<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The most important enzymes of detoxication are cytochromes P450 of Phase I and UDPglucuronosyltransferases of Phase II of drug metabolism. The conventional division of drug, or xenobiotic, metabolism to two phases has survived almost fifty years and although not perfect, still is rather informative and practical. The recent addition of the next, third phase to the first two (Phase I as yielding a molecule with free functional groups ready for conjugation with another molecule or its part in Phase II) stressed the importance of drug transport across the membranes even if it is not a pure metabolic process (i.e. a process changing the polarity and structure of a compound).</p></abstract>

The most important enzymes of detoxication are cytochromes P450 of Phase I and UDPglucuronosyltransferases of Phase II of drug metabolism. The conventional division of drug, or xenobiotic, metabolism to two phases has survived almost fifty years and although not perfect, still is rather informative and practical. The recent addition of the next, third phase to the first two (Phase I as yielding a molecule with free functional groups ready for conjugation with another molecule or its part in Phase II) stressed the importance of drug transport across the membranes even if it is not a pure metabolic process (i.e. a process changing the polarity and structure of a compound).

Enzyme systems of detoxication — overview of recent approaches

Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University, CZ-775 15 Olomouc, Czech Republic

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, CZ-775 15 Olomouc, Czech Republic

Interdisciplinary Toxicology

{"article-title":"Enzyme systems of detoxication \u2014 overview of recent approaches"}

The most important enzymes of detoxication are cytochromes P450 of Phase I and UDPglucuronosyltransferases of Phase II of drug metabolism. The conventional...

Enzyme systems of detoxication — overview of recent approaches

Publicado en línea: 01 nov 2010

Páginas: 6 - 7

DOI: https://doi.org/10.2478/v10102-010-0022-2

This content is open access.