<abstract xmlns="http://www.w3.org/1999/xhtml"><p><italic>Mycoplasma hominis</italic> is associated with various infections, for which the treatment can be complex. Lipoic acid (LA) plays a role as a cofactor in eukaryotes, most Bacteria, and some Archea. Research of recent years has increasingly pointed to the therapeutic properties of exogenously supplemented LA. The present study was conducted on 40 strains of <italic>M. hominis</italic> cultured with the following LA concentrations: 1,200 μg/ml, 120 μg/ml, and 12 μg/ml. The bacterial colonies of each strain were counted and expressed as the number of colony-forming units/ml (CFU). The number of CFU in <italic>M. hominis</italic> strains obtained in the presence of LA was compared with the number of CFU in the strains grown in the media without LA. The obtained results indicated that the presence of LA in the medium did not affect the growth of <italic>M. hominis</italic>. The investigation of the influence of LA on the growth and survival of microbial cells not only allows for obtaining an answer to the question of whether LA has antimicrobial activity and, therefore, can be used as a drug supporting the treatment of patients infected with a given pathogenic microorganism. Such studies are also crucial for a better understanding of LA metabolism in the microbial cells, which is also important for the search for new antimicrobial drugs. This research is, therefore, an introduction to such further studies.</p></abstract>

Mycoplasma hominis is associated with various infections, for which the treatment can be complex. Lipoic acid (LA) plays a role as a cofactor in eukaryotes, most Bacteria, and some Archea. Research of recent years has increasingly pointed to the therapeutic properties of exogenously supplemented LA. The present study was conducted on 40 strains of M. hominis cultured with the following LA concentrations: 1,200 μg/ml, 120 μg/ml, and 12 μg/ml. The bacterial colonies of each strain were counted and expressed as the number of colony-forming units/ml (CFU). The number of CFU in M. hominis strains obtained in the presence of LA was compared with the number of CFU in the strains grown in the media without LA. The obtained results indicated that the presence of LA in the medium did not affect the growth of M. hominis. The investigation of the influence of LA on the growth and survival of microbial cells not only allows for obtaining an answer to the question of whether LA has antimicrobial activity and, therefore, can be used as a drug supporting the treatment of patients infected with a given pathogenic microorganism. Such studies are also crucial for a better understanding of LA metabolism in the microbial cells, which is also important for the search for new antimicrobial drugs. This research is, therefore, an introduction to such further studies.

Lipoic Acid Does Not Affect The Growth of <italic>Mycoplasma hominis</italic> Cells <italic>In Vitro</italic>

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Lipoic Acid Does Not Affect The Growth of  Cells 

Mycoplasma hominis is associated with various infections, for which the treatment can be complex. Lipoic acid (LA) plays a role as a cofactor in eukaryotes,...

The change in the CFU value	Concentration of lipoic acid (μg/ml)
	1200	120	12
	Number of strains
increased	21	21	21
decreased	18	18	17
unchanged	1	1	2

Lipoic Acid Does Not Affect The Growth of Mycoplasma hominis Cells In Vitro

Article Category: original-paper

Publicado en línea: 20 dic 2021

Páginas: 521 - 526

Recibido: 14 oct 2021

Aceptado: 28 nov 2021

DOI: https://doi.org/10.33073/pjm-2021-050

Palabras clave
lipoic acid, lipoic acid metabolism in microbial cells, lipoyl carrier protein

© 2021 Małgorzata Biernat-Sudolska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Fig. 2.

The effect of lipoic acid on the value of CFU of M. homins strains.

Lipoic Acid Does Not Affect The Growth of Mycoplasma hominis Cells In Vitro

Article Category: original-paper

Publicado en línea: 20 dic 2021

Páginas: 521 - 526

Recibido: 14 oct 2021

Aceptado: 28 nov 2021

DOI: https://doi.org/10.33073/pjm-2021-050

Palabras clavelipoic acid, lipoic acid metabolism in microbial cells, lipoyl carrier protein

© 2021 Małgorzata Biernat-Sudolska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Fig. 2.

The effect of lipoic acid on the value of CFU of M. homins strains.

Palabras clave
lipoic acid, lipoic acid metabolism in microbial cells, lipoyl carrier protein