<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA. This study presents a preliminary miRNA microarray analysis conducted on pooled ascending aorta RNAs obtained from non familial non syndromic TAA patients (five males and five females) compared to matched control pools. Ninety-nine differentially expressed miRNAs with >1.5-foldup- or down-regulation in TAAs compared to controls were identified, 16.0% of which were similarly regulated in the two sexes. Genes putatively targeted by differentially expressed miRNAs belonged preferentially to focal adhesion and adherens junction pathways. The results indicate an altered regulation of miRNA-mediated gene expression in the cellular interactions of aneurysmal aortic wall.</p></abstract>

The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA. This study presents a preliminary miRNA microarray analysis conducted on pooled ascending aorta RNAs obtained from non familial non syndromic TAA patients (five males and five females) compared to matched control pools. Ninety-nine differentially expressed miRNAs with >1.5-foldup- or down-regulation in TAAs compared to controls were identified, 16.0% of which were similarly regulated in the two sexes. Genes putatively targeted by differentially expressed miRNAs belonged preferentially to focal adhesion and adherens junction pathways. The results indicate an altered regulation of miRNA-mediated gene expression in the cellular interactions of aneurysmal aortic wall.

A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms

Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, 37134,Verona, Italy

Department of Life and Reproduction Sciences, University of Verona, Verona, Italy

Department of Surgery, University of Verona, Verona, Italy

Balkan Journal of Medical Genetics

{"article-title":"A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms"}

The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the...

A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms

Publicado en línea: 22 dic 2012

Páginas: 51 - 55

DOI: https://doi.org/10.2478/v10034-012-0019-6

This content is open access.