<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Silent genes are DNA sequences that are generally not expressed or expressed at a very low level. These genes become active as a result of mutation, recombination, or insertion. Silent genes can also be activated in laboratory conditions using pleiotropic, targeted genome-wide, or biosynthetic gene cluster approaches. Like every other gene, silent genes can spread through horizontal gene transfer. Most studies have focused on strains with phenotypic resistance, which is the most common subject. However, to fully understand the mechanism behind the spreading of antibiotic resistance, it is reasonable to study the whole resistome, including silent genes.</p><p><fig id="j_pjm-2021-040_fig_001" position="float" fig-type="figure"><graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_pjm-2021-040_fig_001.jpg"></graphic></fig></p></abstract>

Silent genes are DNA sequences that are generally not expressed or expressed at a very low level. These genes become active as a result of mutation, recombination, or insertion. Silent genes can also be activated in laboratory conditions using pleiotropic, targeted genome-wide, or biosynthetic gene cluster approaches. Like every other gene, silent genes can spread through horizontal gene transfer. Most studies have focused on strains with phenotypic resistance, which is the most common subject. However, to fully understand the mechanism behind the spreading of antibiotic resistance, it is reasonable to study the whole resistome, including silent genes.

Silent Genes: Antimicrobial Resistance and Antibiotic Production

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Silent Genes: Antimicrobial Resistance and Antibiotic Production"}

Silent genes are DNA sequences that are generally not expressed or expressed at a very low level. These genes become active as a result of mutation,...

Silent Genes: Antimicrobial Resistance and Antibiotic Production

Article Category: mini-review

Publicado en línea: 16 oct 2021

Páginas: 421 - 429

Recibido: 26 jul 2021

Aceptado: 15 sept 2021

DOI: https://doi.org/10.33073/pjm-2021-040

Palabras clave
silent genes, antimicrobial resistance, spp., mutations

© 2021 Monika Stasiak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Silent Genes: Antimicrobial Resistance and Antibiotic Production

Article Category: mini-review

Publicado en línea: 16 oct 2021

Páginas: 421 - 429

Recibido: 26 jul 2021

Aceptado: 15 sept 2021

DOI: https://doi.org/10.33073/pjm-2021-040

Palabras clavesilent genes, antimicrobial resistance, spp., mutations

© 2021 Monika Stasiak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
silent genes, antimicrobial resistance, spp., mutations