<abstract xmlns="http://www.w3.org/1999/xhtml"><p> As being the most debated polygenic disease, rheumatoid arthritis elicits great interest in the study of association with genetic factors in various ethnic and racial groups. Some of the HLA-DRB1 alleles are encoding shared epitope amino acids that are not conferring the same risk in various populations. Our study focuses on the evaluation of the distribution of HLA-DRB1 alleles in Romanian patients with early rheumatoid arthritis, along with controls by using PCRSSP method. HLA-DRB1 allele genotyping showed statistically significant differences given by a higher allele frequency for *04, *01 and *14. Also, in our study was observed a lower frequency for *03,*11,*13 and *15 HLA-DRB1 allele in patients group compared with controls, also a high frequency for *0404 and *0408 allele, in contrast with *0401 and *0402 which were significantly lower in patients than in controls. *0403, *0405 and *10 were not associated with early rheumatoid arthritis in our group diagnosed according with new classification criteria ACR/EULAR 2010. In present study we found a negative association of *0402, *11 and *13 with early rheumatoid arthritis. Results of our study are demonstrating the need of a continuous work of allele tracing and associating with rheumatoid arthritis, especially in cases early diagnosed in order to create sufficient premises for instituting a correct and possibly long term remissive treatment.</p></abstract>

As being the most debated polygenic disease, rheumatoid arthritis elicits great interest in the study of association with genetic factors in various ethnic and racial groups. Some of the HLA-DRB1 alleles are encoding shared epitope amino acids that are not conferring the same risk in various populations. Our study focuses on the evaluation of the distribution of HLA-DRB1 alleles in Romanian patients with early rheumatoid arthritis, along with controls by using PCRSSP method. HLA-DRB1 allele genotyping showed statistically significant differences given by a higher allele frequency for *04, *01 and *14. Also, in our study was observed a lower frequency for *03,*11,*13 and *15 HLA-DRB1 allele in patients group compared with controls, also a high frequency for *0404 and *0408 allele, in contrast with *0401 and *0402 which were significantly lower in patients than in controls. *0403, *0405 and *10 were not associated with early rheumatoid arthritis in our group diagnosed according with new classification criteria ACR/EULAR 2010. In present study we found a negative association of *0402, *11 and *13 with early rheumatoid arthritis. Results of our study are demonstrating the need of a continuous work of allele tracing and associating with rheumatoid arthritis, especially in cases early diagnosed in order to create sufficient premises for instituting a correct and possibly long term remissive treatment.

HLA-DRB1 Frequency in Romanian patients with early rheumatoid arthritis

“Ovidius” University of Constanta, Faculty of Medicine, Ist Department – Preclinical disciplines – Discipline of Pathology and Immunology, Romania, University Street, No. 1, Campus B, Constanta, Romania

“Ovidius” University of Constanta, Faculty of Medicine, Ist Department – Preclinical disciplines – Discipline of Genetics, Romania

“Ovidius” University of Constanta, Faculty of Medicine, IInd Department – Medical clinical disciplines – Discipline of Rheumatology, Romania

ARS Medica Tomitana

{"article-title":"HLA-DRB1 Frequency in Romanian patients with early rheumatoid arthritis"}

As being the most debated polygenic disease, rheumatoid arthritis elicits great interest in the study of association with genetic factors in various ethnic and...

HLA-DRB1 Frequency in Romanian patients with early rheumatoid arthritis

Publicado en línea: 26 mar 2013

Páginas: 204 - 208

DOI: https://doi.org/10.2478/v10307-012-0034-6

Palabras clave
early rheumatoid arthritis, HLA-DRB1, allele distribution

This content is open access.

HLA-DRB1 Frequency in Romanian patients with early rheumatoid arthritis

Publicado en línea: 26 mar 2013

Páginas: 204 - 208

DOI: https://doi.org/10.2478/v10307-012-0034-6

Palabras claveearly rheumatoid arthritis, HLA-DRB1, allele distribution

This content is open access.

Palabras clave
early rheumatoid arthritis, HLA-DRB1, allele distribution