<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with <italic>Franciselle tularensis</italic> and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected mice exposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected.</p></abstract>

The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with Franciselle tularensis and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected mice exposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected.

Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice

Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic

Centre of Biological Defense, Techonin, Czech Republic

Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic

Interdisciplinary Toxicology

The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor...

Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice

Publicado en línea: 11 may 2012

Páginas: 21 - 24

DOI: https://doi.org/10.2478/v10102-012-0004-7

Palabras clave
intracellular pathogen, immunomodulation, cholinergic system, parasympathicus, cholinergic anti-inflammatory pathway

This content is open access.

Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice

Publicado en línea: 11 may 2012

Páginas: 21 - 24

DOI: https://doi.org/10.2478/v10102-012-0004-7

Palabras claveintracellular pathogen, immunomodulation, cholinergic system, parasympathicus, cholinergic anti-inflammatory pathway

This content is open access.

Palabras clave
intracellular pathogen, immunomodulation, cholinergic system, parasympathicus, cholinergic anti-inflammatory pathway