2019 . p. 263 . https://doi.org/ 10.1016/B978-0-323-52371-4.00023-4 Open DOISearch in Google Scholar

WHO. Antibiotic resistance [Internet]. Geneva (Switzerland): World Health Organization; 2023 [cited 2023 April 30]. Available from https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance WHO . Antibiotic resistance [Internet] . Geneva (Switzerland) : World Health Organization ; 2023 [ cited 2023 April 30 ]. Available from https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance Search in Google Scholar

Wu X, Li F, Wang X, Li C, Meng Q, Wang C, Huang J, Chen S, Zhu Z. Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism. Biochem Biophys Res Commun. 2018 Jan;495(1):267–272. https://doi.org/10.1016/j.bbrc.2017.10.136 Wu X Li F Wang X Li C Meng Q Wang C Huang J Chen S Zhu Z. Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism . Biochem Biophys Res Commun . 2018 Jan ; 495 ( 1 ): 267 – 272 . https://doi.org/ 10.1016/j.bbrc.2017.10.136 Open DOISearch in Google Scholar

You WC, Brown LM, Zhang L, Li JY, Jin ML, Chang YS, Ma JL, Pan KF, Liu WD, Hu Y, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst. 2006 Jul;98(14):974–983. https://doi.org/10.1093/jnci/djj264 You WC Brown LM Zhang L Li JY Jin ML Chang YS Ma JL Pan KF Liu WD Hu Y . Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions . J Natl Cancer Inst . 2006 Jul ; 98 ( 14 ): 974 – 983 . https://doi.org/ 10.1093/jnci/djj264 Open DOISearch in Google Scholar

Zhang H, García Rodríguez LA, Hernández-Díaz S. Antibiotic use and the risk of lung cancer. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1308–1315. https://doi.org/10.1158/1055-9965.EPI-07-2817 Zhang H García Rodríguez LA Hernández-Díaz S. Antibiotic use and the risk of lung cancer . Cancer Epidemiol Biomarkers Prev . 2008 Jun ; 17 ( 6 ): 1308 – 1315 . https://doi.org/ 10.1158/1055-9965.EPI-07-2817 Open DOISearch in Google Scholar

Zitvogel L, Ayyoub M, Routy B, Kroemer G. Microbiome and anticancer immunosurveillance. Cell. 2016 Apr;165(2):276–287. https://doi.org/10.1016/j.cell.2016.03.001 Zitvogel L Ayyoub M Routy B Kroemer G. Microbiome and anticancer immunosurveillance . Cell . 2016 Apr ; 165 ( 2 ): 276 – 287 . https://doi.org/ 10.1016/j.cell.2016.03.001 Open DOISearch in Google Scholar