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Microbiota Diversity in Non-Small Cell Lung Cancer Gut and Mouth Cavity Microbiota Diversity in Non-Small Cell Lung Cancer Patients

Aneta Brisudová
Aneta Brisudová
, 
Hana Bielniková-Kryštofová
Hana Bielniková-Kryštofová
, 
Oldřich Motyka
Oldřich Motyka
, 
Dominika Fritzová
Dominika Fritzová
, 
Vladimíra Katuchová
Vladimíra Katuchová
, 
Natálie Ponikelská
Natálie Ponikelská
, 
Daniela Skanderová
Daniela Skanderová
, 
Vladislav Raclavský
Vladislav Raclavský
, 
Jaroslav Michálek
Jaroslav Michálek
, 
Marcel Mitták
Marcel Mitták
, 
Petra Švecová
Petra Švecová
, 
Petr Jakubec
Petr Jakubec
, 
Denisa Rozsivalová
Denisa Rozsivalová
, 
Marek Szkorupa
Marek Szkorupa
, 
JIří Klein
JIří Klein
, 
Jozef Škarda
Jozef Škarda
, 
Zdeněk Kolář
Zdeněk Kolář
 y 
Valeria Skopelidou
Valeria Skopelidou
   | 16 dic 2023
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Article Category: ORIGINAL PAPER
Publicado en línea: 16 dic 2023
Páginas: 467 - 475
Recibido: 10 ago 2023
Aceptado: 27 oct 2023
DOI: https://doi.org/10.33073/pjm-2023-044
Palabras clave
© 2023 Aneta Brisudová et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Relative abundance (%) of bacterial species overrepresented ≥ 1.5 ×, or underrepresented ≤ 0.5 ×, in ADC versus SCC patients’ mouth wash. Y axis – number of patients, blue columns – ADC patients, orange columns – SCC patients, * – significant difference (p ≤ 0.05), ADC – adenocarcinoma, SCC – squamous cell carcinoma
Relative abundance (%) of bacterial species overrepresented ≥ 1.5 ×, or underrepresented ≤ 0.5 ×, in ADC versus SCC patients’ mouth wash. Y axis – number of patients, blue columns – ADC patients, orange columns – SCC patients, * – significant difference (p ≤ 0.05), ADC – adenocarcinoma, SCC – squamous cell carcinoma

Fig. 2.

Relative abundance (%) of bacterial species overrepresented ≥ 1.5 ×, or underrepresented ≤ 0.5 ×, in ADC versus SCC patients’ rectal swabs. Y axis – number of patients, blue columns – ADC patients, orange columns – SCC patients, * – significant difference (p ≤ 0.05), ADC – adenocarcinoma, SCC – squamous cell carcinoma
Relative abundance (%) of bacterial species overrepresented ≥ 1.5 ×, or underrepresented ≤ 0.5 ×, in ADC versus SCC patients’ rectal swabs. Y axis – number of patients, blue columns – ADC patients, orange columns – SCC patients, * – significant difference (p ≤ 0.05), ADC – adenocarcinoma, SCC – squamous cell carcinoma

Fig. 3.

Correlation of smoking status and overall survival probability presented using Kaplan-Meier survival curves. N signifies non-smokers, while Y represents smokers.
Correlation of smoking status and overall survival probability presented using Kaplan-Meier survival curves. N signifies non-smokers, while Y represents smokers.

Characterization of the patient cohort.

ADC SCC
Age median 72 70
Male/Female 54/32 39/16
Stage I 12 13
II 9 10
III 23 17
IV 42 15
Smoker 26 22
Ex-smoker 45 26
Non-smoker 15 7

Comparison of bacterial species cultured from rectal swabs in adenocarcinoma (ADC; n = 85) and squamous cell carcinoma (SCC; n = 52) in NSCLC patients versus patients without confirmed lung cancer (n = 65). The species are ranked according to the measure of overrepresentation in ADC versus SCC patients (column 6, ADC/SCC ratio). Only those overrepresented ≥ 1,5 × or underrepresented ≤ 0,5 × are listed.

Species ADC patients SCC patients No lung cancer ADC/SCC ratio p-value ADC/SCC p-value ADC/non
n % n % n %
Klebsiella oxytoca 11 12,9 1 1,9 8 12,3 6,8 – 0,688
Streptococcus anginosus 42 49,4 12 22,6 33 50,8 2,2 0,002 0,109
Streptococcus MOPP* 20 23,5 6 11,3 12 18,5 2,1 0,074 0,453
Collinsella aerofaciens 28 32,9 10 18,9 13 20,0 1,7 0,072 0,086
Corynebacterium aurimucosum 12 14,1 15 28,3 19 29,2 0,5 0,041 0,024
Alistipes shahii 2 2,4 5 9,6 2 30,8 0,2 – –

Comparison of bacterial species cultured from mouth wash in adenocarcinoma (ADC; n = 85) and squamous cell carcinoma (SCC; n = 53) in NSCLC patients versus patients without confirmed lung cancer (n = 65). The species are ranked according to the measure of overrepresentation in ADC versus SCC patients (column 6, ADC/SCC ratio). Only those overrepresented ≥ 1,5 × or underrepresented ≤ 0,5 × are listed.

Species ADC patients SCC patients No lung cancer ADC/SCC ratio p-value ADC/SCC p-value ADC/non
n % n % n %
Rothia aeria 9 10.5 1 0.2 14 21.5 52.5 – –
Streptococcus constellatus 13 15.1 3 5.5 16 24.6 2.7 0.080 0.152
Neisseria macacae 21 24.4 6 10.9 13 20.0 2.2 0.047 0.495
Streptococcus mutans 24 27.9 7 12.7 9 13.8 2.2 0.034 0.035
Streptococcus sanguinis 25 29.1 8 14.5 16 24.6 2.0 0.047 0.514
Streptococcus anginosus 46 53.5 19 34.5 23 35.4 1.5 0.028 0.023
Lactobacillus fermentum 9 10.5 17 30.9 14 20.9 0.3 0.002 0.065
Candida tropicalis 2 2.4 11 20.8 1 0.01 0.1 – –
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