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Publicado en línea: 13 nov 2012
Páginas: 115 - 130
DOI: https://doi.org/10.2478/v10127-012-0012-1
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We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.